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1. Alphadine
2. Alphadines
3. Betadine
4. Betadines
5. Betaisodona
6. Disadine
7. Disadines
8. Isodine
9. Isodines
10. Pharmadine
11. Pharmadines
12. Polyvinylpyrrolidone Iodine
13. Polyvinylpyrrolidone Iodines
14. Povidone-iodine
15. Povidone-iodines
16. Providine
17. Providines
18. Pvp Iodine
19. Pvp-i
20. Pvp-iodine
21. Pvp-iodines
1. 25655-41-8
2. Povidone-iodine
3. Betadine
4. Isodine
5. Pvp Iodine
6. Pvp-iodine
7. Pvp-i
8. Isobetadyne
9. Bridine
10. Disphex
11. Povadyne
12. Ultradine
13. Efo-dine
14. Iodopoly(vinyl Pyrrolidinone)
15. 1-ethenylpyrrolidin-2-one;molecular Iodine
16. Nsc26245
17. 2-pyrrolidinone, 1-ethenyl-, Homopolymer, Compd. With Iodineother Ca Index Names:iodine, Compd. With 1-ethenyl-2-pyrrolidinone Homopolymer
18. Iodine-poly(vinylpyrrolidinone)
19. Poly(vinylpyrrolidinone) Iodide
20. Iodinated Poly(vinylpyrrolidone)
21. Poly(vinylpyrrolidone)-iodine Adduct
22. Poly(vinylpyrrolidinone)-iodine Complex
23. Poly(vinylpyrrolidone) - Iodine Complex
24. Polyvinylpyrrolidone Compound With Iodine
25. Povidone.iodine
26. 1-ethenyl-2-pyrrolidinone Homopolymer Compound With Iodine
27. Molecular Iodine; 1-vinylpyrrolidin-2-one
28. 1-ethenylpyrrolidin-2-one; Molecular Iodine
29. Povidone Iodine-ip, 9-12%
30. Schembl1652685
31. Bcp28568
32. Nsc28655
33. Mfcd00084483
34. Nsc-26245
35. Nsc-28655
36. Akos015898248
37. Polyvinylpyrrolidone-iodinecomplex
38. 1-ethenyl-2-pyrrolidinone; Molecular Iodine
39. Ft-0655804
40. 2-pyrrolidinone, Polymers, Compd. With Iodine
41. A16118
42. 2-pyrrolidinone, Homopolymer, Compd. With Iodine
43. A817952
44. Q241516
45. 1-vinylpyrrolidin-2-one Compound With Diiodine (1:1)
46. Poly[1-(2-oxo-1-pyrrolidinyl)ethylene]iodine Complex
47. Povidone (iodinated), European Pharmacopoeia (ep) Reference Standard
| Molecular Weight | 364.95 g/mol |
|---|---|
| Molecular Formula | C6H9I2NO |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 1 |
| Exact Mass | 364.87736 g/mol |
| Monoisotopic Mass | 364.87736 g/mol |
| Topological Polar Surface Area | 20.3 Ų |
| Heavy Atom Count | 10 |
| Formal Charge | 0 |
| Complexity | 120 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
| 1 of 4 | |
|---|---|
| Drug Name | Betadine |
| PubMed Health | Povidone Iodine (Into the eye) |
| Drug Classes | Antiseptic |
| Drug Label | Povidone-Iodine is a broad-spectrum microbicide with the chemical formulas:2-pyrrolidinone, 1- ethenyl-, homopolymer, compound with iodine; 1-vinyl-2-pyrrolidinone polymer, compound with iodine. The structural formula is as follows:BETADINE 5% Ster... |
| Active Ingredient | Povidone-iodine |
| Dosage Form | Solution/drops |
| Route | Ophthalmic |
| Strength | 5% |
| Market Status | Prescription |
| Company | Alcon Pharms |
| 2 of 4 | |
|---|---|
| Drug Name | Povidone iodine |
| PubMed Health | Povidone Iodine (Into the eye) |
| Drug Classes | Antiseptic |
| Drug Label | Other InformationStore below 98F/37C avoid direct heat and sunlight... |
| Active Ingredient | Povidone-iodine |
| Dosage Form | Solution |
| Route | Topical |
| Strength | 1% |
| Market Status | Over the Counter |
| Company | Allegiance Hlthcare |
| 3 of 4 | |
|---|---|
| Drug Name | Betadine |
| PubMed Health | Povidone Iodine (Into the eye) |
| Drug Classes | Antiseptic |
| Drug Label | Povidone-Iodine is a broad-spectrum microbicide with the chemical formulas:2-pyrrolidinone, 1- ethenyl-, homopolymer, compound with iodine; 1-vinyl-2-pyrrolidinone polymer, compound with iodine. The structural formula is as follows:BETADINE 5% Ster... |
| Active Ingredient | Povidone-iodine |
| Dosage Form | Solution/drops |
| Route | Ophthalmic |
| Strength | 5% |
| Market Status | Prescription |
| Company | Alcon Pharms |
| 4 of 4 | |
|---|---|
| Drug Name | Povidone iodine |
| PubMed Health | Povidone Iodine (Into the eye) |
| Drug Classes | Antiseptic |
| Drug Label | Other InformationStore below 98F/37C avoid direct heat and sunlight... |
| Active Ingredient | Povidone-iodine |
| Dosage Form | Solution |
| Route | Topical |
| Strength | 1% |
| Market Status | Over the Counter |
| Company | Allegiance Hlthcare |
Anti-Infective Agents, Local
National Library of Medicine's Medical Subject Headings online file (MeSH, 2014)
Povidone-iodine is an iodophore that is used as a disinfectant and antiseptic mainly for the treatment of contaminated wounds and pre-operative preparation of the skin and mucous membranes as well as for disinfection of equipment.
SWEETMAN, S.C. (ed.) Martindale-The Complete Drug Reference. 36th ed. London: The Pharmaceutical Press, 2009., p. 1659
BETADINE 5% Sterile Ophthalmic Prep Solution for the eye is indicated for prepping of the periocular region (lids, brow, and cheek) and irrigation of the ocular surface (cornea, conjunctiva, and palpebral fornices).
NIH; DailyMed. Current Medication Information for BETADINE- povidone-iodine solution (Revised: July 2011). Available from, as of October 14, 2014: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b026de1b-9949-4557-ac49-c7b0038c24cd
No studies are available in patients with thyroid disorders; therefore, caution is advised in using BETADINE 5% Sterile Ophthalmic Prep Solution in these patients due to the possibility of iodine absorption.
NIH; DailyMed. Current Medication Information for BETADINE- povidone-iodine solution (Revised: July 2011). Available from, as of October 14, 2014: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b026de1b-9949-4557-ac49-c7b0038c24cd
Because of the potential for serious adverse reactions in nursing infants from BETADINE 5% Sterile Ophthalmic Prep Solution, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
NIH; DailyMed. Current Medication Information for BETADINE- povidone-iodine solution (Revised: July 2011). Available from, as of October 14, 2014: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b026de1b-9949-4557-ac49-c7b0038c24cd
FDA Pregnancy Risk Category: C /RISK CANNOT BE RULED OUT. Adequate, well controlled human studies are lacking, and animal studies have shown risk to the fetus or are lacking as well. There is a chance of fetal harm if the drug is given during pregnancy; but the potential benefits may outweigh the potential risk./
NIH; DailyMed. Current Medication Information for BETADINE- povidone-iodine solution (Revised: July 2011). Available from, as of October 14, 2014: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b026de1b-9949-4557-ac49-c7b0038c24cd
For external use only. Not for intraocular injection or irrigation.
NIH; DailyMed. Current Medication Information for BETADINE- povidone-iodine solution (Revised: July 2011). Available from, as of October 14, 2014: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b026de1b-9949-4557-ac49-c7b0038c24cd
For more Drug Warnings (Complete) data for Povidone-iodine (9 total), please visit the HSDB record page.
For topical application in the treatment and prevention of infection in wounds.
