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Technical details about Potassium Dichromate, learn more about the structure, uses, toxicity, action, side effects and more

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2D Structure
1. Also known as: 7778-50-9, Potassium bichromate, Kaliumdichromat, Potassium dichromate(vi), Dipotassium bichromate, Dipotassium dichromate
Molecular Formula
Cr2K2O7
Molecular Weight
294.18  g/mol
InChI Key
KMUONIBRACKNSN-UHFFFAOYSA-N
FDA UNII
T4423S18FM

Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
dipotassium;oxido-(oxido(dioxo)chromio)oxy-dioxochromium
2.1.2 InChI
InChI=1S/2Cr.2K.7O/q;;2*+1;;;;;;2*-1
2.1.3 InChI Key
KMUONIBRACKNSN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[O-][Cr](=O)(=O)O[Cr](=O)(=O)[O-].[K+].[K+]
2.2 Other Identifiers
2.2.1 UNII
T4423S18FM
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bichromate, Potassium

2. Dichromate, Potassium

3. K2cr2o7

4. Potassium Bichromate

2.3.2 Depositor-Supplied Synonyms

1. 7778-50-9

2. Potassium Bichromate

3. Kaliumdichromat

4. Potassium Dichromate(vi)

5. Dipotassium Bichromate

6. Dipotassium Dichromate

7. Dichromic Acid Dipotassium Salt

8. Dipotassium Dichromium Heptaoxide

9. Chromium Potassium Oxide

10. Iopezite

11. Chebi:53444

12. T4423s18fm

13. Mfcd00011367

14. Dipotassium;oxido-(oxido(dioxo)chromio)oxy-dioxochromium

15. Dsstox_cid_5948

16. Dsstox_rid_77973

17. Dsstox_gsid_25948

18. Caswell No. 690

19. Kaliumdichromat [german]

20. Chromium, Reference Standard Solution

21. Kalium Bichromicum

22. Srm 935a

23. Cas-7778-50-9

24. Ccris 2409

25. Hsdb 1238

26. Einecs 231-906-6

27. Nsc 77372

28. K2cr2o7

29. Epa Pesticide Chemical Code 068302

30. Unii-t4423s18fm

31. Kali Bichromicum

32. Potassium Dichromate(2-)

33. Epitope Id:119680

34. Ec 231-906-6

35. Chromic Acid (h2cr2o7) Potassium Salt (1:2)

36. Potassium Dichromate Solution

37. Potassium Dichromate Acs Grade

38. Potassium Dichromate [chromium And Chromium Compounds]

39. Kali Bichromicum [hpus]

40. Dtxsid5025948

41. Potassium Dichromate [hsdb]

42. Potassium Dichromate [vandf]

43. Tox21_111009

44. Tox21_202307

45. Potassium Dichromate [mart.]

46. Potassium Dichromate, Puriss., 99%

47. Potassium Dichromate [who-dd]

48. Akos024418771

49. Potassium Dichromate(vi) [mi]

50. Potassium Dichromate, Ar, >=99.9%

51. Potassium Dichromate, Lr, >=99.5%

52. Potassium Dichromate Solution, 1/60 M

53. Ncgc00090755-01

54. Ncgc00259856-01

55. Potassium Dichromate, Bioxtra, >=99.5%

56. Ft-0698964

57. Potassium Dichromate, Acs Reagent, >=99.0%

58. Potassium Dichromate, 0.1n Standardized Solution

59. Potassium Dichromate, Bioultra, >=99.5% (rt)

60. Potassium Dichromate, Reagentplus(r), >=99.5%

61. Chromic Acid (h2cr2o7), Potassium Salt (1:2)

62. Potassium Dichromate, 0.25n Standardized Solution

63. Potassium Dichromate, 99.99% Trace Metals Basis

64. Potassium Dichromate, Saj First Grade, >=99.5%

65. Q239729

66. Potassium Dichromate, 0.025n Standardized Solution

67. Potassium Dichromate, Jis Special Grade, >=99.5%

68. Potassium Dichromate, Yanagishima Pharmaceutical Co. Ltd.

69. Potassium Dichromate, Nist(r) Srm(r) 136f, Oxidimetric Standard

70. Potassium Dichromate, Nist(r) Srm(r) 935a, Uv Absorbance Standard

71. Potassium Dichromate, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=99.8%

72. Chromium Standard Solution, Suitable For Atomic Absorption Spectrometry, 1 Mg/ml Cr, 1000 Ppm Cr

73. Potassium Dichromate, Certified Reference Material For Titrimetry, Certified By Bam According To Iso 17025, >=99.5%

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 294.18 g/mol
Molecular Formula Cr2K2O7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count0
Exact Mass293.772825 g/mol
Monoisotopic Mass293.772825 g/mol
Topological Polar Surface Area124 Ų
Heavy Atom Count11
Formal Charge0
Complexity194
