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    Technical details about TECHNETIUM Tc 99m MEDRONATE, learn more about the structure, uses, toxicity, action, side effects and more

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    TECHNETIUM TC-99M MEDRONATE

    APIs // Active Pharmaceutical Ingredients

    DOSSIERs // Finished Dosage Forms

    PharmaCompass

    Inke S.A: APIs manufacturing plant.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    1. Also known as: Medronic acid, 1984-15-2, Phosphonic acid, methylenebis-, Phosphonomethylphosphonic acid, Medronate, Methanediphosphonic acid
    Molecular Formula
    CH6O6P2
    Molecular Weight
    176.00  g/mol
    InChI Key
    MBKDYNNUVRNNRF-UHFFFAOYSA-N
    FDA UNII
    73OS0QIN3O
    Medronic Acid is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. This agent accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes such as technetium 99m, in bone imaging.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    phosphonomethylphosphonic acid
    2.1.2 InChI
    InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)
    2.1.3 InChI Key
    MBKDYNNUVRNNRF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(P(=O)(O)O)P(=O)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    73OS0QIN3O
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Disodium Methanediphosphonate

    2. Methane Diphosphonate

    3. Methylene Diphosphonate

    4. Methylene Diphosphonate, (32)p-labeled

    5. Methylene Diphosphonate, Disodium Salt

    6. Methylene Diphosphonate, Tetrasodium Salt

    7. Methylene Diphosphonate, Tetrasodium Salt, (32)p-labeled

    8. Methylene Diphosphonate, Tin(4+) Salt, (113)sn-labeled

    9. Methylene Diphosphonate, Trisodium Salt

    10. Methylene Diphosphonic Acid

    2.3.2 Depositor-Supplied Synonyms

    1. Medronic Acid

    2. 1984-15-2

    3. Phosphonic Acid, Methylenebis-

    4. Phosphonomethylphosphonic Acid

    5. Medronate

    6. Methanediphosphonic Acid

    7. Acido Medronico

    8. Acide Medronique

    9. Acidum Medronicum

    10. Methylene Diphosphonic Acid

    11. Methylenebis(phosphonic Acid)

    12. Mdp-bracco

    13. Methanediylbis(phosphonic Acid)

    14. Methanebisphosphonic Acid

    15. Methylene-1,1-bisphosphonic Acid

    16. Einecs 217-851-0

    17. Phosphonic Acid, Methylenedi-

    18. 73os0qin3o

    19. Mls000048571

    20. Chembl180570

    21. (phosphonomethyl)phosphonic Acid

    22. Chebi:43945

    23. Medronic Acid (usan)

    24. Smr000060476

    25. Medronic Acid [usan]

    26. Mdn

    27. Acide Medronique [inn-french]

    28. Acido Medronico [inn-spanish]

    29. Acidum Medronicum [inn-latin]

    30. Unii-73os0qin3o

    31. Medronic-acid

    32. Medronic Acid [usan:inn:ban]

    33. Methylene Diphsphonate

    34. Methandiphosphonic Acid

    35. Opera_id_703

    36. Medronic Acid [ii]

    37. Medronic Acid [mi]

    38. Dsstox_cid_25696

    39. Dsstox_rid_81068

    40. Medronic Acid [inn]

    41. Dsstox_gsid_45696

    42. Schembl66716

    43. Methylene Bis-phosphonic Acid

    44. Mdp, Methanediphosphonic Acid

    45. Bis(dihydroxyphosphoryl)methane

    46. Phosphonomethyl-phosphonic Acid

    47. Medronic Acid [mart.]

    48. Medronic Acid [who-dd]

    49. Dtxsid8045696

    50. Mbkdynnuvrnnrf-uhfffaoysa-

    51. Amy31948

    52. Bcp20495

    53. Methylenediphosphonic Acid, >=99%

    54. Zinc8015016

    55. Tox21_110974

    56. Bdbm50162816

    57. Mfcd00002139

    58. Phosphonic Acid, P,p'-methylenebis-

    59. Stl302043

    60. Akos001031749

    61. Db14078

    62. Ncgc00037856-01

    63. Ncgc00037856-02

    64. Cas-1984-15-2

    65. Methylene Diphosphonic Acid [vandf]

    66. Db-009770

    67. Hy-108309

    68. Cs-0028208

    69. Ft-0628882

    70. M0843

    71. D04887

    72. Diethylenetriaminepentakis(methylphosphonic Acid)

    73. T72027

    74. A928713

    75. Methylenediphosphonic Acidmethylenediphosphonic Acid

    76. Q2823283

    77. Medronic Acid, European Pharmacopoeia (ep) Reference Standard

    78. Methylenediphosphonic Acid, For Molecular Studies & Mass Spectrometry

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 176.00 g/mol
    Molecular Formula CH6O6P2
    XLogP3-3.3
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count2
    Exact Mass175.96396190 g/mol
    Monoisotopic Mass175.96396190 g/mol
    Topological Polar Surface Area115 Ų
    Heavy Atom Count9
    Formal Charge0
    Complexity152
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMdp-bracco
    Active IngredientTechnetium tc-99m medronate kit
    Dosage FormInjectable
    RouteInjection
    Strengthn/a
    Market StatusPrescription
    CompanyBracco

    2 of 2  
    Drug NameMdp-bracco
    Active IngredientTechnetium tc-99m medronate kit
    Dosage FormInjectable
    RouteInjection
    Strengthn/a
    Market StatusPrescription
    CompanyBracco

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

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