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    PENBUTOLOL SULFATE

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
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    2D Structure
    Also known as: Penbutolol sulfate, Betapressin, 38363-32-5, Penbutolol sulfate (200 mg), Hoe-893d, Hoe-39893d
    Molecular Formula
    C18H31NO6S
    Molecular Weight
    389.5  g/mol
    InChI Key
    KTXVDQNRHZQBOR-RSAXXLAASA-N
    A nonselective beta-blocker used as an antihypertensive and an antianginal agent.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol;sulfuric acid
    2.1.2 InChI
    InChI=1S/C18H29NO2.H2O4S/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14;1-5(2,3)4/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3;(H2,1,2,3,4)/t15-;/m0./s1
    2.1.3 InChI Key
    KTXVDQNRHZQBOR-RSAXXLAASA-N
    2.1.4 Canonical SMILES
    CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    CC(C)(C)NC[C@@H](COC1=CC=CC=C1C2CCCC2)O.OS(=O)(=O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Betapressin

    2. Hoe 893d

    3. Hoe-893d

    4. Hoe893d

    5. Penbutolol

    6. Penbutolol Sulfate

    7. Penbutolol Sulfate (2:1)

    8. Sulfate, Penbutolol

    2.2.2 Depositor-Supplied Synonyms

    1. Penbutolol Sulfate

    2. Betapressin

    3. 38363-32-5

    4. Penbutolol Sulfate (200 Mg)

    5. Hoe-893d

    6. Hoe-39893d

    7. Schembl41409

    8. Chembl1200363

    9. Pharmakon1600-01505567

    10. Nsc760043

    11. Ccg-213484

    12. 363p325

    2.3 Create Date
    2006-07-28
    3 Chemical and Physical Properties
    Molecular Weight 389.5 g/mol
    Molecular Formula C18H31NO6S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count7
    Exact Mass389.18720888 g/mol
    Monoisotopic Mass389.18720888 g/mol
    Topological Polar Surface Area125 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity375
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameLevatol
    PubMed HealthPenbutolol (By mouth)
    Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
    Drug Labellevatol (penbutolol sulfate) is a synthetic -receptor antagonist for oral administration. The chemical name of penbutolol sulfate is (S)-1-tert-butylamino-3-(o-cyclopentylphenoxy)-2-propanol sulfate. It is provided as the levorotatory isomer. The...
    Active IngredientPenbutolol sulfate
    Dosage FormTablet
    RouteOral
    Strength20mg
    Market StatusPrescription
    CompanyAuxilium Pharms

    2 of 2  
    Drug NameLevatol
    PubMed HealthPenbutolol (By mouth)
    Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
    Drug Labellevatol (penbutolol sulfate) is a synthetic -receptor antagonist for oral administration. The chemical name of penbutolol sulfate is (S)-1-tert-butylamino-3-(o-cyclopentylphenoxy)-2-propanol sulfate. It is provided as the levorotatory isomer. The...
    Active IngredientPenbutolol sulfate
    Dosage FormTablet
    RouteOral
    Strength20mg
    Market StatusPrescription
    CompanyAuxilium Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic beta-Antagonists

    Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)