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    Technical details about NCGC00024951-02, learn more about the structure, uses, toxicity, action, side effects and more

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    NCGC00024951-02

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

    MARKET PLACE

    ANALYTICAL SOLUTION(s)

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    2D Structure
    Also known as: 3605-01-4, Trivastal, Trivastan, 2-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine, Et-495, Eu-4200
    Molecular Formula
    C16H18N4O2
    Molecular Weight
    298.34  g/mol
    InChI Key
    OQDPVLVUJFGPGQ-UHFFFAOYSA-N
    FDA UNII
    DO22K1PRDJ
    A dopamine D2 agonist. It is used in the treatment of parkinson disease, particularly for alleviation of tremor. It has also been used for circulatory disorders and in other applications as a D2 agonist.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
    2.1.2 InChI
    InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2
    2.1.3 InChI Key
    OQDPVLVUJFGPGQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC=CC=N4
    2.2 Other Identifiers
    2.2.1 UNII
    DO22K1PRDJ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Et 495

    2. Et-495

    3. Et495

    4. Eu 4200

    5. Eu-4200

    6. Eu4200

    7. Hydrochloride, Piribedil

    8. Mesylate, Piribedil

    9. Mono-hydrochloride, Piribedil

    10. Piribedil Hydrochloride

    11. Piribedil Mesylate

    12. Piribedil Mono Hydrochloride

    13. Piribedil Mono-hydrochloride

    14. Piribendyl

    15. Trivastal

    2.3.2 Depositor-Supplied Synonyms

    1. 3605-01-4

    2. Trivastal

    3. Trivastan

    4. 2-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine

    5. Et-495

    6. Eu-4200

    7. Et 495

    8. 2-(4-piperonyl-1-piperazinyl)pyrimidine

    9. 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

    10. Eu 4200

    11. Do22k1prdj

    12. 1-(2-pyrimidyl)-4-piperonylpiperazine

    13. Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-

    14. Pyrimidine, 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-

    15. Piribedil (inn)

    16. 2-(4-(3,4-methylenedioxybenzyl)piperazino)pyrimidine

    17. 1-(3,4-methylenedioxybenzyl)-4-(2-pyrimidyl)piperazine

    18. Ncgc00015857-05

    19. 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)pyrimidine

    20. 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine

    21. Piribedil [inn]

    22. Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-

    23. Dsstox_cid_25188

    24. Dsstox_rid_80735

    25. Dsstox_gsid_45188

    26. 2-[4-(2h-1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

    27. Cas-3605-01-4

    28. Piribedile [dcit]

    29. Piribedil [inn:dcf]

    30. Piribedilum [inn-latin]

    31. Piribedile

    32. Piribedilum

    33. Sr-01000076091

    34. Trivastal (tn)

    35. Einecs 222-764-6

    36. Brn 0963637

    37. Tocris-1031

    38. Piribedil [mi]

    39. Prestwick0_000980

    40. Prestwick1_000980

    41. Prestwick2_000980

    42. Prestwick3_000980

    43. Unii-do22k1prdj

    44. Lopac-p-9233

    45. Biomol-nt_000044

    46. Gtpl49

    47. Piribedil [mart.]

    48. Cambridge Id 5268291

    49. Piribedil [who-dd]

    50. Lopac0_000965

    51. Oprea1_061309

    52. Oprea1_215383

    53. Bspbio_001019

    54. Schembl150101

    55. Spbio_002930

    56. Bpbio1_001121

    57. Bpbio1_001269

    58. Chembl1371770

    59. Dtxsid9045188

    60. Bdbm85092

    61. Chebi:92833

    62. 2-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine

    63. Hms2089m17

    64. Hms3885e19

    65. Bcp10553

    66. Nsc_4850

    67. Tox21_110245

    68. Mfcd00868264

    69. S3656

    70. Stl497889

    71. Zinc19537374

    72. Akos001309525

    73. Tox21_110245_1

    74. Ac-1051

    75. Ccg-205045

    76. Cs-8014

    77. Db12478

    78. Es-0016

    79. Sdccgsbi-0050938.p003

    80. Ncgc00015857-01

    81. Ncgc00015857-02

    82. Ncgc00015857-03

    83. Ncgc00015857-04

    84. Ncgc00015857-06

    85. Ncgc00015857-07

    86. Ncgc00015857-09

    87. Ncgc00015857-16

    88. Ncgc00024951-01

    89. Ncgc00024951-02

    90. Ncgc00024951-03

    91. Hy-12707

    92. Cas_3605-01-4

    93. Sbi-0050938.p002

    94. Cas-78213-63-5

    95. Ab00514645

    96. Ft-0610865

    97. P2054

    98. 2,5-diamino-4-(dimethylamino)-4-nitrostilbene

    99. D07305

    100. T72361

    101. Ab00514645-19

    102. 605p014

    103. A823101

    104. L000476

    105. Q413976

    106. Brd-k47936004-001-01-9

    107. Brd-k47936004-003-03-1

    108. Sr-01000076091-11

    109. Z31240640

    110. 1-(2-pyrimidyl)-4-(3,4-methylenedioxybenzyl)piperazine

    111. 2-{4-[(1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}pyrimidine

    112. 2-{4-[(2h-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}pyrimidine

    113. 2-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine Methanesulfonate

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 298.34 g/mol
    Molecular Formula C16H18N4O2
    XLogP31.8
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count3
    Exact Mass298.14297583 g/mol
    Monoisotopic Mass298.14297583 g/mol
    Topological Polar Surface Area50.7 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity356
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    Dopamine Agonists

    Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

    4.2 ATC Code

    N04BC08

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N04 - Anti-parkinson drugs

    N04B - Dopaminergic agents

    N04BC - Dopamine agonists

    N04BC08 - Piribedil

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