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    Technical details about MolPort-002-070-488, learn more about the structure, uses, toxicity, action, side effects and more

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    MolPort-002-070-488

    DOSSIERs // Finished Dosage Forms

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 526-08-9, Sulphaphenazole, Sulfabid, 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)benzenesulfonamide, Plisulfan, Raziosulfa
    Molecular Formula
    C15H14N4O2S
    Molecular Weight
    314.4  g/mol
    InChI Key
    QWCJHSGMANYXCW-UHFFFAOYSA-N
    FDA UNII
    0J8L4V3F81
    A sulfonilamide anti-infective agent.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide
    2.1.2 InChI
    InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
    2.1.3 InChI Key
    QWCJHSGMANYXCW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)N
    2.2 Other Identifiers
    2.2.1 UNII
    0J8L4V3F81
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Phenylsulfapyrazole

    2. Sulfaphenylpyrazol

    3. Sulphaphenazole

    2.3.2 Depositor-Supplied Synonyms

    1. 526-08-9

    2. Sulphaphenazole

    3. Sulfabid

    4. 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)benzenesulfonamide

    5. Plisulfan

    6. Raziosulfa

    7. Sulfafenazol

    8. Sulfaphenazol

    9. Sulfaphenazon

    10. Depocid

    11. Depotsulfonamide

    12. Sulphenazole

    13. Sulfaphenylpyrazole

    14. Sulfaphenylpipazol

    15. Sulfaphenazolum

    16. Merian

    17. Sulfafenazolo

    18. Eftolon

    19. Firmazolo

    20. Paidazolo

    21. Inamil

    22. Isarol

    23. Orisul

    24. 1-phenyl-5-sulfanilamidopyrazole

    25. 5-sulfanilamido-1-phenylpyrazole

    26. Microtan Pirazolo

    27. N'-(1-phenylpyrazol-5-yl)sulfanilamide

    28. Sulfafenazolo [italian]

    29. 3-(p-aminobenzenesulfonamido)-2-phenylpyrazole

    30. Sulfafenazol [inn-spanish]

    31. Sulfaphenazol [inn-french]

    32. Sulfaphenazolum [inn-latin]

    33. Benzenesulfonamide, 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)-

    34. 4-amino-n-(2-phenylpyrazol-3-yl)benzenesulfonamide

    35. N1-(1-phenylpyrazol-5-yl)sulfanilamide

    36. N(sup 1)-(1-phenylpyrazol-5-yl)sulfanilamide

    37. 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)benzene-1-sulfonamide

    38. Nsc-757859

    39. Chembl1109

    40. N(1)-(1-phenylpyrazol-5-yl)sulfanilamide

    41. Chebi:77780

    42. 0j8l4v3f81

    43. Sulfaphenylpyrazol

    44. Phenylsulfapyrazole

    45. Ncgc00015925-02

    46. Solfafenazolo

    47. Cas-526-08-9

    48. Solfafenazolo [dcit]

    49. Dsstox_cid_24131

    50. Dsstox_rid_80106

    51. Dsstox_gsid_44131

    52. Orisulf

    53. Isarol V

    54. Smr000326684

    55. Prestwick_454

    56. Unii-0j8l4v3f81

    57. Sr-01000075649

    58. Einecs 208-384-3

    59. Lopac-s-0758

    60. Sulfaphenazole (jan/inn)

    61. Brn 0308518

    62. Sulfonylpyrazol

    63. Sulfaphenazole [inn:ban:jan]

    64. Sulfabid (tn)

    65. Sulfanilamide, N(sup 1)-(1-phenylpyrazol-5-yl)-

    66. Mfcd00057226

    67. Spectrum_001406

    68. Prestwick0_000021

    69. Prestwick1_000021

    70. Prestwick2_000021

    71. Prestwick3_000021

    72. Spectrum2_001943

    73. Spectrum3_001741

    74. Spectrum4_000443

    75. Spectrum5_001185

    76. Sulfaphenazole, >=98%

    77. Sulfanilamide, N1-(1-phenylpyrazol-5-yl)-

    78. Sulfaphenazole [mi]

    79. Sulfaphenazole [inn]

    80. Sulfaphenazole [jan]

    81. Lopac0_001095

    82. Bspbio_000081

    83. Bspbio_003442

    84. Kbiogr_000826

    85. Kbioss_001886

    86. 5-25-09-00415 (beilstein Handbook Reference)

