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Technical details about MolPort-002-221-851, learn more about the structure, uses, toxicity, action, side effects and more

MolPort-002-221-851

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

9 Suppliers, 7 USDMF, 1 EU WC, 1 NDC API, 2 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Forms

49 Dossiers, 33 FDA Orange Book, 3 Canada, 13 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 29 Kerry, 23 BASF, 16 Roquette, 11 Microlex e.U, 10 Sigachi Industries, 10 Corel Pharma Chem, 8 Gangwal Healthcare, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 7 Gangwal Chemicals, 7 Seppic, 6 Lonza Capsugel, 5 Ideal Cures Pvt Ltd, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 5 DFE Pharma, 4 SPI Pharma, 3 Ingredion Pharma Solutions, 3 Kima Chemical, 3 Prachin Chemical, 3 Vasa Pharmachem, 3 Actylis, 2 Seqens, 2 The Dow Chemical Company, 2 Pharmatrans-Sanaq, 2 Nomisma Healthcare, 1 Finar, 1 Nanjing Well Pharmaceutical, 1 Jai Radhe Sales, 1 Ulanqab Kema New Material, 1 ACG Worldwide, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 1 Boai NKY Pharmaceuticals Ltd

EXCIPIENTS BY APPLICATIONS

56 Fillers, Diluents & Binders, 44 Coating Systems & Additives, 28 Controlled & Modified Release, 26 Direct Compression, 21 Disintegrants & Superdisintegrants, 21 Granulation, 17 Thickeners and Stabilizers, 12 Solubilizers, 12 Lubricants & Glidants, 10 Co-Processed Excipients, 9 Film Formers & Plasticizers, 9 Taste Masking, 8 Topical, 6 Chewable & Orodispersible Aids, 5 Empty Capsules, 5 Parenteral, 4 Vegetarian Capsules, 4 API Stability Enhancers, 3 Emulsifying Agents, 3 Rheology Modifiers, 2 Coloring Agents

GLOBAL SALES INFORMATION

8 US Medicaid Prescriptions, 4 Finished Drug Prices

MARKET PLACE

4 APIs

4 APIs

ANALYTICAL SOLUTION(s)

1 USP Standards, 1 Other Ref. Standards

Also known as: Cpd000059133, Mls000069471, Fluoperazine, Calmazine, Smr000059133, Stalazine hydrochloride

Molecular Formula

C₂₁H₂₅ClF₃N₃S

Molecular Weight

444.0 g/mol

InChI Key

RIULCFSTKRDHBX-UHFFFAOYSA-N

A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride

2.1.2 InChI

InChI=1S/C21H24F3N3S.ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;/h2-3,5-8,15H,4,9-14H2,1H3;1H

2.1.3 InChI Key

RIULCFSTKRDHBX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Apo Trifluoperazine

2. Apo-trifluoperazine

3. Apotrifluoperazine

4. Flupazine

5. Stelazine

6. Terfluzine

7. Trifluoperazine

8. Trifluoperazine Hcl

9. Trifluoperazine Hydrochloride

10. Trifluoroperazine

11. Trifluperazine

12. Triftazin

2.2.2 Depositor-Supplied Synonyms

1. Cpd000059133

2. Mls000069471

3. Fluoperazine

4. Calmazine

5. Smr000059133

6. Stalazine Hydrochloride

7. 10h-phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, Hydrochloride (1:2)

8. Stelazine Dihydrochloride

9. Trifluperazine Dihydrochloride

10. Mls001146870

11. Mls002702821

12. Trifluoroperazine Dihydrochloride

13. 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride

14. 10-[3-(4-methylpiperazinyl)propyl]-2-(trifluoromethyl)phenothiazine, Chloride, Chloride

15. Nsc17474

16. Skf 5019

17. Eskazine Dihydrochloride

18. Triflurin Dihydrochloride

19. Opera_id_1296

20. Trifluoperazine Hydrochoride

21. Chembl1710

22. Schembl41194

23. Tripfluoperazine Hydrochloride

24. Mls000758242

25. Mls001423986

26. Mls002222216

27. Triflorperazine Dihydrochloride

28. Trifluoropyrazin Dihydrochloride

29. Pharmakon1600-01500591

30. Nsc757369

31. Akos016395836

32. Ccg-100803

33. Nc00053

34. Ncgc00180883-01

35. Ncgc00180883-02

36. Wln: T C666 Bn Isj Exfff B3- At6n Dntj D1 &gh 2

2.3 Create Date

2005-07-29

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₅ClF₃N₃S
Molecular Weight	444.0 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	443.1409812 g/mol
Monoisotopic Mass	443.1409812 g/mol
Topological Polar Surface Area	35 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	510
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

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