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    Technical details about Lofexidine, learn more about the structure, uses, toxicity, action, side effects and more

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    Lofexidine

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    2D Structure
    1. Also known as: 21498-08-8, Lofexidine hcl, Lofexidine.hcl, Lofexidine (hydrochloride), Britlofex, Mdl 14,042
    Molecular Formula
    C11H13Cl3N2O
    Molecular Weight
    295.6  g/mol
    InChI Key
    DWWHMKBNNNZGHF-UHFFFAOYSA-N
    FDA UNII
    V47G1SDI1B
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride
    2.1.2 InChI
    InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H
    2.1.3 InChI Key
    DWWHMKBNNNZGHF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    V47G1SDI1B
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(alpha-(2,6-dichlorophenoxy)ethyl) Delta-2-imidazoline

    2. Britlofex

    3. Lofexidine

    4. Lofexidine Mono-hydrochloride

    5. Lofexidine Monohydrochloride

    6. Lofexidine, (+-)-isomer

    7. Lucemyra

    2.3.2 Depositor-Supplied Synonyms

    1. 21498-08-8

    2. Lofexidine Hcl

    3. Lofexidine.hcl

    4. Lofexidine (hydrochloride)

    5. Britlofex

    6. Mdl 14,042

    7. Lofexidine Hydrochloride [usan]

    8. Mdl-14042

    9. Nsc-759654

    10. V47g1sdi1b

    11. 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1h-imidazole Hydrochloride

    12. 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1h-imidazole;hydrochloride

    13. Lucemyra

    14. Lofetensin

    15. Loxacor

    16. Baq-168;mdl-14042

    17. 2-(1-(2,6-dichlorophenoxy)ethyl)-2-imidazoline Monohydrochloride

    18. 1h-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, Monohydrochloride

    19. Lofexidine Hydrochloride (usan)

    20. 2-(1-(2,6-dichlorophenoxy)ethyl)-2-imidazoline Hydrochloride

    21. 2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline Hydrochloride

    22. Loxacor Hydrochloride

    23. Lofetensin Hydrochloride

    24. Lofexidine Hcl

    25. Lofexidine (tn)

    26. Rmi-14042a

    27. Lucemyra (tn)

    28. Ba 168

    29. Mfcd00917022

    30. Unii-v47g1sdi1b

    31. Mls001424245

    32. Schembl124601

    33. Chembl1788132

    34. Dtxsid0020781

    35. Pharmakon1600-01502357

    36. Bcp30600

    37. Hy-b1052

    38. 2-(1-(2,6-dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid [german]

    39. Lofexidine Hydrochloride [mi]

    40. Nsc759654

    41. Zb0287

    42. 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1h-imidazole Hydrochloride

    43. 2-imidazoline, 2-(1-(2,6-dichlorophenoxy)ethyl)-, Monohydrochloride

    44. Akos015902903

    45. Ccg-101139

    46. Ccg-213049

    47. Cs-4574

    48. Nc00389

    49. Nsc 759654

    50. (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene Hydrochloride

    51. Lofexidine Hydrochloride [mart.]

    52. Lofexidine Hydrochloride [vandf]

    53. Lofexidine Hydrochloride [who-dd]

    54. As-31095

    55. Smr000469232

    56. Ft-0651655

    57. Ft-0670833

    58. Sw197769-3

    59. Lofexidine Hydrochloride [orange Book]

    60. D04765

    61. 498l088

    62. A815419

    63. J-014106

    64. Q27291521

    65. 2-(1-(2,6-dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid

    66. 2-[1-(2,6-dichlorophenoxy) -ethyl]2-imidazoline Hydrochloride

    67. 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1h-imidazolehydrochloride

    68. Lofexidine Hcl;lofexidine Monohydrochloride;baq-168; Mdl-14042;ba 168;mdl 14,042

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 295.6 g/mol
    Molecular Formula C11H13Cl3N2O
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass294.009346 g/mol
    Monoisotopic Mass294.009346 g/mol
    Topological Polar Surface Area33.6 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity263
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Narcotic Antagonists

    Agents inhibiting the effect of narcotics on the central nervous system. (See all compounds classified as Narcotic Antagonists.)

    Adrenergic alpha-2 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

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