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    Telitacicept

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    2D Structure
    Also known as: Telitaciceptum, Tai'ai, Telitacicept [inn], Telitacicept [who-dd], 1fhm3d7z49, 2136630-26-5
    Molecular Formula
    C44H26I4N4
    Molecular Weight
    1118.3  g/mol
    InChI Key
    BIHWRSWVZVTYDW-UHFFFAOYSA-N
    Telitacicept is a fusion protein composed of the extracellular domain of human tumor necrosis factor receptor superfamily member 13B (TNFRSF13B; transmembrane activator and calcium modulator and cyclophilin ligand interactor; TACI) fused to a human immunoglobulin (Ig) fragment crystallizable (Fc) domain, with potential immunomodulating activity. Upon administration, telitacicept targets both tumor necrosis factor ligand superfamily member 13B (TNFSF13B; BAFF; B lymphocyte stimulator; BLyS) and tumor necrosis factor ligand superfamily member 13 (TNFSF13; a proliferation-inducing ligand; APRIL) and inhibits their interaction with their cell membrane receptors, including TACI, tumor necrosis factor receptor superfamily member 17 (TNFRSF17; B-cell maturation antigen; BCMA) and tumor necrosis factor receptor superfamily member 13C (TNFRSF13C; BAFF receptor; BAFF-R). This inhibits B-cell proliferation and maturation, thereby inhibiting B-cell mediated autoimmune responses. APRIL and BAFF, and their interactions with their receptors TACI, BCMA and BAFF-R, play important roles in in B-cell proliferation and survival.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5,10,15,20-tetrakis(3-iodophenyl)-21,23-dihydroporphyrin
    2.1.2 InChI
    InChI=1S/C44H26I4N4/c45-29-9-1-5-25(21-29)41-33-13-15-35(49-33)42(26-6-2-10-30(46)22-26)37-17-19-39(51-37)44(28-8-4-12-32(48)24-28)40-20-18-38(52-40)43(36-16-14-34(41)50-36)27-7-3-11-31(47)23-27/h1-24,49,52H
    2.1.3 InChI Key
    BIHWRSWVZVTYDW-UHFFFAOYSA-N
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. Telitaciceptum

    2. Tai'ai

    3. Telitacicept [inn]

    4. Telitacicept [who-dd]

    5. 1fhm3d7z49

    6. 2136630-26-5

    7. (l120>a,l121>e,g123>a,a216>s,p217>s)-taci (transmembrane Activator And Caml Interactor, Tumor Necrosis Factor Receptor Superfamily Protein Tnfrsf13b) Human Extracellular Domain Fragment (13-118)-peptide (1-106) Fusion Protein With Human Immunoglobulin G1

    8. 13-118-tumor Necrosis Factor Receptor Superfamily Protein Tnfrsf13b (human Extracellular Domain Fragment) Fusion Protein With Immunoglobulin G1, (human Rc18 Fc Fragment), Dimer

    9. (l120>a,l121>e,g123>a,a216>s,p217>s)-taci (transmembrane Activator And Caml Interactor, Tumor Necrosis Factor Receptor Superfamily Protein Tnfrsf13b) Human Extracellular Domain Fragment (13-118)-peptide (1-106) Fusion Protein With Human Immunoglobulin G1-(227 C-terminal Residues)-peptide (.gamma.1-chain Fc Fragment) (107-333) (homo Sapiens Ighg1*01, Hinge (107-116), Ch2 L120>a, L121>e, G123>a, A216>s, P217>s (117-226), Ch3 (227-331), Chs (332-333)), (112-112':115-115')-bisdisulfide Dimer,

    10. (l120>a,l121>e,g123>a,a216>s,p217>s)-taci (transmembrane Activator And Caml Interactor, Tumor Necrosis Factor Receptor Superfamily Protein Tnfrsf13b) Human Extracellular Domain Fragment (13-118)-peptide (1-106) Fusion Protein With Human Immunoglobulin G1-(227 C-terminal Residues)-peptide (gamma1-chain Fc Fragment) (107-333) (homo Sapiens Ighg1*01, Hinge (107-116), Ch2 L120>a, L121>e, G123>a, A216>s, P217>s (117-226), Ch3 (227-331), Chs (332-333)), (112-112':115-115')-bisdisulfide Dimer,

    11. 5,10,15,20-tetrakis(3-iodophenyl)porphyrin

    12. 107643-76-5

    13. Tetra-(3-iodophenyl)porphin

    2.3 Create Date
    2019-01-25
    3 Chemical and Physical Properties
    Molecular Weight 1118.3 g/mol
    Molecular Formula C44H26I4N4
    XLogP313
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count4
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area57.4
    Heavy Atom Count52
    Formal Charge0
    Complexity1010
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of Systemic Lupus Erythematosus (SLE)