Povidone iodine is a kind of iodine disinfectant which directly cause in vivo protein denaturation, precipitation of bacteria, and further resulting in the death of pathogenic microorganisms. Therefore, it is effective in disinfection and sterilization. It can kill viruses, bacteria, spores, fungi, and protozoa with low toxicity to human. Povidone-iodine aqueous solution has strong pharmacological activity against Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, syphilis, hepatitis B virus, HIV, and Trichomonas vaginalis. Povidone iodine gel is a gynecological topical semi-mobile colloidal agent made by povidone iodine and hydrophilic matrix. It is a system for maintaining its sustained release. Owing to the continuous release of free iodine, it can enable the skin and mucous membranes to maintain a certain effective concentration of iodine for killing bacteria. It is mainly used for gynecological vaginal infection. It exerted its effect through being miscible with vaginal secretions and further killing the inside pathogenic microorganisms, and thus blocking the spread of sexually transmitted diseases and invasion, as well as treating other infected vaginal diseases caused by other kinds of bacteria. Published reports on the in vitro antimicrobial efficacy of iodophors demonstrate that iodophors are bactericidal, mycobactericidal, and virucidal but can require prolonged contact times to kill certain fungi and bacterial spores. Three brands of povidone-iodine solution have demonstrated more rapid kill (seconds to minutes) of S. aureus and M. chelonae at a 1:100 dilution than did the stock solution. The virucidal activity of 75150 ppm available iodine was demonstrated against seven viruses. Other investigators have questioned the efficacy of iodophors against poliovirus in the presence of organic matter and rotavirus in distilled or tapwater. Manufacturers' data demonstrate that commercial iodophors are not sporicidal, but they are tuberculocidal, fungicidal, virucidal, and bactericidal at their recommended use-dilution.
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)
D - Dermatologicals
D08 - Antiseptics and disinfectants
D08A - Antiseptics and disinfectants
D08AG - Iodine products
D08AG02 - Povidone-iodine
D - Dermatologicals
D09 - Medicated dressings
D09A - Medicated dressings
D09AA - Medicated dressings with antiinfectives
D09AA09 - Povidone-iodine
D - Dermatologicals
D11 - Other dermatological preparations
D11A - Other dermatological preparations
D11AC - Medicated shampoos
D11AC06 - Povidone-iodine
G - Genito urinary system and sex hormones
G01 - Gynecological antiinfectives and antiseptics
G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids
G01AX - Other antiinfectives and antiseptics
G01AX11 - Povidone-iodine
R - Respiratory system
R02 - Throat preparations
R02A - Throat preparations
R02AA - Antiseptics
R02AA15 - Povidone-iodine
S - Sensory organs
S01 - Ophthalmologicals
S01A - Antiinfectives
S01AX - Other antiinfectives
S01AX18 - Povidone-iodine
Absorption
Povidone-Iodine is intended for topical application and is not absorbed.
Route of Elimination
Povidone-Iodine is intended for topical application and is not eliminated.
Volume of Distribution
Povidone-Iodine is intended for topical application and has no volume of distribution.
Clearance
Povidone-Iodine is intended for topical application and is not eliminated.
Topical application of povidone iodine on the umbilical cord and normal intact skin of newborn infants resulted in significantly elevated plasma iodine levels. High iodine levels were also found in two neonates who had povidone iodine applied to denuded skin. No significant alteration in thyroid function was seen. The possible toxic manifestations of high plasma iodine levels are discussed.
PMID:909027 Pyati SP et al; J Pediatr. 91 (5): 825-8 (1977)
In 12 nonpregnant women, total iodine, protein-bound iodine, inorganic iodine, and thyroxine values were measured in serum before and 15, 30, 45 or 60 minutes after a two-minute vaginal disinfection with povidone-iodine (Betadine). Only 15 minutes after application, serum iodine levels were raised and remained significantly elevated 30, 45 and 60 minutes after disinfection. Serum concentrations of total iodine and inorganic iodine were increased up to fivefold to 15-fold, respectively; during the relative short period of observation, thyroxine levels were not altered.
PMID:7431610 Vorherr H et al; JAMA. 244 (23): 2628-9 (1980)
Povidone-Iodine is not absorbed or metabolized.
Povidone-Iodine is intended for topical application and is not eliminated.
Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine (I2) penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated. _In vitro_ evidence suggests that iodine also counteracts inflammation elicited by both pathogens and the host response via multifactorial effects. In hosts, povidone-iodine was demonstrated to modulate the redox potential, inhibit the release of inflammatory mediators such as TNF- and -galactosidase, inhibit metalloproteinase production, and potentiate the healing signals from pro-inflammatory cytokines by activation of monocytes, T-lymphocytes, and macrophages, _in vitro_.
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