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    Technical details about Prestwick3_000484, learn more about the structure, uses, toxicity, action, side effects and more

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    Prestwick3_000484

    APIs // Active Pharmaceutical Ingredients

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

    ANALYTICAL SOLUTION(s)

    PharmaCompass

    Phyton is a World Leader in Plant Cell Fermentation Technology and Commercial Manufacturing.

    Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

    2D Structure
    Also known as: 2062-84-2, Anquil, Frenactil, Glianimon, Frenactyl, Concilium
    Molecular Formula
    C22H24FN3O2
    Molecular Weight
    381.4  g/mol
    InChI Key
    FEBOTPHFXYHVPL-UHFFFAOYSA-N
    FDA UNII
    97O6X78C53
    A butyrophenone with general properties similar to those of HALOPERIDOL. It has been used in the treatment of aberrant sexual behavior. (From Martindale, The Extra Pharmacopoeia, 30th ed, p567)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-1H-benzimidazol-2-one
    2.1.2 InChI
    InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
    2.1.3 InChI Key
    FEBOTPHFXYHVPL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
    2.2 Other Identifiers
    2.2.1 UNII
    97O6X78C53
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anquil

    2. Benperidol Neuraxpharm

    3. Benperidol-neuraxpharm

    4. Benperidolneuraxpharm

    5. Frenactil

    6. Glianimon

    2.3.2 Depositor-Supplied Synonyms

    1. 2062-84-2

    2. Anquil

    3. Frenactil

    4. Glianimon

    5. Frenactyl

    6. Concilium

    7. Mcn-jr-4584

    8. Benzoperidol

    9. Benzperidol

    10. Glianimon Mite

    11. R-4584

    12. Benzeridol

    13. R 4584

    14. Cb 8089

    15. 8089 C. B.

    16. 2h-benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-

    17. Nsc-170982

    18. 2h-benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl)-1,3-dihydro-

    19. 8089 C.b.

    20. 1-(1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl)-2-benzimidazolinone

    21. 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-1h-benzimidazol-2-one

    22. Nsc170982

    23. 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1h-benzo[d]imidazol-2(3h)-one

    24. 97o6x78c53

    25. Ncgc00016602-01

    26. Cas-2062-84-2

    27. 2-benzimidazolinone, 1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-

    28. Dsstox_cid_25364

    29. Dsstox_rid_80827

    30. Dsstox_gsid_45364

    31. 983-42-6

    32. Anquil (van)

    33. Benperidolo [dcit]

    34. Benperidolo

    35. Benperidolum

    36. 1-{1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl}-2-benzimidazolinone

    37. 2-benzimidazolinone, 1-(1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl)-

    38. 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1h-benzimidazol-2-one

    39. Benperidolum [inn-latin]

    40. 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazol-2-one

    41. 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one

    42. 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-2h-benzimidazol-2-one

    43. Benperidol [usan:inn:ban]

    44. Mcn-jr 4584

    45. Einecs 218-172-2

    46. Nsc 170982

    47. Brn 0900981

    48. Benquil

    49. 1-1-(3-(p-fluorobenzoyl)propyl)-4-piperidyl-2-benzimidazolinone

    50. 1-1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl-2-benzimidazolinone

    51. Unii-97o6x78c53

    52. 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl)-1,3-dihydro-2h-benzimidazol-2-one

    53. Anquil Hydrochloride

    54. Prestwick_778

    55. Anquil (tn)

    56. Frenactyl Hydrochloride

    57. Benperidol [mi]

    58. Benzperidol Hydrochloride

    59. Benperidol [inn]

    60. 4'-fluor-4-(4-(2-oxo-1-benzimidazolinyl)piperidino)butyrophenon

    61. Benperidol (usan/inn)

    62. Prestwick0_000484

    63. Prestwick1_000484

    64. Prestwick2_000484

    65. Prestwick3_000484

    66. Benperidol [usan]

    67. Benperidol [mart.]

    68. Benperidol [who-dd]

    69. Bspbio_000347

    70. 5-24-02-00375 (beilstein Handbook Reference)

    71. Mls002153837

    72. Schembl122650

    73. Spbio_002268

    74. Bpbio1_000383

    75. Chembl297302

    76. Gtpl9215

    77. Dtxsid7045364

    78. Bdbm81492

    79. Chebi:93403

    80. Benperidol [ep Monograph]

    81. 2-benzimidazolinone, Hydrochloride

    82. Hms1569b09

    83. Hms2096b09

    84. Hms2235h20

    85. Hms3374b03

    86. Hms3713b09

    87. Zinc9232411

    88. Tox21_110517

    89. Bdbm50183266

    90. Nsc_16363

    91. Nsc169873

    92. Pdsp1_000835

    93. Pdsp2_000822

    94. 3-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidyl]-1h-benzimidazol-2-one

    95. Akos016339645

    96. Tox21_110517_1

    97. Ccg-220484

    98. Db12867

    99. Ks-1335

    100. Nsc-169873

    101. Ncgc00016602-02

    102. Ncgc00016602-04

    103. Ac-12200

    104. Smr001233200

    105. Cas_2062-84-2

    106. Db-045313

    107. Hy-121276

    108. 2-benzimidazolinone, Hydrochloridemonohydrate

    109. Cs-0081352

    110. Ft-0634013

    111. Wln: T56 Bmvnj D- Dt6ntj A3vr Df

    112. D02627

    113. 062b842

    114. A814756

    115. L000947

    116. Q424412

    117. Sr-01000841254

    118. 2h-benzimidazol-2-one,3-dihydro-, Monohydrochloride

    119. Sr-01000841254-2

    120. Brd-k79425933-001-03-6

    121. {1-1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl-2-benzimidazolinone}

    122. 1-[1-[3-(p-fluorbenzoyl)propyl]-4-piperidyl]-2-benzimidazolinon

    123. 2-benzimidazolinone, {1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-}

    124. Gamma-[4-(2-oxo-1-benzimidazolinyl)-piperidino]-p-fluorobutyrophenone

    125. 1-[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidyl]-3h-benzoimidazol-2-one

    126. 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1h-benzo[d] Imidazol-2(3h)-one

    127. 2-benzimidazolinone, {1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-,} Hydrochloridemonohydrate

    128. 2h-benzimidazol-2-one, {1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-}

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 381.4 g/mol
    Molecular Formula C22H24FN3O2
    XLogP33.7
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count6
    Exact Mass381.18525518 g/mol
    Monoisotopic Mass381.18525518 g/mol
    Topological Polar Surface Area52.6 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity556
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    4.2 ATC Code

    N05AD07

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N05 - Psycholeptics

    N05A - Antipsychotics

    N05AD - Butyrophenone derivatives

    N05AD07 - Benperidol

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