Saxagliptin Hydrochloride

ACCESS ALL DATA, CHEMISTRY

ACTIVE PHARMA INGREDIENTS

20 API Suppliers, 12 USDMF, 6 EU WC, 6 NDC API, 5 Listed Suppliers, $ API Reference Price

INTERMEDIATES

2 Intermediate Suppliers

2 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

47 FDF Dossiers, 30 FDA Orange Book, 8 Europe, 9 Canada

DRUG PRODUCT COMPOSITIONS

TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 2.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, EXTENDED RELEASE;ORAL - 500MG;EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 2.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 1 SPI Pharma, 5 DKSH, 4 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 Aeon Procare, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 Ashland, 1 BASF, 1 Clariant, 5 Corel Pharma Chem, 6 DFE Pharma, 7 Gangwal Chemicals, 2 Ideal Cures, 1 Ingredion Pharma Solutions, 17 Kerry, 3 Keval Exports, 1 Kima Chemical, 13 Microlex e.U, 2 Nitika Pharmaceutical Specialities, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 10 Roquette, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 3 Silverline Chemicals, 1 The Dow Chemical Company, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

31 Fillers, Diluents & Binders, 22 Coating Systems & Additives, 19 Direct Compression, 18 Thickeners and Stabilizers, 16 Granulation, 15 Disintegrants & Superdisintegrants, 12 Lubricants & Glidants, 8 Controlled & Modified Release, 8 Co-Processed Excipients, 7 Rheology Modifiers, 6 Film Formers & Plasticizers, 3 Chewable & Orodispersible Aids, 3 Parenteral, 3 Taste Masking, 3 Solubilizers, 3 Topical, 3 Emulsifying Agents, 2 API Stability Enhancers, 2 Coloring Agents, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

11 News #PharmaBuzz

11 News #PharmaBuzz

GLOBAL SALES INFORMATION

8 US Medicaid Prescriptions

8 US Medicaid Prescriptions

MARKET PLACE

2 APIs

2 APIs

PATENTS & EXCLUSIVITIES

82 US Patents, 15 Health Canada Patents

$ Xls

Filters

Also known as: 709031-78-7

Molecular Formula

C₁₈H₂₆ClN₃O₂

Molecular Weight

351.9 g/mol

InChI Key

TUAZNHHHYVBVBR-RIKNOMPASA-N

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,3R)-2-[(2R)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile;hydrochloride

2.1.2 InChI

InChI=1S/C18H25N3O2.ClH/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H/t10?,11?,12?,13-,14-,15+,17?,18?;/m1./s1

2.1.3 InChI Key

TUAZNHHHYVBVBR-RIKNOMPASA-N

2.1.4 Canonical SMILES

C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N.Cl

2.1.5 Isomeric SMILES

C1[C@@H](N([C@H]2C1C2)C(=O)[C@@H](C34CC5CC(C3)CC(C5)(C4)O)N)C#N.Cl

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. 709031-78-7

2.3 Create Date

2012-03-21

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₆ClN₃O₂
Molecular Weight	351.9 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	351.1713548 g/mol
Monoisotopic Mass	351.1713548 g/mol
Topological Polar Surface Area	90.4 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	609
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

Saxagliptin Hydrochloride

Saxagliptin Hydrochloride

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

20 API Suppliers

12 USDMF

6 EU WC

6 NDC API

5 Listed Suppliers

$ API Reference Price

INTERMEDIATES

2 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

47 FDF Dossiers

30 FDA Orange Book

8 Europe

9 Canada

DRUG PRODUCT COMPOSITIONS

TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 2.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET, EXTENDED RELEASE;ORAL - 500MG;EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 2.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

1 SPI Pharma

5 DKSH

4 Gangwal Healthcare

2 Nanjing Well Pharmaceutical

1 Aeon Procare

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 Ashland

1 BASF

1 Clariant

5 Corel Pharma Chem

6 DFE Pharma

7 Gangwal Chemicals

2 Ideal Cures

1 Ingredion Pharma Solutions

17 Kerry

3 Keval Exports

1 Kima Chemical

13 Microlex e.U

2 Nitika Pharmaceutical Specialities

1 Novo Excipients

1 Pharmatrans-Sanaq

3 Pluviaendo

3 Prachin Chemical

10 Roquette

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

10 Sigachi Industries

3 Silverline Chemicals

1 The Dow Chemical Company

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

31 Fillers, Diluents & Binders

22 Coating Systems & Additives

19 Direct Compression

18 Thickeners and Stabilizers

16 Granulation

15 Disintegrants & Superdisintegrants

12 Lubricants & Glidants

8 Controlled & Modified Release

8 Co-Processed Excipients

7 Rheology Modifiers

6 Film Formers & Plasticizers

3 Chewable & Orodispersible Aids

3 Parenteral

3 Taste Masking

3 Solubilizers

3 Topical

3 Emulsifying Agents

2 API Stability Enhancers

2 Coloring Agents

1 Surfactant & Foaming Agents

DIGITAL CONTENT

11 News #PharmaBuzz

TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 2.5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET, EXTENDED RELEASE;ORAL - 500MG;EQ 5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 2.5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

TABLET;ORAL - EQ 5MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons