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1. (+)-4-epi-alpha-bisabolol
2. Bisabolol
3. Bisabolol, (+)-isomer
4. Bisabolol, (-)-isomer
1. (-)-alpha-bisabolol
2. 23089-26-1
3. Alpha-bisabolol
4. Kamillosan
5. Bisabolol
6. Alpha-(-)-bisabolol
7. .alpha.-bisabolol
8. Levomenol [inn]
9. (-)-.alpha.-bisabolol
10. (-)-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol
11. Alpha-bisabolol (-)-form
12. Bisabolol, (-)-.alpha.
13. (2s)-6-methyl-2-[(1s)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol
14. .alpha.-bisabolol, (-)-
15. Chebi:125
16. .alpha.-bisabolol (-)-form
17. 24we03bx2t
18. Fema No. 4666
19. (.alpha.s,1s)-.alpha.-bisabolol
20. 3-cyclohexene-1-methanol, A,4-dimethyl-a-(4-methyl-3-pentenyl)-,(as,1s)-
21. 3-cyclohexene-1-methanol, Alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (alphas,1s)-
22. Levomenolum
23. Kamilosan
24. ((-))-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol
25. (s)-6-methyl-2-((s)-4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol
26. 515-69-5
27. 1-alpha-bisabolol
28. Alpha-bisabolol, L-
29. Levomenolum [inn-latin]
30. Unii-24we03bx2t
31. Bisbalol
32. Ccris 9081
33. L-alpha-bisabolol
34. Levomenol, Inn
35. 3-cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, [s-(r*,r*)]-
36. (-)-a-bisabolol
37. Einecs 245-423-3
38. L-.alpha.-bisabolol
39. .alpha.-bisabolol, L-
40. Bisabolol [inci]
41. (-)- Alpha -bisabolol
42. .alpha.-(-)-bisabolol
43. Bisabolol [vandf]
44. Levomenol [mart.]
45. (-)--bisabolol
46. Alpha-(-)bisabolol
47. Levomenol [usp-rs]
48. Levomenol [who-dd]
49. Dsstox_cid_22094
50. Dsstox_rid_79924
51. Dsstox_gsid_42094
52. Schembl24989
53. Chembl1096927
54. Dtxsid4042094
55. (-)-(4s,8s)-alpha-bisabolol
56. Hy-n6967
57. Zinc1849759
58. [s-(r*,r*)]-.alpha.-bisabolol
59. Tox21_301375
60. 5-hepten-2-ol, 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-, (-)-
61. Bdbm50382730
62. Mfcd03412455
63. Nsc782530
64. Levomenol 100 Microg/ml In Methanol
65. Db13153
66. Lmpr0103060001
67. Nsc-782530
68. (-)-alpha-bisabolol, >=93% (gc)
69. (-)-alpha-bisabolol(-)-alpha-bisabolol
70. Ncgc00255987-01
71. (-)-alpha-bisabolol, Analytical Standard
72. .alpha.-bisabolol (-)-form [mi]
73. Cas-23089-26-1
74. Cs-0028206
75. Alpha-bisabolol 1000 Microg/ml In Isopropanol
76. C09621
77. Q179896
78. J-014978
79. (-)-alpha-bisabolol, Primary Pharmaceutical Reference Standard
80. Levomenol, United States Pharmacopeia (usp) Reference Standard
81. (-)-.alpha.-bisabolol (constituent Of Chamomile) [dsc]
82. 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, (-)-
83. 5-hepten-2-ol, 6-methyl-2-(4- Methyl-3-cyclohexen-1-yl), (-)-
84. [s-(r*,r*)]-.alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
85. 3-cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (-)-
86. 3-cyclohexene-1-methanol, Alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (.alpha.s,1s)-
87. Alpha,4-dimethyl-alpha-(4-methyl-3-penten-1-yl)-(alphas,1s)-3-cyclohexene-1-methanol
88. 3-cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-penten-1-yl)-, (.alpha.s,1s)-
89. 3-cyclohexene-1-methanol, Alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (s-(theta,theta))-
| Molecular Weight | 222.37 g/mol |
|---|---|
| Molecular Formula | C15H26O |
| XLogP3 | 3.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 4 |
| Exact Mass | 222.198365449 g/mol |
| Monoisotopic Mass | 222.198365449 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 284 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Levomenol has been known to elicit a number of potentially beneficial pharmacological effects, including anti-irritant, anti-inflammatory, and anti-microbial actions. Bisabolol is also demonstrated to enhance the percutaneous absorption of certain molecules
Levomenol is an anti-inflammatory and natural moisturizing agent that has been found to diminish the signs of photodamage, reduce pruritus, and ameliorate skin texture and elasticity.
Absorption
The purpose of the present investigations was to study the cutaneous absorption of sesquiterpenic alcohol, the major active principle of chamomile. For these investigations 14C-labelled levomenol ((-)-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; (-)-alpha-bisabolol) was prepared by biochemical incorporation of [14C]-acetate into the molecule. 5 h after topical application of the radiolabelled substance onto nude mice half of the radioactivity was found in the skin. The other part was measured in tissue and organes. 90% of this radioactivity was analysed as intact levomenol.
Volume of Distribution
To demonstrate the distribution of the substance in the skin a part of this tissue was cutted into horizontal slices by a cryotome. From the slices autoradiograms were produced. The densitometric measuration showed that there was a fast penetration of levomenol into the skin. 5 h after the topical application the substance was displaced from outermost to innermost areas. From these results a fast cutaneous absorption and a long therapeutical effect of the antiphlogistic and spasmolytic levomenol in the skin can be expected.
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