loader
Please Wait
Applying Filters...

Evonik Evonik

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about Milrinone Lactate, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    Milrinone Lactate

    DEVELOPMENTS

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    DIGITAL CONTENT

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    Temad- We think of world-class quality.

    2D Structure
    1. Also known as: 100286-97-3, 9k8xr81mo8, 6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile lactate, 2-hydroxypropanoic acid;6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile, Chebi:34850, Unii-9k8xr81mo8
    Molecular Formula
    C15H15N3O4
    Molecular Weight
    301.30  g/mol
    InChI Key
    VWUPWEAFIOQCGF-UHFFFAOYSA-N
    FDA UNII
    9K8XR81MO8
    A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-hydroxypropanoic acid;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
    2.1.2 InChI
    InChI=1S/C12H9N3O.C3H6O3/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8;1-2(4)3(5)6/h2-6H,1H3,(H,15,16);2,4H,1H3,(H,5,6)
    2.1.3 InChI Key
    VWUPWEAFIOQCGF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2.CC(C(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    9K8XR81MO8
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Corotrop

    2. Corotrope

    3. Lactate, Milrinone

    4. Milrinone

    5. Primacor

    6. Win 47203

    7. Win-47203

    8. Win47203

    2.3.2 Depositor-Supplied Synonyms

    1. 100286-97-3

    2. 9k8xr81mo8

    3. 6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile Lactate

    4. 2-hydroxypropanoic Acid;6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile

    5. Chebi:34850

    6. Unii-9k8xr81mo8

    7. Milrinonelactate

    8. Milrinone Lactose In 5% Dextrose

    9. Primacor (tn)

    10. Primacor In Dextrose 5% In Plastic Container

    11. Milrinone Lactate [mi]

    12. Milrinone Lactate In 5% Dextrose In Plastic Container

    13. Chembl1200977

    14. Milrinone Lactate [vandf]

    15. Milrinone Lactate [mart.]

    16. Milrinone Lactate In Dextrose 5% In Plastic Container

    17. Milrinone Lactate [who-dd]

    18. Akos015917733

    19. Milrinone Lactate [orange Book]

    20. 1,6-dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile, Compd. With 2-hydroxypropionic Acid

    21. Ls-14389

    22. Ft-0739660

    23. D02085

    24. 286m973

    25. A897507

    26. Q27116295

    27. 2-[(4-chlorobenzyl)sulfanyl]benzenecarboxylicacid

    28. 1,6-dihydro-2-methyl-6-oxo[3,4'-bipyridine]-5-carbonitrile Lactate

    29. 2-hydroxypropanoic Acid,6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile

    30. 6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile 2-hydroxypropanoic Acid

    31. Hydron;2-hydroxypropanoate;6-methyl-2-oxo-5-pyridin-4-yl-1h-pyridine-3-carbonitrile

    32. Propanoic Acid, 2-hydroxy-, Compd. With 1,6-dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 301.30 g/mol
    Molecular Formula C15H15N3O4
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count2
    Exact Mass301.10625597 g/mol
    Monoisotopic Mass301.10625597 g/mol
    Topological Polar Surface Area123 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity478
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMilrinone lactate
    Drug LabelMilrinone Lactate Injection is a member of a new class of bipyridine inotropic/vasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Milrinone lactate is designated chemically as 1,6-Dihyd...
    Active IngredientMilrinone lactate
    Dosage FormInjectable
    Routeinjection; Injection
    Strength20mg/20ml; eq 1mg base/ml; eq 20mg /20ml (1mg/ml); eq 50mg /50ml (1mg/ml)
    Market StatusPrescription
    CompanyBedford; Hospira; Gland Pharma; Apotex; Hikma Farmaceutica; Fresenius Kabi Usa; Hikma Maple; Intl Medicated

    2 of 2  
    Drug NameMilrinone lactate
    Drug LabelMilrinone Lactate Injection is a member of a new class of bipyridine inotropic/vasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Milrinone lactate is designated chemically as 1,6-Dihyd...
    Active IngredientMilrinone lactate
    Dosage FormInjectable
    Routeinjection; Injection
    Strength20mg/20ml; eq 1mg base/ml; eq 20mg /20ml (1mg/ml); eq 50mg /50ml (1mg/ml)
    Market StatusPrescription
    CompanyBedford; Hospira; Gland Pharma; Apotex; Hikma Farmaceutica; Fresenius Kabi Usa; Hikma Maple; Intl Medicated

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Cardiotonic Agents

    Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

    Phosphodiesterase 3 Inhibitors

    Compounds that specifically inhibit PHOSPHODIESTERASE 3. (See all compounds classified as Phosphodiesterase 3 Inhibitors.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Platelet Aggregation Inhibitors

    Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phosphodiesterase 3 Inhibitors [MoA]; Phosphodiesterase 3 Inhibitor [EPC]
    Post Enquiry
    POST ENQUIRY