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1. Bay F 1353
2. Bay-f 1353
3. Bayf 1353
4. Baypen
5. Melocin
6. Meslocillin
7. Mezlin
8. Mezlocillin Sodium
9. Mezlocilline
10. Sodium, Mezlocillin
1. 51481-65-3
2. Mezlin
3. Mezlocilina
4. Mezlocillinum
5. Mezlocilline
6. Mezlocillin Sodium
7. Mezlocillin Acid
8. Chebi:6919
9. Oh2o403d1g
10. (2s,5r,6r)-3,3-dimethyl-6-[[(2r)-2-[(3-methylsulfonyl-2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
11. (2s,5r,6r)-3,3-dimethyl-6-{[(2r)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
12. Multocillin
13. Bay-f-1353
14. 6beta-{(2r)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}penicillanic Acid
15. Ncgc00167470-01
16. (2s,5r,6r)-3,3-dimethyl-6-((r)-2-(3-(methylsulfonyl)-2-oxo-1-imidazolidinecarboxamido)-2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid
17. (2s,5r,6r)-3,3-dimethyl-6-((r)-2-(3-(methylsulfonyl)-2-oxoimidazolidine-1-carboxamido)-2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
18. Mezlocillin (usan/inn)
19. Mezlocilina [inn-spanish]
20. Mezlocilline [inn-french]
21. Mezlocillinum [inn-latin]
22. Unii-oh2o403d1g
23. Mezlocillin [usan:inn:ban]
24. 59798-30-0
25. Mezlocillin,(s)
26. Einecs 257-233-8
27. Mezlocillin [mi]
28. Mezlocillin [inn]
29. Dsstox_cid_3316
30. Mezlocillin [usan]
31. Epitope Id:120371
32. Mezlocillin [vandf]
33. Chembl1731
34. Dsstox_rid_76973
35. Mezlocillin [mart.]
36. Dsstox_gsid_23316
37. Schembl34075
38. Mezlocillin [who-dd]
39. Dtxsid1023316
40. Hy-b1466a
41. Zinc3831120
42. Tox21_112474
43. Db00948
44. (methylsulfonyl)-2-oxoimidazolidine-1-
45. Carboxamido)-2-phenylacetamido)-7-oxo-
46. Ncgc00167470-03
47. Ncgc00167470-05
48. 6beta-{(2r)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylic Acid
49. As-11668
50. Cas-51481-65-3
51. Cs-0013695
52. C07221
53. D05021
54. 481m653
55. A828617
56. (2s,5r,6r)-3,3-dimethyl-6-((r)-2-(3-
57. Q3307752
58. (2s,5r,6r)-3,3-dimethyl-6-[[(2r)-2-[(3-methylsulfonyl-2-oxidanylidene-imidazolidin-1-yl)carbonylamino]-2-phenyl-ethanoyl]amino]-7-oxidanylidene-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
59. (2s,5r,6r)-3,3-dimethyl-6-[[(2r)-2-[[(3-methylsulfonyl-2-oxo-1-imidazolidinyl)-oxomethyl]amino]-1-oxo-2-phenylethyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
60. (2s,5r,6r)-6-[(2r)-2-{[(3-methanesulfonyl-2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
61. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-6-(((((3-(methylsulfonyl)-2-oxo-1-imidazolidinyl)carbonyl)amino)phenylacetyl)amino)-7-oxo-, (2s-(2.alpha.,5.alpha.,6.beta.(s*)))
62. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-6-(((((3-(methylsulfonyl)-2-oxo-1-imidazolidinyl)carbonyl)amino)phenylacetyl)amino)-7-oxo-, (2s-(2alpha,5alpha,6beta(s*)))
63. 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid, 3,3-dimethyl-6-[[(2r)-2-[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]-2-phenylacetyl]amino]-7-oxo-, (2s,5r,6r)-
| Molecular Weight | 539.6 g/mol |
|---|---|
| Molecular Formula | C21H25N5O8S2 |
| XLogP3 | -0.2 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 6 |
| Exact Mass | 539.11445512 g/mol |
| Monoisotopic Mass | 539.11445512 g/mol |
| Topological Polar Surface Area | 207 Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 1080 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Used to treat serious gram–negative infections of the lungs, urinary tract, and skin.
Mezlocillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Mezlocillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of mezlocillin results from the inhibition of cell wall synthesis and is mediated through mezlocillin binding to penicillin binding proteins (PBPs). Mezlocillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Mezlocillin can be used to treat susceptible strains of H. influenzae, Klebsiella species, Pseudomonas species, Proteus mirabilis, E. coli, Enterobacter species, Streptococcus faecelis, Peptococcus species, Peptostreptococcus species, Bacteriodes species (including B. fragilis), Morganella morganii, Serratia species, N. gonorrhoeae, P. vulgaris, and Providencia rettgeri. This drug is discontinued in the U.S.
Anti-Bacterial Agents
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
J - Antiinfectives for systemic use
J01 - Antibacterials for systemic use
J01C - Beta-lactam antibacterials, penicillins
J01CA - Penicillins with extended spectrum
J01CA10 - Mezlocillin
Unlike many other penicillins, mezlocillin is either extensively metabolized or is subject to biliary excretion, as only about 50% of the dose was accounted for in normal urine.
1.3 to 4.4 hours
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that mezlocillin interferes with an autolysin inhibitor.
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