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    Mevrometostat

    DEVELOPMENTS

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    2D Structure
    Also known as: 1844849-10-0, Mevrometostat, S4l4mm20b6, Pf06821497, 1(2h)-isoquinolinone, 5,8-dichloro-2-((1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl)-3,4-dihydro-7-((r)-methoxy-3-oxetanylmethyl)-, 1(2h)-isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-3,4-dihydro-7-[(r)-methoxy-3-oxetanylmethyl]-
    Molecular Formula
    C22H24Cl2N2O5
    Molecular Weight
    467.3  g/mol
    InChI Key
    RXCVUHMIWHRLDF-HXUWFJFHSA-N
    FDA UNII
    S4L4MM20B6
    zeste homolog 2 inhibitor
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one
    2.1.2 InChI
    InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1
    2.1.3 InChI Key
    RXCVUHMIWHRLDF-HXUWFJFHSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    S4L4MM20B6
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Pf06821497

    2.3.2 Depositor-Supplied Synonyms

    1. 1844849-10-0

    2. Mevrometostat

    3. S4l4mm20b6

    4. Pf06821497

    5. 1(2h)-isoquinolinone, 5,8-dichloro-2-((1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl)-3,4-dihydro-7-((r)-methoxy-3-oxetanylmethyl)-

    6. 1(2h)-isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-3,4-dihydro-7-[(r)-methoxy-3-oxetanylmethyl]-

    7. 5,8-dichloro-2-((4-methoxy-6-methyl-2-oxo-1h-pyridin-3-yl)methyl)-7-((r)-methoxy(oxetan-3-yl)methyl)-3,4-dihydroisoquinolin-1-one

    8. 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1h-pyridin-3-yl)methyl]-7-[(r)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one

    9. Pf 06821497

    10. Refchem:172264

    11. Ezh2 Inhibitor Pf-06821497

    12. 5,8-dichloro-7-((r)-methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1,2,3,4-tetrahydroisoquinolin-1-one

    13. Unii-s4l4mm20b6

    14. (r)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2h)-one

    15. Chembl4080228

    16. 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(r)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2h)-one

    17. Mevrometostat [inn]

    18. Mevrometostat [who-dd]

    19. Mevrometostat (jan/usan)

    20. Mevrometostat [usan]

    21. Orb1963604

    22. Schembl17330426

    23. Schembl29406728

    24. Gtpl10516

    25. Bdbm50246967

    26. Ex-a11760

    27. Nsc800019

    28. Akos040734437

    29. Db14799

    30. Hy-101571a

    31. Nsc-800019

    32. Compound 23a [pmid: 29211475]

    33. Ncgc00510267-02

    34. Da-76781

    35. Ts-07857

    36. Cs-0092626

    37. D12845

    38. H68040

    39. P200097

    40. Q29209799

    41. 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(r)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoqinolin-1(2h)-one

    42. 5,8-dichloro-7-[(r)-methoxy(oxetan-3-yl)methyl]-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2h)-one

    43. Cjd

    2.4 Create Date
    2016-02-23
    3 Chemical and Physical Properties
    Molecular Weight 467.3 g/mol
    Molecular Formula C22H24Cl2N2O5
    XLogP32.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count6
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area77.1
    Heavy Atom Count31
    Formal Charge0
    Complexity797
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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