loader
Please Wait
Applying Filters...

Evonik Evonik

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about Tenofovir Exalidex, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    Tenofovir Exalidex

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    Temad- We think of world-class quality.

    2D Structure
    1. Also known as: 911208-73-6, Hdp-tenofovir, Cmx157, Cmx-157, 3-(hexadecyloxy)propyl hydrogen ((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate, Cmx 157
    Molecular Formula
    C28H52N5O5P
    Molecular Weight
    569.7  g/mol
    InChI Key
    SCTJKHUUZLXJIP-RUZDIDTESA-N
    FDA UNII
    K7J545MEMA
    Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid
    2.1.2 InChI
    InChI=1S/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/m1/s1
    2.1.3 InChI Key
    SCTJKHUUZLXJIP-RUZDIDTESA-N
    2.1.4 Canonical SMILES
    CCCCCCCCCCCCCCCCOCCCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)O
    2.1.5 Isomeric SMILES
    CCCCCCCCCCCCCCCCOCCCOP(=O)(CO[C@H](C)CN1C=NC2=C(N=CN=C21)N)O
    2.2 Other Identifiers
    2.2.1 UNII
    K7J545MEMA
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cmx 157

    2. Cmx-157

    3. Cmx157

    4. Hdp-tenofovir

    5. Hexadecyloxypropyl 9-(2-(phosphonomethoxy)propyl)adenine

    2.3.2 Depositor-Supplied Synonyms

    1. 911208-73-6

    2. Hdp-tenofovir

    3. Cmx157

    4. Cmx-157

    5. 3-(hexadecyloxy)propyl Hydrogen ((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

    6. Cmx 157

    7. K7j545mema

    8. 9-r-(2-(phosphonomethoxy)propyl)adenine

    9. Phosphonic Acid, (((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-, Mono(3-(hexadecyloxy)propyl) Ester

    10. Hexadecyloxypropyl Tenofovir

    11. Unii-k7j545mema

    12. Phosphonic Acid, [[(1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methyl]-, Mono[3-(hexadecyloxy)propyl] Ester

    13. Hdp-pmpa

    14. Hdp-(r)-pmpa

    15. Tenofovir Exalidex(cmx157)

    16. Chembl515564

    17. Schembl2299893

    18. Tenofovir Exalidex [inn]

    19. Bdbm77092

    20. Tenofovir Exalidex [who-dd]

    21. Hexadecyloxypropyl Ester Of Tenofovir

    22. Zinc42875215

    23. Db14925

    24. Hy-109014

    25. Cs-0030512

    26. J3.616.616i

    27. Q27282054

    28. Hexadecyloxypropyl 9-(2-(phosphonomethoxy)propyl)adenine

    29. [(1r)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(3-hexadecoxypropoxy)phosphinic Acid

    30. [(2r)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic Acid

    31. 3-(hexadecyloxy)propyl Hydrogen ((((2r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

    32. 3-(hexadecyloxy)propylhydrogen((((r)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

    33. Phosphonic Acid, P-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-, Mono(3(hexadecyloxy)propyl) Ester

    34. Phosphonic Acid, P-(((1r)-2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-, Mono(3-(hexadecyloxy)propyl) Ester

    2.4 Create Date
    2007-12-26
    3 Chemical and Physical Properties
    Molecular Weight 569.7 g/mol
    Molecular Formula C28H52N5O5P
    XLogP36.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count25
    Exact Mass569.37060677 g/mol
    Monoisotopic Mass569.37060677 g/mol
    Topological Polar Surface Area135 Ų
    Heavy Atom Count39
    Formal Charge0
    Complexity650
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-HIV Agents

    Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

    Post Enquiry
    POST ENQUIRY