loader
Please Wait
Applying Filters...

Seqens Seqens

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about MolPort-000-917-569, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    MolPort-000-917-569

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    MARKET PLACE

    ANALYTICAL SOLUTION(s)

    DIGITAL CONTENT

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 33125-97-2, Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate, Ethnor, Absele, 15301-65-2, C14h16n2o2
    Molecular Formula
    C14H16N2O2
    Molecular Weight
    244.29  g/mol
    InChI Key
    NPUKDXXFDDZOKR-UHFFFAOYSA-N
    Etomidate is an imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    ethyl 3-(1-phenylethyl)imidazole-4-carboxylate
    2.1.2 InChI
    InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3
    2.1.3 InChI Key
    NPUKDXXFDDZOKR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Absele

    2. Ethnor

    2.2.2 Depositor-Supplied Synonyms

    1. 33125-97-2

    2. Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

    3. Ethnor

    4. Absele

    5. 15301-65-2

    6. C14h16n2o2

    7. Radenarcon

    8. Amidate (pharmaceutical)

    9. Mls000034952

    10. 1h-imidazole-5-carboxylic Acid, 1-(1-phenylethyl)-, Ethyl Ester, (r)-

    11. Smr000010931

    12. Dsstox_cid_3033

    13. 1h-imidazole-5-carboxylic Acid, 1-(1-phenylethyl)-, Ethyl Ester, (+-)-

    14. Dsstox_rid_76841

    15. Dsstox_gsid_23033

    16. 1-(1-phenylethyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

    17. Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate

    18. Sr-01000325781

    19. Rac-etomidate

    20. Ncgc00016817-01

    21. Cas-33125-97-2

    22. Cpd000010931

    23. Opera_id_1830

    24. Prestwick0_001041

    25. Prestwick1_001041

    26. Prestwick2_001041

    27. (+)-ethyl 1-(.alpha.-methylbenzyl)imidazole-5-carboxylate

    28. Schembl39485

    29. Mls001240191

    30. Mls006011948

    31. Chembl23731

    32. Spbio_002901

    33. Chebi:91759

    34. Imidazole-5-carboxylic Acid, 1-(.alpha.-methylbenzyl)-, Ethyl Ester, (r)-(+)-

    35. Bdbm238149

    36. Dtxsid101347652

    37. Hms1571a04

    38. Hms1612g10

    39. Hms2093p17

    40. Hms2235k14

    41. Hms3259f15

    42. Hms3369p19

    43. Hms3371k15

    44. Hms3393p18

    45. Hms3428l14

    46. Hms3654n15

    47. Pharmakon1600-01505599

    48. Bcp21365

    49. Us9394290, Eto (etomidate)

    50. Tox21_110628

    51. Nsc759160

    52. S1329

    53. Akos000548952

    54. Akos021628930

    55. Tox21_110628_1

    56. Ac-5898

    57. Ccg-266910

    58. Nc00657

    59. Ncgc00025176-02

    60. Ncgc00036076-03

    61. Ds-14867

    62. Sbi-0206822.p001

    63. Db-015827

    64. Cs-0081287

    65. Ft-0630568

    66. Sw197275-2

    67. En300-50290

    68. Ab00439988-11

    69. Ab00439988_13

    70. Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate.

    71. A821630

    72. Ethyl1-(1-phenylethyl)-1h-imidazole-5-carboxylate

    73. Sr-01000325781-1

    74. Sr-01000325781-3

    75. Sr-01000325781-5

    76. Brd-a54880345-001-11-8

    77. Q27163565

    78. 3-(1-phenylethyl)-4-imidazolecarboxylic Acid Ethyl Ester

    79. Z802671476

    80. (-)-ethyl 1-(1-phenylethyl)-1h-imidazole- 5-carboxylate

    81. (-)-ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

    82. Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate, (+)-

    83. R-(+) Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

    84. 1-(.alpha.-methylbenzyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

    85. (r)-(+)-1-(.alpha.-methylbenzyl)imidazole-5-carboxylic Acid Ethyl Ester

    86. [r,(+)]-1-(alpha-methylbenzyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

    87. 1h-imidazole-5-carboxylic Acid, 1-(.alpha.-methylbenzyl)-, Ethyl Ester, (+)-

    88. R 16659 Pound>>r-16659 Pound>>r16659 Pound>>r 26490 Pound>>r-26490 Pound>>r26490

    2.3 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 244.29 g/mol
    Molecular Formula C14H16N2O2
    XLogP33
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count5
    Exact Mass244.121177757 g/mol
    Monoisotopic Mass244.121177757 g/mol
    Topological Polar Surface Area44.1 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity277
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAmidate
    Drug LabelAmidate (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The...
    Active IngredientEtomidate
    Dosage FormInjectable
    RouteInjection
    Strength2mg/ml
    Market StatusPrescription
    CompanyHospira

    2 of 4  
    Drug NameEtomidate
    Drug LabelEtomidate Injection, USP is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The drug etom...
    Active IngredientEtomidate
    Dosage FormInjectable
    RouteInjection
    Strength2mg/ml
    Market StatusPrescription
    CompanyPar Sterile Products; Bedford; Emcure Pharms; Luitpold; Zydus Pharms Usa; Agila Speclts

    3 of 4  
    Drug NameAmidate
    Drug LabelAmidate (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The...
    Active IngredientEtomidate
    Dosage FormInjectable
    RouteInjection
    Strength2mg/ml
    Market StatusPrescription
    CompanyHospira

    4 of 4  
    Drug NameEtomidate
    Drug LabelEtomidate Injection, USP is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The drug etom...
    Active IngredientEtomidate
    Dosage FormInjectable
    RouteInjection
    Strength2mg/ml
    Market StatusPrescription
    CompanyPar Sterile Products; Bedford; Emcure Pharms; Luitpold; Zydus Pharms Usa; Agila Speclts

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    General Anesthetic [EPC]; General Anesthesia [PE]
    5.2 ATC Code

    N01AX07

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N01 - Anesthetics

    N01A - Anesthetics, general

    N01AX - Other general anesthetics

    N01AX07 - Etomidate

    Post Enquiry
    POST ENQUIRY