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    Technical details about MolPort-001-734-403, learn more about the structure, uses, toxicity, action, side effects and more

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    MolPort-001-734-403

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 57132-53-3, Proglumetacina, Proglumetacine, Proglumetacinum, 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate, Chebi:76263
    Molecular Formula
    C46H58ClN5O8
    Molecular Weight
    844.4  g/mol
    InChI Key
    PTXGHCGBYMQQIG-UHFFFAOYSA-N
    FDA UNII
    FV919079LU
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate
    2.1.2 InChI
    InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)
    2.1.3 InChI Key
    PTXGHCGBYMQQIG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CC1)CCOC(=O)CC2=C(N(C3=C2C=C(C=C3)OC)C(=O)C4=CC=C(C=C4)Cl)C)NC(=O)C5=CC=CC=C5
    2.2 Other Identifiers
    2.2.1 UNII
    FV919079LU
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3'-(4-(2-(1-p-chlorobenzoyl-5-methoxy-2-methylindol-3-ylacetoxy)ethyl)piperazin-1-yl)propyl-4-benzamido-n,n-dipropylglutaramate (+-) Dimaleate

    2. Prodamox

    3. Proglumetacin Dimaleate

    4. Proglumetacin Maleate

    5. Protacine

    6. Protaxil

    7. Protaxon

    2.3.2 Depositor-Supplied Synonyms

    1. 57132-53-3

    2. Proglumetacina

    3. Proglumetacine

    4. Proglumetacinum

    5. 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate

    6. Chebi:76263

    7. Fv919079lu

    8. Proglumetacin (inn)

    9. Ncgc00183024-01

    10. Proglumetacin [inn]

    11. 3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl Dl-4-benzamido-n,n-dipropylglutaramate 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate (ester)

    12. Proglumetacin [inn:ban]

    13. Proglumetacine [inn-french]

    14. Proglumetacinum [inn-latin]

    15. Proglumetacina [inn-spanish]

    16. Unii-fv919079lu

    17. Bruxel (tn)

    18. Proglumetacin [mi]

    19. Dsstox_cid_28768

    20. Dsstox_rid_83037

    21. Dsstox_gsid_48842

    22. Schembl27106

    23. Proglumetacin [who-dd]

    24. Chembl2105825

    25. Dtxsid0048842

    26. Tox21_113325

    27. Db13527

    28. Cas-57132-53-3

    29. Hy-106560

    30. Cs-0026053

    31. Ft-0758237

    32. D08427

    33. A913226

    34. Q2208070

    35. 5-(dipropylamino)-1,5-dioxopentyl)oxy)propyl)-1-piperazinyl)ethyl Ester, (+/-)-

    36. 1h-indole-3-acetic Acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-(4-(3-((4-(benzoylamino)-

    37. 1h-indole-3-acetic Acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-(4-(3-((4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl)oxy)propyl)-1-piperazinyl)ethyl Ester

    38. 1h-indole-3-acetic Acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-[4-[3-[[4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl]oxy]propyl]-1-piperazinyl]ethyl Ester (9ci)

    39. 3-(4-(2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indol-3-yl)acetoxy)ethyl)piperazin-1-yl)propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate

    40. 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-n,n-dipropyl-alpha-glutaminate

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 844.4 g/mol
    Molecular Formula C46H58ClN5O8
    XLogP37.3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count23
    Exact Mass843.3973915 g/mol
    Monoisotopic Mass843.3973915 g/mol
    Topological Polar Surface Area140 Ų
    Heavy Atom Count60
    Formal Charge0
    Complexity1360
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    4.2 ATC Code

    M - Musculo-skeletal system

    M01 - Antiinflammatory and antirheumatic products

    M01A - Antiinflammatory and antirheumatic products, non-steroids

    M01AB - Acetic acid derivatives and related substances

    M01AB14 - Proglumetacin

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