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    Technical details about Melengestrol Acetate, learn more about the structure, uses, toxicity, action, side effects and more

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    Melengestrol Acetate

    APIs // Active Pharmaceutical Ingredients

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    REF. STANDARDS & IMPURITIES

    PharmaCompass

    Boai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.

    Renejix: CDMO with expertise in small molecule oral dosage, delivery tech, and multi-modality manufacturing.

    2D Structure
    1. Also known as: 2919-66-6, Bdh 1921, Nsc-70968, Mga 100, Mga 500, 17-hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione acetate
    Molecular Formula
    C25H32O4
    Molecular Weight
    396.5  g/mol
    InChI Key
    UDKABVSQKJNZBH-DWNQPYOZSA-N
    FDA UNII
    4W5HDS3936
    A 6-methyl PROGESTERONE acetate with reported glucocorticoid activity and effect on ESTRUS.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] acetate
    2.1.2 InChI
    InChI=1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1
    2.1.3 InChI Key
    UDKABVSQKJNZBH-DWNQPYOZSA-N
    2.1.4 Canonical SMILES
    CC1=CC2C(CCC3(C2CC(=C)C3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C
    2.1.5 Isomeric SMILES
    CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC(=C)[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
    2.2 Other Identifiers
    2.2.1 UNII
    4W5HDS3936
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acetate, Melengestrol

    2. Melengestrol

    2.3.2 Depositor-Supplied Synonyms

    1. 2919-66-6

    2. Bdh 1921

    3. Nsc-70968

    4. Mga 100

    5. Mga 500

    6. 17-hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione Acetate

    7. Mls001332590

    8. [(8r,9s,10r,13s,14s,17r)-17-acetyl-6,10,13-trimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] Acetate

    9. Chebi:34831

    10. 17a-acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione

    11. 17-(acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione

    12. 4w5hds3936

    13. Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-16-methylene-

    14. Mga

    15. Dsstox_cid_28158

    16. Dsstox_rid_82720

    17. Dsstox_gsid_48184

    18. Melengestrol Acetate 100 Microg/ml In Acetonitrile

    19. Mga, Veterinary

    20. Malengestrol Acetate

    21. Mga (veterinary)

    22. Smr000857077

    23. Cas-2919-66-6

    24. Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-16-methylene-, Acetate

    25. Mga 100 (steroid)

    26. Melengestrol Acetate [usan]

    27. Nsc70968

    28. Unii-4w5hds3936

    29. Ccris 7800

    30. Melengestrol Acetate [usan:usp]

    31. Ncgc00160544-01

    32. Einecs 220-859-7

    33. Nsc 70968

    34. Melengestrol Acetate (usp)

    35. Schembl4520

    36. Mls001332589

    37. 6-dehydro-16-methylene-6-methyl-17-acetoxyprogesterone

    38. Chembl1328968

    39. Dtxsid5048184

    40. Melengestrol Acetate [mi]

    41. Hms2090n06

    42. Hms2233n13

    43. Hms3715d05

    44. Zinc4216828

    45. Tox21_111887

    46. Tox21_303411

    47. Melengestrol Acetate [mart.]

    48. Melengestrol Acetate [usp-rs]

    49. Akos015895715

    50. Tox21_111887_1

    51. Ccg-221132

    52. Db14659

    53. Melengestrol Acetate [green Book]

    54. Ncgc00166298-01

    55. Ncgc00166298-02

    56. Ncgc00257329-01

    57. Bs-42198

    58. Melengestrol Acetate, >=97.0% (hplc)

    59. Hy-111614

    60. Melengestrol Acetate [usp Monograph]

    61. Cs-0088572

    62. D04900

    63. Ab00918404-04

    64. 919m666

    65. Q6812180

    66. W-107000

    67. 17-(acetyloxy)-6-methyl-16-methylenepregna-4,20-dione

    68. Melengestrol Acetate, Vetranal(tm), Analytical Standard

    69. 17-hydroxy-6-methyl-16-methylenepregna-4,20-dione Acetate

    70. Pregna-4,20-dione, 17-(acetyloxy)-6-methyl-16-methylene-

    71. 17alpha-acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione

    72. 17alpha-acetoxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione

    73. Pregna-4,20-dione, 17-hydroxy-6-methyl-16-methylene-, Acetate

    74. Melengestrol Acetate, United States Pharmacopeia (usp) Reference Standard

    75. (8r,9s,10r,13s,14s,17r)-17-acetyl-6,10,13-trimethyl-16-methylene-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl Acetate

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 396.5 g/mol
    Molecular Formula C25H32O4
    XLogP33.1
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass396.23005950 g/mol
    Monoisotopic Mass396.23005950 g/mol
    Topological Polar Surface Area60.4 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity893
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

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