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Technical details about Memantine, learn more about the structure, uses, toxicity, action, side effects and more

Memantine

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

66 Suppliers, 34 USDMF, 11 JDMF, 15 EU WC, 25 KDMF, 30 NDC API, 37 Listed Suppliers

DEVELOPMENTS

4 Drug(s) in Development

4 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

15 Suppliers

15 Suppliers

DOSSIERs // Finished Dosage Forms

460 Dossiers, 125 FDA Orange Book, 230 Europe, 11 Canada, 14 Australia, 8 South Africa, 72 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - 10MG, TABLET;ORAL - 5MG, CAPSULE, EXTENDED RELEASE;ORAL - 14MG, CAPSULE, EXTENDED RELEASE;ORAL - 21MG, CAPSULE, EXTENDED RELEASE;ORAL - 28MG, CAPSULE, EXTENDED RELEASE;ORAL - 7MG

RELATED EXCIPIENT COMPANIES

Suppliers, 37 Kerry, 27 Roquette, 26 BASF, 12 Sigachi Industries, 12 Gangwal Healthcare, 12 Microlex e.U, 11 Corel Pharma Chem, 11 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 9 Gangwal Chemicals, 8 Seppic, 8 SPI Pharma, 8 Nanjing Well Pharmaceutical, 8 Actylis, 7 DFE Pharma, 7 Ideal Cures Pvt Ltd, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 6 Lonza Capsugel, 5 Prachin Chemical, 4 Boai NKY Pharmaceuticals Ltd, 4 Kima Chemical, 4 Vasa Pharmachem, 4 Pharmatrans-Sanaq, 4 ACG Worldwide, 4 Ingredion Pharma Solutions, 3 DKSH, 3 The Dow Chemical Company, 2 Rochem International Inc, 2 Nomisma Healthcare, 2 Ulanqab Kema New Material, 2 Seqens, 2 Finar, 2 Jai Radhe Sales, 2 Clariant, 2 Qualicaps, 1 Pfanstiehl, 1 Chynops Pharma, 1 Alcedo Pharmachem, 1 Zhejiang Huakang Pharmaceutical, 1 Minakem, 1 Vertellus, 1 Avesta Pharma, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Aeon Procare, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Bioplus Life Sciences, 1 Shanghai Welltone Material Technology Co., Ltd, 1 NEWEDGE Overseas, 1 Pharm-RX Chemical

EXCIPIENTS BY APPLICATIONS

79 Fillers, Diluents & Binders, 58 Coating Systems & Additives, 37 Controlled & Modified Release, 35 Disintegrants & Superdisintegrants, 33 Direct Compression, 26 Film Formers & Plasticizers, 25 Granulation, 24 Thickeners and Stabilizers, 24 Lubricants & Glidants, 20 Taste Masking, 18 Solubilizers, 16 Topical, 15 Parenteral, 13 Co-Processed Excipients, 10 Chewable & Orodispersible Aids, 9 Empty Capsules, 6 API Stability Enhancers, 5 Emulsifying Agents, 4 Vegetarian Capsules, 4 Rheology Modifiers, 3 Surfactant & Foaming Agents, 2 Coloring Agents, 1 Soft Gelatin

GLOBAL SALES INFORMATION

27 US Medicaid Prescriptions, 160 Finished Drug Prices

MARKET PLACE

13 APIs, 5 DOSSIERS // FDF

PATENTS

66 US Patents, 2 Health Canada Patents

ANALYTICAL SOLUTION(s)

1 BioAnalytical Methods, 6 USP Standards, 14 Other Ref. Standards

DIGITAL CONTENT

4 Data Compilation & Company Tracker #PharmaFlow, 84 News

Also known as: 41100-52-1, Memantine hcl, Namenda, 3,5-dimethyl-1-adamantanamine hydrochloride, 3,5-dimethyladamantan-1-amine hydrochloride, Akatinol

Molecular Formula

C₁₂H₂₂ClN

Molecular Weight

215.76 g/mol

InChI Key

LDDHMLJTFXJGPI-UHFFFAOYSA-N

FDA UNII

JY0WD0UA60

AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3,5-dimethyladamantan-1-amine;hydrochloride

