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Technical details about Milnacipran HCl, learn more about the structure, uses, toxicity, action, side effects and more

Milnacipran HCl

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

16 Suppliers, 10 USDMF, 4 EU WC, 6 NDC API, 12 Listed Suppliers

DOSSIERs // Finished Dosage Forms

25 Dossiers, 20 FDA Orange Book, 4 Canada, 1 Listed Dossiers

DRUG PRODUCT COMPOSITION

CAPSULE, EXTENDED RELEASE;ORAL - EQ 120MG BASE, CAPSULE, EXTENDED RELEASE;ORAL - EQ 20MG BASE, CAPSULE, EXTENDED RELEASE;ORAL - EQ 40MG BASE, CAPSULE, EXTENDED RELEASE;ORAL - EQ 80MG BASE

RELATED EXCIPIENT COMPANIES

Suppliers, 12 Kerry, 11 Corel Pharma Chem, 9 BASF, 7 Seppic, 6 Lonza Capsugel, 4 Kima Chemical, 4 Gangwal Chemicals, 4 Ideal Cures Pvt Ltd, 3 The Dow Chemical Company, 2 Roquette, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 Microlex e.U, 2 DKSH, 1 Qualicaps, 1 Aeon Procare, 1 Pfanstiehl, 1 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 1 Sigachi Industries, 1 Ulanqab Kema New Material, 1 Vertellus, 1 Gangwal Healthcare, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Actylis, 1 Boai NKY Pharmaceuticals Ltd, 1 Pharmatrans-Sanaq, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

EXCIPIENTS BY APPLICATIONS

46 Coating Systems & Additives, 24 Controlled & Modified Release, 14 Fillers, Diluents & Binders, 12 Film Formers & Plasticizers, 9 Granulation, 8 Solubilizers, 7 Taste Masking, 6 Direct Compression, 5 Empty Capsules, 4 Thickeners and Stabilizers, 4 Disintegrants & Superdisintegrants, 4 Vegetarian Capsules, 3 API Stability Enhancers, 2 Lubricants & Glidants, 2 Parenteral, 2 Coloring Agents, 1 Chewable & Orodispersible Aids, 1 Co-Processed Excipients, 1 Surfactant & Foaming Agents, 1 Emulsifying Agents, 1 Rheology Modifiers

GLOBAL SALES INFORMATION

14 US Medicaid Prescriptions, 4 Finished Drug Prices

MARKET PLACE

1 APIs

1 APIs

PATENTS

12 US Patents, 8 Health Canada Patents

DIGITAL CONTENT

1 Data Compilation & Company Tracker #PharmaFlow, 5 News

Milnacipran HCl
Chemistry
Full Screen View

Also known as: 175131-60-9, Milnacipran hydrochloride, (1s-cis)-milnacipran hydrochloride, Fetzima, F 2695 hydrochloride, 101152-94-7

Molecular Formula

C₁₅H₂₃ClN₂O

Molecular Weight

282.81 g/mol

InChI Key

XNCDYJFPRPDERF-NQQJLSKUSA-N

FDA UNII

371U2ZK31U

The (1S,2R)-isomer of milnacipran that is used for the treatment of MAJOR DEPRESSIVE DISORDER.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide;hydrochloride

2.1.2 InChI

InChI=1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m0./s1

2.1.3 InChI Key

XNCDYJFPRPDERF-NQQJLSKUSA-N

2.1.4 Canonical SMILES

CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl

2.1.5 Isomeric SMILES

CCN(CC)C(=O)[C@]1(C[C@H]1CN)C2=CC=CC=C2.Cl

2.2 Other Identifiers

2.2.1 UNII

371U2ZK31U

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Fetzima

2. Levomilnacipran

2.3.2 Depositor-Supplied Synonyms

1. 175131-60-9

2. Milnacipran Hydrochloride

3. (1s-cis)-milnacipran Hydrochloride

4. Fetzima

5. F 2695 Hydrochloride

6. 101152-94-7

7. Milnacipran ((1s-cis) Hydrochloride)

8. Milnacipran (1s-cis) Hydrochloride

9. Levomilnacipran Hcl

10. F2695 Hydrochloride

11. Levomilnacipran Hydrochloride [usan]

12. F-2695 Hydrochloride

13. 371u2zk31u

14. (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropane-1-carboxamide;hydrochloride

15. (1s-cis)-milnacipran Hcl

16. (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride

17. Levomilnacipran Hydrochloride (usan)

18. Cyclopropanecarboxamide, 2-(aminomethyl)-n,n-diethyl-1-phenyl-, Hydrochloride (1:1), (1s,2r)-

19. Midalcipran Hydrochloride

20. Rac-milnacipran Hydrochloride

21. Joncia

22. Unii-371u2zk31u

23. L-milnacipran Hcl

24. (1s,2r)-milnacipran Hydrochloride

25. Fetzima (tn)

26. Tn-912

27. Schembl1148742

28. Chembl2105732

29. Hy-b0168b

30. Milnacipran Hydrochloride Solution

31. Dtxsid801026201

32. Amy10333

33. Mfcd18433402

34. S5693

35. Akos025311514

36. Ccg-231710

37. Cs-4972

38. (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropane-1-carboxamide Hydrochloride

39. As-12868

40. M2133

41. Milnacipran Hydrochloride, (1s,2r)-

42. Levomilnacipran Hydrochloride [who-dd]

43. A14391

44. C13985

45. C73344

46. D10133

47. F-2207

48. 152m947

49. A899431

50. Levomilnacipran Hydrochloride [orange Book]

51. Q27256611

52. Milnacipran Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

2.4 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₃ClN₂O
Molecular Weight	282.81 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	282.1498911 g/mol
Monoisotopic Mass	282.1498911 g/mol
Topological Polar Surface Area	46.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	295
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Fetzima
PubMed Health	Levomilnacipran (By mouth)
Drug Classes	Antidepressant
Active Ingredient	Levomilnacipran hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	eq 40mg base; eq 80mg base; eq 120mg base; eq 20mg base
Market Status	Prescription
Company	Forest Labs

2 of 2
Drug Name	Fetzima
PubMed Health	Levomilnacipran (By mouth)
Drug Classes	Antidepressant
Active Ingredient	Levomilnacipran hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	eq 40mg base; eq 80mg base; eq 120mg base; eq 20mg base
Market Status	Prescription
Company	Forest Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antidepressive Agents

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. (See all compounds classified as Serotonin and Noradrenaline Reuptake Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin Uptake Inhibitors [MoA]; Serotonin and Norepinephrine Reuptake Inhibitor [EPC]; Norepinephrine Uptake Inhibitors [MoA]

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