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Polpharma European CDMO Partner & API Manufacturer since 1951 Polpharma European CDMO Partner & API Manufacturer since 1951

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    Technical details about Masupirdine, learn more about the structure, uses, toxicity, action, side effects and more

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    Masupirdine

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    2D Structure
    1. Also known as: Suvn-502, Masupirdine, 701205-60-9, Masupirdine (free base), 8xz281ao3g, 701205-60-9 (free base).
    Molecular Formula
    C21H24BrN3O3S
    Molecular Weight
    478.4  g/mol
    InChI Key
    GWCYPEHWIZXYFZ-UHFFFAOYSA-N
    FDA UNII
    8XZ281AO3G
    SUVN-502 is a novel, potent, safe, highly selective and orally active antagonist at a central nervous system serotonin receptor site 5-HT6 intended for treatment of cognitive disorders such as Alzheimers and Schizophrenia, an unmet medical need.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(2-bromophenyl)sulfonyl-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]indole
    2.1.2 InChI
    InChI=1S/C21H24BrN3O3S/c1-23-9-11-24(12-10-23)14-16-15-25(20-8-7-17(28-2)13-18(16)20)29(26,27)21-6-4-3-5-19(21)22/h3-8,13,15H,9-12,14H2,1-2H3
    2.1.3 InChI Key
    GWCYPEHWIZXYFZ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)CC2=CN(C3=C2C=C(C=C3)OC)S(=O)(=O)C4=CC=CC=C4Br
    2.2 Other Identifiers
    2.2.1 UNII
    8XZ281AO3G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methyl-1-piperazinyl)methyl)-1h-indole Dimesylate Monohydrate

    2. Suvn-502

    2.3.2 Depositor-Supplied Synonyms

    1. Suvn-502

    2. Masupirdine

    3. 701205-60-9

    4. Masupirdine (free Base)

    5. 8xz281ao3g

    6. 701205-60-9 (free Base).

    7. Masupirdin

    8. Masupirdine [inn]

    9. Unii-8xz281ao3g

    10. Schembl946320

    11. Chembl4117187

    12. Us11116764, Compound 1

    13. Bdbm518688

    14. 1-(2-bromophenyl)sulfonyl-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]indole

    15. Db06140

    16. Hy-109118

    17. Cs-0078331

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 478.4 g/mol
    Molecular Formula C21H24BrN3O3S
    XLogP33.5
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count5
    Exact Mass477.07218 g/mol
    Monoisotopic Mass477.07218 g/mol
    Topological Polar Surface Area63.2 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity650
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Investigated for use/treatment in neurologic disorders.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Serotonin Antagonists

    Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)

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