2.1.2 InChI

InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

2.1.3 InChI Key

LDDHMLJTFXJGPI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

2.2 Other Identifiers

2.2.1 UNII

JY0WD0UA60

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1,3-dimethyl-5-aminoadamantane

2. 1-amino-3,5-dimethyladamantane

3. Axura

4. D 145

5. D-145

6. D145

7. Ebixa

8. Memantin

9. Memantine

10. Namenda

2.3.2 Depositor-Supplied Synonyms

1. 41100-52-1

2. Memantine Hcl

3. Namenda

4. 3,5-dimethyl-1-adamantanamine Hydrochloride

5. 3,5-dimethyladamantan-1-amine Hydrochloride

6. Akatinol

7. Axura

8. Namenda Xr

9. Memary

10. Ebixa

11. Memantine Mylan

12. 1-amino-3,5-dimethyladamantane Hydrochloride

13. Memantine Merz

14. Memantine.hcl

15. Memantine Accord

16. Memantine Lek

17. Memantine (hydrochloride)

18. Acrescent

19. Balaxur

20. Auxura

21. Unii-jy0wd0ua60

22. 3,5-dimethyladamantan-1-amine;hydrochloride

23. Jy0wd0ua60

24. Mfcd00214336

25. Memantine Ratiopharm

26. Memantine Hydrochloride [usan]

27. Chebi:64323

28. Sun-y7017

29. Nsc-102290

30. 3,5-dimethyladamantan-1-aminium Chloride

31. D-145

32. Mls001332605

33. 3,5-dimethyl-1-aminoadamantane Hydrochloride

34. (3,5-dimethyl-1-adamantyl)amine Hydrochloride

35. 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine Hydrochloride

36. Fp-01

37. 1,3-dimethyl-5-adamantanamine Hcl

38. 3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine Hydrochloride

39. 41100-52-1 (hcl)

40. Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, Hydrochloride

41. D 145

42. Mantine

43. Ebixza

44. 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine Hydrochloride

45. 3,5-dimethyltricyclo(3.3.1.13,7)decan-1-amine Hydrochloride

46. 3,5-dimethyltricyclo(3.3.1.1(sup 3,7))decan-1-amine Hydrochloride

47. Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, 3,5-dimethyl-, Hydrochloride

48. 3,5-dimethyl-1-adamantylamine

49. 3,5-dimethyl-1-aminoadamantane

50. Smr000875213

51. Sr-01000075458

52. Sun Y7017

53. Einecs 255-219-6

54. Namenda (tn)

55. Memary (tn)

56. Marixino

57. Nsc 102290

58. D-145 (hydrochloride)

59. Schembl3053

60. C12h21n.hcl

61. Chembl1699

62. Mls001332606

63. Spectrum1501121

64. Hy-b0365a

65. Dtxsid90961439

66. Memantine Hydrochloride (namenda)

67. N06dx01

68. Nmi-131

69. Hms1571c17

70. Hms1921h03

71. Pharmakon1600-01501121

72. Memantine Hydrochloride (jan/usp)

73. Memantine Hydrochloride [mi]

74. Tox21_500861

75. Ac-559

76. Ccg-39018

77. Memantine Hydrochloride [jan]

78. Mrz-2/145

79. Nsc102290

80. Nsc757843

81. S2043

82. Akos015889460

83. Bcp9000253

84. Lp00861

85. Memantine Hydrochloride [mart.]

86. Nc00680

87. Memantine Hydrochloride [usp-rs]

88. Memantine Hydrochloride [who-dd]

89. Ncgc00094186-01

90. Ncgc00094186-02

91. Ncgc00094186-03

92. Ncgc00261546-01

93. As-13331

94. Bm164662

95. Memantine Hydrochloride [ema Epar]

96. Sy057917

97. 3,5-dimethyladamantan-1-aminehydrochloride

98. Am20070534

99. D3608

100. Eu-0100861

101. Ft-0650723

102. M-145

103. Memantine Hydrochloride [orange Book]

104. Sw060653-4

105. 1-amino-3,5-dimethyl-adamantane Hydrochloride

106. 3,5-dimethyladamantan-1-amine Hy-drochloride

107. 3,5-dimethyladamantan-1-amine;hydrochloride.