    87. Mls000859612

    88. Mls001056713

    89. Divk1c_000303

    90. Schembl122040

    91. Spectrum1501143

    92. Spbio_002002

    93. Spbio_002005

    94. Sulfaphenazole [mart.]

    95. Bpbio1_000091

    96. Sulfaphenazole [who-dd]

    97. Dtxsid2044131

    98. Gtpl11352

    99. Hms500p05

    100. Kbio1_000303

    101. Kbio2_001886

    102. Kbio2_004454

    103. Kbio2_007022

    104. Kbio3_002662

    105. Zinc57490

    106. 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)-benzenesulfonamide

    107. 4-amino-n-(2-phenyl-2h-pyrazol-3-yl)-benzenesulfonamide

    108. Ninds_000303

    109. Hms1568e03

    110. Hms1921j13

    111. Hms2095e03

    112. Hms2235j21

    113. Hms3263k12

    114. Hms3373e16

    115. Hms3712e03

    116. Pharmakon1600-01501143

    117. Sulfaphenazole, >=98% (hplc)

    118. Albb-025160

    119. Bcp27626

    120. Hy-b1218

    121. Str05485

    122. Sulfaphenazole [orange Book]

    123. Tox21_110262

    124. Tox21_501095

    125. Bdbm50090677

    126. Ccg-39431

    127. Nsc757859

    128. Pyrazole, 1-phenyl-5-sulfanilamido-

    129. S3673

    130. Stk663863

    131. Akos003348743

    132. Tox21_110262_1

    133. Cs-4843

    134. Db06729

    135. Lp01095

    136. Nsc 757859

    137. Sdccgsbi-0051065.p004

    138. Idi1_000303

    139. Ncgc00015925-01

    140. Ncgc00015925-03

    141. Ncgc00015925-04

    142. Ncgc00015925-05

    143. Ncgc00015925-06

    144. Ncgc00015925-07

    145. Ncgc00015925-08

    146. Ncgc00015925-09

    147. Ncgc00015925-10

    148. Ncgc00015925-12

    149. Ncgc00015925-13

    150. Ncgc00015925-17

    151. Ncgc00094368-01

    152. Ncgc00094368-02

    153. Ncgc00094368-03

    154. Ncgc00094368-04

    155. Ncgc00094368-05

    156. Ncgc00261780-01

    157. Sulfaphenazole 100 Microg/ml In Methanol

    158. Sbi-0051065.p003

    159. Ab00052218

    160. Eu-0101095

    161. Ft-0761575

    162. Sulfaphenazole 100 Microg/ml In Acetonitrile

    163. Bim-0051065.0001

    164. D01954

    165. D70410

    166. S 0758

    167. Ab00052218_10

    168. Q6577293

    169. Sr-01000075649-2

    170. Sr-01000075649-7

    171. Sr-01000075649-8

    172. Sr-01000075649-9

    173. Brd-k10671814-001-05-6

    174. Brd-k10671814-001-09-8

    175. 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)-1-benzenesulfonamide

    176. Brn-0308518; Brn0308518; Brn 0308518;sulfabid;sulfaphenylpyrazol;sulphaphenazole

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 314.4 g/mol
    Molecular Formula C15H14N4O2S
    XLogP31.5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count4
    Exact Mass314.08374688 g/mol
    Monoisotopic Mass314.08374688 g/mol
    Topological Polar Surface Area98.4 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity451
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For the treatment bacterial infections.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Infective Agents

    Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)

    5.2 ATC Code

    J - Antiinfectives for systemic use

    J01 - Antibacterials for systemic use

    J01E - Sulfonamides and trimethoprim

    J01ED - Long-acting sulfonamides

    J01ED08 - Sulfaphenazole

    S - Sensory organs

    S01 - Ophthalmologicals

    S01A - Antiinfectives

    S01AB - Sulfonamides

    S01AB05 - Sulfafenazol

    5.3 Metabolism/Metabolites

    Hepatic.

    5.4 Mechanism of Action

    Sulfaphenazole is a sulfonamide antibacterial. In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthetase (DHPS), an enzyme involved in folate synthesis. As such, the microorganism will be "starved" of folate and die.

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