loader
Please Wait
Applying Filters...

Seqens Seqens

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about NCGC00024672-04, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    NCGC00024672-04

    APIs // Active Pharmaceutical Ingredients

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

    ANALYTICAL SOLUTION(s)

    DIGITAL CONTENT

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 57149-07-2, Flivas, Kt-611, Naftopidil [inn], Avishot, 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol
    Molecular Formula
    C24H28N2O3
    Molecular Weight
    392.5  g/mol
    InChI Key
    HRRBJVNMSRJFHQ-UHFFFAOYSA-N
    FDA UNII
    R9PHW59SFN
    Naftopidil has been investigated for the treatment of Disorder of Urinary Stent.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
    2.1.2 InChI
    InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
    2.1.3 InChI Key
    HRRBJVNMSRJFHQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
    2.2 Other Identifiers
    2.2.1 UNII
    R9PHW59SFN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol

    2.3.2 Depositor-Supplied Synonyms

    1. 57149-07-2

    2. Flivas

    3. Kt-611

    4. Naftopidil [inn]

    5. Avishot

    6. 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol

    7. Bm-15275

    8. Naftopidil (flivas)

    9. R9phw59sfn

    10. Nsc-759293

    11. Chembl142635

    12. Ncgc00015718-06

    13. 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol

    14. Dsstox_cid_25176

    15. Dsstox_rid_80725

    16. Dsstox_gsid_45176

    17. Naftopidilum [latin]

    18. Naftopidilum

    19. 4-(2-methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol

    20. Naftopidil Hydrochloride Hydrate

    21. Smr000466346

    22. Cas-57149-07-2

    23. Naftopidil (unspecified)

    24. Unii-r9phw59sfn

    25. Brn 0629965

    26. Naftopidil,(s)

    27. Flivas (tn)

    28. Naftopidil [mi]

    29. Naftopidil [jan]

    30. Prestwick0_000975

    31. Prestwick1_000975

    32. Prestwick2_000975

    33. Prestwick3_000975

    34. (+-)-1-(4-(2-methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol

    35. Naftopidil (jp17/inn)

    36. (rs)-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol

    37. 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol

    38. Cid_4418

    39. Naftopidil [mart.]

    40. Naftopidil [who-dd]

    41. Lopac0_000941

    42. Regid_for_cid_4418

    43. Bspbio_001009

    44. Mls000759459

    45. Mls001424117

    46. Schembl113215

    47. Spbio_002920

    48. Bpbio1_001111

    49. Dtxsid5045176

    50. Bdbm50773

    51. Chebi:31891

    52. Cid_6603044

    53. Hms2051b09

    54. Hms2089g07

    55. Hms3393b09

    56. Hms3655h21

    57. Hms3884p07

    58. Pharmakon1600-01506024

    59. Bcp21786

    60. Hy-b0391

    61. 3-(naphthalen-1-yloxy)propan-2-ol

    62. Tox21_110205

    63. Bbl028454

    64. Mfcd00242741

    65. Nsc759293

    66. S2126

    67. Stl372645

    68. (+-)-4-(o-methoxyphenyl)-alpha-((1-naphthyloxy)methyl)-1-piperazineethanol

    69. 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol

    70. 1-pioerazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-

    71. Akos002279617

    72. Akos016328058

    73. Tox21_110205_1

    74. Bcp9000976

    75. Ccg-100935

    76. Ccg-205022

    77. Db12092

    78. Fe-0209

    79. Nc00185

    80. Nsc 759293

    81. Sb19321

    82. Sdccgsbi-0050915.p003

    83. Ncgc00015718-04

    84. Ncgc00015718-05

    85. Ncgc00015718-08

    86. Ncgc00015718-09

    87. Ncgc00015718-10

    88. Ncgc00015718-12

    89. Ncgc00015718-25

    90. Ncgc00024672-03

    91. Ncgc00024672-04

    92. Bn164631

    93. 1-(4-(2-methoxyphenyl)piperazin-1-yl)-

    94. Sbi-0050915.p002

    95. Ab00514643

    96. Ft-0630696

    97. N0832

    98. Sw196570-4

    99. 49n072

    100. D01674

    101. Ab00489961-18

    102. Ab00489961-19

    103. Ab00489961_20

    104. Ab00489961_21

    105. A831328

    106. Q6958243

    107. Brd-a01787639-300-03-7

    108. Brd-a01787639-300-04-5

    109. 1-[4-(2-methoxyphenyl)piperazinyl]-3-(1-naphthyloxy)propan-2-ol

    110. 1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol

    111. 1-[4-(2-methoxyphenyl)piperazino]-3-(1-naphthoxy)propan-2-ol;hydrochloride

    112. Bm-15275; Kt-611; Bm 15275; Kt 611; Bm15275; Kt611

    113. (+/-)-4-(o-methoxyphenyl)-.alpha.-((1-naphthyloxy)methyl)-1-piperazineethanol

    114. 1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol;hydrochloride

    115. 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol;hydrochloride

    116. 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;hydrochloride

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 392.5 g/mol
    Molecular Formula C24H28N2O3
    XLogP34.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count7
    Exact Mass392.20999276 g/mol
    Monoisotopic Mass392.20999276 g/mol
    Topological Polar Surface Area45.2 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity483
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Adrenergic alpha-Antagonists

    Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)

    Calcium Channel Blockers

    A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

    Platelet Aggregation Inhibitors

    Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

    Post Enquiry
    POST ENQUIRY