108. D04905

109. M 9292

110. Memantine Hydrochloride [usp Monograph]

111. Namzaric Component Memantine Hydrochloride

112. Memantine Hydrochloride Component Of Namzaric

113. Sr-01000075458-1

114. Sr-01000075458-3

115. Sr-01000075458-8

116. Q27133218

117. Z1551429722

118. Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, Hydrochloride

119. Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-, Hydrochloride (1:1) (ca Index Name)

120. 1-amino-3,5-dimethyladamantane . Hcl 3,5-dimethyl-1-aminoadamantane . Hcl Memantine . Hydrochloride

2.4 Create Date

2005-07-19

3 Chemical and Physical Properties

Molecular Formula	C₁₂H₂₂ClN
Molecular Weight	215.76 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	215.1440774 g/mol
Monoisotopic Mass	215.1440774 g/mol
Topological Polar Surface Area	26 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	240
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Memantine hydrochloride
PubMed Health	Memantine (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Namenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active Ingredient	Memantine hydrochloride
Dosage Form	Tablet
Route	oral; Oral
Strength	5mg; 10mg
Market Status	Tentative Approval
Company	Amneal Pharms; Alembic; Upsher Smith; Mylan Pharma; Unichem Pharms (usa); Apotex; Lupin Pharms; Aurobindo Pharma; Torrent Pharms; Macleods Pharms; Jubilant Life

2 of 6
Drug Name	Namenda
PubMed Health	Memantine (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Namenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active Ingredient	Memantine hydrochloride
Dosage Form	Tablet; Solution
Route	Oral
Strength	2mg/ml; 5mg; 10mg
Market Status	Prescription
Company	Forest Labs

3 of 6
Drug Name	Namenda xr
Drug Label	NAMENDA XR is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21NHCl and the molecular wei...
Active Ingredient	Memantine hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	7mg; 14mg; 21mg; 28mg
Market Status	Prescription
Company	Forest Labs

4 of 6
Drug Name	Memantine hydrochloride
PubMed Health	Memantine (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Namenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active Ingredient	Memantine hydrochloride
Dosage Form	Tablet
Route	oral; Oral
Strength	5mg; 10mg
Market Status	Tentative Approval
Company	Amneal Pharms; Alembic; Upsher Smith; Mylan Pharma; Unichem Pharms (usa); Apotex; Lupin Pharms; Aurobindo Pharma; Torrent Pharms; Macleods Pharms; Jubilant Life

5 of 6
Drug Name	Namenda
PubMed Health	Memantine (By mouth)
Drug Classes	Central Nervous System Agent
Drug Label	Namenda (memantine hydrochloride) is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21N...
Active Ingredient	Memantine hydrochloride
Dosage Form	Tablet; Solution
Route	Oral
Strength	2mg/ml; 5mg; 10mg
Market Status	Prescription
Company	Forest Labs

6 of 6
Drug Name	Namenda xr
Drug Label	NAMENDA XR is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C12H21NHCl and the molecular wei...
Active Ingredient	Memantine hydrochloride
Dosage Form	Capsule, extended release
Route	Oral
Strength	7mg; 14mg; 21mg; 28mg
Market Status	Prescription
Company	Forest Labs

4.2 Drug Indication

Treatment of patients with moderate to severe Alzheimer's disease.

Treatment of patients with moderate to severe Alzheimers disease.

Treatment of patients with moderate to severe Alzheimer's disease.

Treatment of patients with moderate to severe Alzheimers disease

Treatment of patients with moderate to severe Alzheimers disease.

Treatment of Alzheimers disease

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

Dopamine Agents

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. (See all compounds classified as Dopamine Agents.)

Excitatory Amino Acid Antagonists

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

NMDA Receptor Antagonists [MoA]; N-methyl-D-aspartate Receptor Antagonist [EPC]

5.3 ATC Code

N06DX01

N06D

N06DA52

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