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    Technical details about Prestwick3_000924, learn more about the structure, uses, toxicity, action, side effects and more

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    Prestwick3_000924

    APIs // Active Pharmaceutical Ingredients

    INTERMEDIATES

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 61413-54-5, (r,s)-rolipram, Zk 62711, Rolipramum [latin], Adeo, (+/-)-rolipram
    Molecular Formula
    C16H21NO3
    Molecular Weight
    275.34  g/mol
    InChI Key
    HJORMJIFDVBMOB-UHFFFAOYSA-N
    FDA UNII
    K676NL63N7
    A phosphodiesterase 4 inhibitor with antidepressant properties.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
    2.1.2 InChI
    InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
    2.1.3 InChI Key
    HJORMJIFDVBMOB-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
    2.2 Other Identifiers
    2.2.1 UNII
    K676NL63N7
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Zk 62711

    2. Zk-62711

    3. Zk62711

    2.3.2 Depositor-Supplied Synonyms

    1. 61413-54-5

    2. (r,s)-rolipram

    3. Zk 62711

    4. Rolipramum [latin]

    5. Adeo

    6. (+/-)-rolipram

    7. Rolipramum

    8. 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

    9. 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

    10. 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

    11. Zk-62711

    12. 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

    13. 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone

    14. Sb 95952

    15. Chembl63

    16. Nsc-760125

    17. 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone

    18. C16h21no3

    19. Mls000069691

    20. Zk 62 711

    21. 2-pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

    22. Chebi:104872

    23. K676nl63n7

    24. Sb-95952

    25. Smr000058510

    26. Zk-62771

    27. (4s)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-pyrrolidin-2-one

    28. (r,s)-rolipram;sb 95952;zk 62711

    29. Dsstox_cid_24124

    30. Dsstox_rid_80104

    31. Dsstox_gsid_44124

    32. 4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one

    33. 2-pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-

    34. (4r)-4-[3-(cyclopentyloxy)-4 Methoxyphenyl)pyrrolidin-2-one

    35. Rolipram [usan:inn]

    36. [3h]rolipram

    37. [3h]-rolipram

    38. Sr-01000000162

    39. Einecs 262-771-1

    40. 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon

    41. Brn 1588548

    42. Unii-k676nl63n7

    43. (plusmn)-rolipram

    44. Ncgc00016899-01

    45. Cas-61413-54-5

    46. Mfcd00270906

    47. R-(-)-rolipram

    48. Me-3167

    49. Rolipram [usan]

    50. Rolipram [inn]

    51. Rolipram [jan]

    52. Rolipram [mi]

    53. Opera_id_1749

    54. Prestwick0_000924

    55. Prestwick1_000924

    56. Prestwick2_000924

    57. Prestwick3_000924

    58. Rolipram [mart.]

    59. Rolipram [who-dd]

    60. Upcmld-dp110

    61. Lopac0_001072

    62. Schembl27930

    63. Bspbio_000828

    64. Bspbio_001356

    65. Kbiogr_000076

    66. Kbioss_000076

    67. Rolipram (jan/usan/inn)

    68. Mls000758273

    69. Mls000759531

    70. Mls001146912

    71. Mls001424084

    72. Mls006010272

    73. Spbio_003007

    74. (+)-rolipram; (s)-rolipram

    75. Bpbio1_000912

    76. Gtpl5260

    77. Gtpl5313

    78. 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one

    79. Dtxsid3044124

    80. Upcmld-dp110:001

    81. Upcmld-dp110:002

    82. Bdbm14361

    83. Kbio2_000076

    84. Kbio2_002644

    85. Kbio2_005212

    86. Kbio3_000151

    87. Kbio3_000152

    88. Bio2_000076

    89. Bio2_000556

    90. Hms1361d18

    91. Hms1570j10

    92. Hms1791d18

    93. Hms1989d18

    94. Hms2051n15

    95. Hms2090j16

    96. Hms2097j10

    97. Hms2232f06

    98. Hms3263g06

    99. Hms3267a05

    100. Hms3369j08

    101. Hms3393n15

    102. Hms3402d18

    103. Hms3411f08

    104. Hms3654p06

    105. Hms3655j21

    106. Hms3675f08

    107. Hms3714j10

    108. Pharmakon1600-01505683

    109. Bcp21910

    110. Bcp23388

    111. Tox21_110672

    112. Tox21_501072

    113. Nsc760125

    114. Rolipram, Solid, >=98% (hplc)

    115. S1430

    116. Rolipram - Cas 61413-54-5

    117. Akos015959793

    118. Tox21_110672_1

    119. Ccg-100965

    120. Ccg-205149

    121. Cs-1754

    122. Db01954

    123. Ks-1400

    124. Lp01072

    125. Nc00215

    126. Nsc 760125

    127. Sb12922

    128. Sdccgsbi-0051042.p003

    129. Idi1_033826

    130. Ncgc00015898-03

    131. Ncgc00015898-04

    132. Ncgc00015898-05

    133. Ncgc00015898-06

    134. Ncgc00015898-07

    135. Ncgc00015898-08

    136. Ncgc00015898-09

    137. Ncgc00015898-11

    138. Ncgc00015898-12

    139. Ncgc00015898-15

    140. Ncgc00015898-31

    141. Ncgc00089796-02

    142. Ncgc00089796-04

    143. Ncgc00089796-05

    144. Ncgc00089796-06

    145. Ncgc00089796-07

    146. Ncgc00089796-08

    147. Ncgc00261757-01

    148. Ac-32927

    149. Hy-16900

    150. Sbi-0051042.p002

    151. Db-080675

    152. Ab00513966

    153. Eu-0101072

    154. Ft-0738515

    155. R0110

    156. Sw196583-4

    157. D01783

    158. R 6520

    159. Ab00384360-17

    160. Ab00384360_19

    161. A847969

    162. Q410285

    163. 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidinone

    164. Sr-01000000162-3

    165. Sr-01000000162-4

    166. Sr-01000000162-5

    167. Sr-01000000162-9

    168. 4-[3-cyclopentyloxy-4-methoxyphenyl]-2-pyrrolidinone

    169. Brd-a34255068-001-04-8

    170. Brd-a34255068-001-26-1

    171. Sr-01000000162-12

    172. 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one

    173. 4-(3-cyclopentyloxy-4-methoxyphenyl)-pyrrolidin-2-one

    174. 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidone

    175. 4-[4-methoxy-3-(cyclopentyloxy)phenyl]-2-pyrrolidinone

    176. 2-pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]- (9ci)

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 275.34 g/mol
    Molecular Formula C16H21NO3
    XLogP32.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass275.15214353 g/mol
    Monoisotopic Mass275.15214353 g/mol
    Topological Polar Surface Area47.6 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity341
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Phosphodiesterase 4 Inhibitors

    Compounds that specifically inhibit PHOSPHODIESTERASE 4. (See all compounds classified as Phosphodiesterase 4 Inhibitors.)

    Antidepressive Agents

    Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

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