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Therapeutic Uses

Anti-Infective Agents, Local; Astringents; Caustics; Dyes

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


/CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Potassium dichromate is included in the database.

NIH/NLM; ClinicalTrials.Gov. Available from, as of March 17, 2016: https://clinicaltrials.gov/ct2/results?term=potassium+dichromate&Search=Search


Medication (vet): caustic

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1419


MEDICATION (VET): HAS BEEN USED IN ANTITUSSIVE & LYMPHANGITIS MIXTURES; 20 PPM IN FISH TANK WATER TO CONTROL PROTOZOA & FLUKES

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 473


4.2 Minimum/Potential Fatal Human Dose

4 OR 5. 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG; BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB); 5= EXTREMELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-50 MG/KG; BETWEEN 7 DROPS & 1 TEASPOONFUL FOR 70 KG PERSON (150 LB)

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-76


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Caustics

Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year. (See all compounds classified as Caustics.)


Coloring Agents

Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)


5.2 Absorption, Distribution and Excretion

The acute and subacute toxicities of several Cr(III) and Cr(VI) compounds (chromium(3+) chloride, chromium(3+) nitrate, chromium(3+) sulfate, chromium trioxide, potassium dichromate) were determined in NZC and (CxO) mice injected ip. The distal median lethal doses (> 10 days after treatment) averaged (17.9 + or - 1.8) X 10(-6) g chromium/g body wt regardless of the oxidation state of the Cr compound injected (chromium(3+) sulfate may be an exception), but acute toxicity (3 days) was much greater with Cr(VI) compounds. Acid digests of entire male mice that were administered ip 1/6 of the distal LD50, either once or repeatedly at weekly intervals, were analyzed to determine the whole body persistence and clearance kinetics of Cr. Mice dosed once with Cr(III) retained 6.5 times more chromium at 21 days than mice treated with Cr(VI). When Cr(III) was given at weekly intervals mice accumulated 6 times more Cr by 8 wk than Cr(VI)-treated mice, though only the latter showed symptoms of chromic toxicity. Whole body Cr concentrations continued to rise with further Cr(III) treatments, but slowly declined with Cr(VI). Analyses of fecal and urinary excretion confirmed that most of the urinary Cr excretion from Cr(VI)-treated animals was much faster in both urine and feces than from mice given Cr(III). The differential storage and clearance kinetics of Cr(III) and Cr(VI) compounds may be significant in experimental Cr carcinogenesis studies and in the toxicology of Cr in workers exposed industrially to potentially carcinogenic chromium-containing dusts or aerosols.

PMID:6652867 Bryson WG, Goodall CM; Carcinogenesis 4 (12): 1535-40 (1983)


The interaction of potassium dichromate (Cr(VI)) with bovine serum albumin (BSA) was investigated by fluorescence, synchronous fluorescence, resonance light scattering (RLS), ultraviolet-visible absorption, and circular dichroism (CD) spectroscopies under simulated physiological conditions. The experimental results showed that Cr(VI) could quench the intrinsic fluorescence of BSA following a static quenching process, which indicates the formation of a Cr(VI)-BSA complex. The binding constant (KA) and binding site (n) were measured at different temperatures. The spectroscopic results also revealed that the binding of Cr(VI) to BSA can lead to the loosening of the protein conformation and can change the microenvironment and skeleton of BSA.

PMID:22095857 Zhang P et al; J Biochem Mol Toxicol 26 (2): 54-9 (2012)


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