Please Wait
Applying Filters...
Menu
Xls
2D Structure
Also known as: 149951-16-6, Lenapenem [inn], Unii-d6nbq3h12u, D6nbq3h12u, (4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-3-[(3s,5s)-5-[(1r)-1-hydroxy-3-(methylamino)propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, Bo2727
Molecular Formula
C18H29N3O5S
Molecular Weight
399.5  g/mol
InChI Key
PZLOCBSBEUDCPF-YJIVIRPOSA-N
FDA UNII
D6NBQ3H12U

Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity. Lenapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. This inhibition weakens the bacterial cell wall and leads to lytic cell death in a wide range of Gram-positive and Gram-negative aerobic and anaerobic pathogens.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-3-[(3S,5S)-5-[(1R)-1-hydroxy-3-(methylamino)propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
2.1.2 InChI
InChI=1S/C18H29N3O5S/c1-8-14-13(9(2)22)17(24)21(14)15(18(25)26)16(8)27-10-6-11(20-7-10)12(23)4-5-19-3/h8-14,19-20,22-23H,4-7H2,1-3H3,(H,25,26)/t8-,9-,10+,11+,12-,13-,14-/m1/s1
2.1.3 InChI Key
PZLOCBSBEUDCPF-YJIVIRPOSA-N
2.2 Other Identifiers
2.2.1 UNII
D6NBQ3H12U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-(1-hydroxyethyl)-2-(5-(1-hydroxy-3-n-methylaminopropyl)pyrrolidin-3-ylthio)1-methyl-1-carbapen-2-em-3-carboxylic Acid Hydrochloride Hydrate

2. Bo 2727

3. Bo-2727

4. L 739,428

5. L 739428

6. L-739,428

7. L-739428

2.3.2 Depositor-Supplied Synonyms

1. 149951-16-6

2. Lenapenem [inn]

3. Unii-d6nbq3h12u

4. D6nbq3h12u

5. (4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-3-[(3s,5s)-5-[(1r)-1-hydroxy-3-(methylamino)propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

6. Bo2727

7. (+)-(4r,5s,6s)-6-((r)-1-hydroxyethyl)-3-(((3s,5s)-5-((r)-1-hydroxy-3-(methylamino)propyl)-3-pyrrolidinyl)thio)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid

8. L-739,428

9. L-739428

10. Lenapenemum

11. (4r,5s,6s)-6-((1r)-1-hydroxyethyl)-3-((3s,5s)-5-((1r)-1-hydroxy-3-(methylamino)propyl)pyrrolidin-3-yl)sulfanyl-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid

12. Bo-2727

13. (4r,5s,6s)-3-(((3s,5s)-5-((r)-1-hydroxy-3-(methylamino)propyl)pyrrolidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

14. 6-(1-hydroxyethyl)-2-(5-(1-hydroxy-3-n-methylaminopropyl)pyrrolidin-3-ylthio)1-methyl-1-carbapen-2-em-3-carboxylic Acid Hydrochloride Hydrate

15. Schembl75702

16. Chembl3989459

17. Gtpl10825

18. Dtxsid701031259

19. Da-64916

20. Hy-105180

21. Cs-0025215

22. Ns00124580

23. Q27276182

24. (+)-(4r,5s,6s)-6-((r)-1-hydroxyethyl)-3-((3s,5s)-5-((r)-1-hydroxy-3-(methyl-amino)propyl)-3-pyrrolidinyl)thio)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid

25. (1r,5s,6s)-6-[1(r)-hydroxyethyl]-2-[2(s)-[1(r)-hydroxy-3-(methylamino)propyl]pyrrolidin-4(s)-ylthio]-1-methyl-1-carba-2-penem-3-carboxylic Acid Monohydrochloride Monohydrate

26. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid, 6-[(1r)-1-hydroxyethyl]-3-[[(3s,5s)-5-[(1r)-1-hydroxy-3-(methylamino)propyl]-3-pyrrolidinyl]thio]-4-methyl-7-oxo-, (4r,5s,6s)-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 399.5 g/mol
Molecular Formula C18H29N3O5S
XLogP3-2.5
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area147
Heavy Atom Count27
Formal Charge0
Complexity642
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1