Polymyxin B Sulfate

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ACTIVE PHARMA INGREDIENTS

50 API Suppliers, 15 USDMF, 8 CEP/COS, 2 JDMF, 2 EU WC, 2 KDMF, 19 NDC API, 25 Listed Suppliers, $ API Reference Price

DEVELOPMENTS

12 Drugs in Development

12 Drugs in Development

FINISHED DOSAGE FORMULATIONS

178 FDF Dossiers, 96 FDA Orange Book, 36 Europe, 19 Canada, 8 South Africa, 19 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM, OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, OINTMENT;OPHTHALMIC - 400 UNITS/GM;EQ 3.5MG BASE/GM;10,000 UNITS/GM, SOLUTION/DROPS;OPHTHALMIC - 10,000 UNITS/ML;EQ 1MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

2 EUROAPI, 1 SPI Pharma, 5 DKSH, 8 Nanjing Well Pharmaceutical, 1 Shanghai Minbiotech, 1 Pfanstiehl, 9 Kirsch Pharma, 1 ACG Worldwide, 17 Actylis, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 24 BASF, 2 CD Formulation, 10 Corel Pharma Chem, 2 Esteem Industries, 3 Finar, 9 Gangwal Chemicals, 3 Ideal Cures, 11 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 4 Microlex e.U, 2 Nanjing Bold Chemical, 2 Nippon Fine Chemical, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pluviaendo, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 5 Roquette, 17 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Sigachi Industries, 2 The Dow Chemical Company, 1 Valens Pharmachem

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40 Coating Systems & Additives, 39 Topical, 35 Solubilizers, 27 Thickeners and Stabilizers, 27 Parenteral, 20 Emulsifying Agents, 16 Controlled & Modified Release, 14 Film Formers & Plasticizers, 13 Surfactant & Foaming Agents, 8 Fillers, Diluents & Binders, 8 Direct Compression, 7 Granulation, 5 Empty Capsules, 5 API Stability Enhancers, 5 Rheology Modifiers, 5 Lubricants & Glidants, 4 Co-Processed Excipients, 4 Vegetarian Capsules, 3 Taste Masking, 3 Chewable & Orodispersible Aids, 2 Coloring Agents, 1 Disintegrants & Superdisintegrants

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14 News #PharmaBuzz

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32 APIs, 7 FDF Dossiers

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Also known as: Polymyxin b, sulfate (salt), 1405-20-5, Polymixin b sulphate, Ks-1428, Pmb, Akos025392172

Molecular Formula

C₅₆H₁₀₀N₁₆O₁₇S

Molecular Weight

1301.6 g/mol

InChI Key

HFMDLUQUEXNBOP-OLYKAHIFSA-N

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid

2.1.2 InChI

InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)/t32?,33-,34-,36+,37+,38-,39+,40+,41+,42+,43-,45+,46+;/m1./s1

2.1.3 InChI Key

HFMDLUQUEXNBOP-OLYKAHIFSA-N

2.1.4 Canonical SMILES

CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)[C@@H](C)O.OS(=O)(=O)O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Polymyxin B, Sulfate (salt)

2. 1405-20-5

3. Polymixin B Sulphate

4. Ks-1428

5. Pmb

6. Akos025392172

7. Polymyxin B Sulfate, Bacillus Polymyxa

8. M02428

9. Polymyxin B Sulfate (1404-26-8 Free Base)

10. 405p205

2.3 Create Date

2010-12-22

3 Chemical and Physical Properties

Molecular Formula	C₅₆H₁₀₀N₁₆O₁₇S
Molecular Weight	1301.6 g/mol
Hydrogen Bond Donor Count	20
Hydrogen Bond Acceptor Count	22
Rotatable Bond Count	29
Exact Mass	1300.71730696 g/mol
Monoisotopic Mass	1300.71730696 g/mol
Topological Polar Surface Area	574 Å²
Heavy Atom Count	90
Formal Charge	0
Complexity	2240
Isotope Atom Count	0
Defined Atom Stereocenter Count	12
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Polymyxin b sulfate
Drug Label	Polymyxin B for Injection, USP is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B sulfate is the sulfate salt of Polymyxins B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmow...
Active Ingredient	Polymyxin b sulfate
Dosage Form	Injectable
Route	Injection
Strength	eq 500,000 u base/vial
Market Status	Prescription
Company	X Gen Pharms; Xellia Pharms Aps; Fresenius Kabi Usa; Eurohlth Intl

2 of 2
Drug Name	Polymyxin b sulfate
Drug Label	Polymyxin B for Injection, USP is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B sulfate is the sulfate salt of Polymyxins B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmow...
Active Ingredient	Polymyxin b sulfate
Dosage Form	Injectable
Route	Injection
Strength	eq 500,000 u base/vial
Market Status	Prescription
Company	X Gen Pharms; Xellia Pharms Aps; Fresenius Kabi Usa; Eurohlth Intl

Polymyxin B Sulfate

Polymyxin B Sulfate

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

50 API Suppliers

15 USDMF

8 CEP/COS

2 JDMF

2 EU WC

2 KDMF

19 NDC API

25 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

12 Drugs in Development

FINISHED DOSAGE FORMULATIONS

178 FDF Dossiers

96 FDA Orange Book

36 Europe

19 Canada

8 South Africa

19 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM

OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

OINTMENT;OPHTHALMIC - 400 UNITS/GM;EQ 3.5MG BASE/GM;10,000 UNITS/GM

SOLUTION/DROPS;OPHTHALMIC - 10,000 UNITS/ML;EQ 1MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

2 EUROAPI

1 SPI Pharma

5 DKSH

8 Nanjing Well Pharmaceutical

1 Shanghai Minbiotech

1 Pfanstiehl

9 Kirsch Pharma

1 ACG Worldwide

17 Actylis

2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

24 BASF

2 CD Formulation

10 Corel Pharma Chem

2 Esteem Industries

3 Finar

9 Gangwal Chemicals

3 Ideal Cures

11 Kerry

3 Kima Chemical

6 Lonza Capsugel

4 Microlex e.U

2 Nanjing Bold Chemical

2 Nippon Fine Chemical

2 Nomisma Healthcare

1 Novo Excipients

1 Pluviaendo

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

5 Roquette

17 Seppic

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Sigachi Industries

2 The Dow Chemical Company

1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

40 Coating Systems & Additives

39 Topical

35 Solubilizers

27 Thickeners and Stabilizers

27 Parenteral

20 Emulsifying Agents

16 Controlled & Modified Release

14 Film Formers & Plasticizers

13 Surfactant & Foaming Agents

8 Fillers, Diluents & Binders

8 Direct Compression

7 Granulation

5 Empty Capsules

OINTMENT;TOPICAL - 400 UNITS/GM;1%;EQ 3.5MG BASE/GM;5,000 UNITS/GM Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

CREAM;TOPICAL - 0.5%;EQ 3.5MG BASE/GM;10,000 UNITS/GM Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

SOLUTION/DROPS;OPHTHALMIC - 10,000 UNITS/ML;EQ 1MG BASE/ML Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons