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    Nalorphine Hydrochloride

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    2D Structure
    Also known as: Nalorphine hcl, 57-29-4, 9fpe56z2tw, Nalorphine hydrochloride ciii, Nalorphine hydrochloride [usp], Dea no. 9400
    Molecular Formula
    C19H22ClNO3
    Molecular Weight
    347.8  g/mol
    InChI Key
    NAHATSPWSULUAA-ZQGPYOJVSA-N
    FDA UNII
    9FPE56Z2TW
    A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12-,13+,15-,18-,19-;/m0./s1
    2.1.3 InChI Key
    NAHATSPWSULUAA-ZQGPYOJVSA-N
    2.1.4 Canonical SMILES
    C=CCN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.Cl
    2.1.5 Isomeric SMILES
    C=CCN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    9FPE56Z2TW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Allylnormorphine

    2. Hydrobromide, Nalorphine

    3. Hydrochloride, Nalorphine

    4. Lethidrone

    5. Nalorphine

    6. Nalorphine Hydrobromide

    7. Nalorphine, (14 Alpha)-isomer

    8. Nalorphine, L-tartrate (1:1)

    2.3.2 Depositor-Supplied Synonyms

    1. Nalorphine Hcl

    2. 57-29-4

    3. 9fpe56z2tw

    4. Nalorphine Hydrochloride Ciii

    5. Nalorphine Hydrochloride [usp]

    6. Dea No. 9400

    7. Miromorfalil

    8. (4r,4ar,7s,7ar,12bs)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;hydrochloride

    9. Nalorphine Hydrochloride (usp)

    10. N-allylnormorphine Hydrochloride

    11. Allylmorphine Hydrochloride

    12. Ncgc00168255-01

    13. Einecs 200-321-8

    14. Normorphine, N-allyl-, Hydrochloride

    15. Unii-9fpe56z2tw

    16. N-allyl-2,12-dihydroxy-1,11-epoxymorphinene-13 Hydrochloride

    17. 17-allyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol Hydrochloride

    18. Dsstox_cid_27825

    19. Dsstox_rid_82588

    20. Nalline [veterinary] (tn)

    21. Dsstox_gsid_47847

    22. Cloridrato De Nalorfina (tn)

    23. Schembl149571

    24. Chembl1908349

    25. Dtxsid3047847

    26. Tox21_112614

    27. Nalorphine Hydrochloride [mi]

    28. Cas-57-29-4

    29. Morphinan-3,6-alpha-diol, 17-allyl-7,8-didehydro-4,5-alpha-epoxy-, Hydrochloride

    30. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(2-propenyl)-(5alpha,6alpha)-, Hydrochloride

    31. Nalorphine Hydrochloride [mart.]

    32. Nalorphine Hydrochloride [who-dd]

    33. Nalorphinehydrochlorideciii(250mg)

    34. Nalorphine Hydrochloride [green Book]

    35. Nalorphine Hydrochloride Ciii [usp-rs]

    36. D08248

    37. Nalorphine Hydrochloride [usp Monograph]

    38. Q27272499

    39. Nalorphine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    40. 17-allyl-7,8-didehydro-4,5.alpha.-epoxymorphinan-3,6.alpha.-diol Hydrochloride

    41. Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(2-propenyl)-(5.alpha.,6.alpha.)-, Hydrochloride

    42. Nalorphine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 347.8 g/mol
    Molecular Formula C19H22ClNO3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count2
    Exact Mass347.1288213 g/mol
    Monoisotopic Mass347.1288213 g/mol
    Topological Polar Surface Area52.9 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity549
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Narcotic Antagonists

    Agents inhibiting the effect of narcotics on the central nervous system. (See all compounds classified as Narcotic Antagonists.)