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Technical details about Interferon Beta-1A, learn more about the structure, uses, toxicity, action, side effects and more

Product

Interferon Beta-1A

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

2 Suppliers, 2 Listed Suppliers

DEVELOPMENTS

26 Drug(s) in Development

26 Drug(s) in Development

DOSSIERs // Finished Dosage Forms

65 Dossiers, 3 FDA Orange Book, 46 Europe, 5 Canada, 8 South Africa, 3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 12 SPI Pharma, 3 Roquette, 3 Kerry, 2 Seppic, 2 Gangwal Healthcare, 2 Actylis, 2 DKSH, 2 Gangwal Chemicals, 2 BASF, 2 Microlex e.U, 1 Nanjing Well Pharmaceutical, 1 Ingredion Pharma Solutions, 1 Sigachi Industries, 1 Pfanstiehl, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Rochem International Inc

EXCIPIENTS BY APPLICATIONS

18 Fillers, Diluents & Binders, 10 Direct Compression, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 7 Parenteral, 4 Solubilizers, 4 Co-Processed Excipients, 3 Disintegrants & Superdisintegrants, 3 Granulation, 3 Topical, 1 Surfactant & Foaming Agents, 1 Thickeners and Stabilizers, 1 API Stability Enhancers, 1 Controlled & Modified Release, 1 Coating Systems & Additives

GLOBAL SALES INFORMATION

17 US Medicaid Prescriptions, 33 Finished Drug Prices

MARKET PLACE

1 APIs, 4 DOSSIERS // FDF

PATENTS

3 Health Canada Patents

3 Health Canada Patents

ANALYTICAL SOLUTION(s)

1 EDQM Standards, 1 Other Ref. Standards

DIGITAL CONTENT

1 Data Compilation & Company Tracker #PharmaFlow, 31 News

PharmaCompass

Interferon Beta-1A
Chemistry
Full Screen View

2D Structure

Also known as: 79113-16-9, Itf-ecp, Interferon eicosapeptide (human lymphoblastoid), L-glutamine, l-seryl-l-alpha-aspartyl-l-leucyl-l-prolyl-l-glutaminyl-l-threonyl-l-histidyl-l-seryl-l-leucylglycyl-l-asparaginyl-l-arginyl-l-arginyl-l-alanyl-l-leucyl-l-isoleucyl-l-leucyl-l-leucyl-l-alanyl-

Molecular Formula

C₉₅H₁₆₃N₃₁O₂₉

Molecular Weight

2203.5 g/mol

InChI Key

RMQWCBKEQJCYKV-DEMAMGHZSA-N

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(4H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-oxopentanoic acid

2.1.2 InChI

InChI=1S/C95H163N31O29/c1-16-48(12)73(90(151)120-60(32-45(6)7)83(144)119-59(31-44(4)5)82(143)110-49(13)75(136)115-57(93(154)155)24-26-69(98)131)124-87(148)61(33-46(8)9)116-76(137)50(14)109-79(140)54(20-17-27-105-94(100)101)112-80(141)55(21-18-28-106-95(102)103)113-85(146)63(36-70(99)132)111-71(133)39-107-78(139)58(30-43(2)3)118-88(149)66(41-128)123-84(145)62(35-52-38-104-42-108-52)121-91(152)74(51(15)129)125-81(142)56(23-25-68(97)130)114-89(150)67-22-19-29-126(67)92(153)65(34-47(10)11)122-86(147)64(37-72(134)135)117-77(138)53(96)40-127/h38,42-67,73-74,127-129H,16-37,39-41,96H2,1-15H3,(H2,97,130)(H2,98,131)(H2,99,132)(H,107,139)(H,109,140)(H,110,143)(H,111,133)(H,112,141)(H,113,146)(H,114,150)(H,115,136)(H,116,137)(H,117,138)(H,118,149)(H,119,144)(H,120,151)(H,121,152)(H,122,147)(H,123,145)(H,124,148)(H,125,142)(H,134,135)(H,154,155)(H4,100,101,105)(H4,102,103,106)/t48-,49-,50-,51+,52?,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,73-,74-/m0/s1

2.1.3 InChI Key

RMQWCBKEQJCYKV-DEMAMGHZSA-N

2.1.4 Canonical SMILES

CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CC1C=NC=N1)NC(=O)C(C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)N

2.1.5 Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC1C=NC=N1)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)N

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Interferon Eicosapeptide (human Lymphoblastoid)

2. Itf-ecp

2.2.2 Depositor-Supplied Synonyms

1. 79113-16-9

2. Itf-ecp

3. Interferon Eicosapeptide (human Lymphoblastoid)

4. L-glutamine, L-seryl-l-alpha-aspartyl-l-leucyl-l-prolyl-l-glutaminyl-l-threonyl-l-histidyl-l-seryl-l-leucylglycyl-l-asparaginyl-l-arginyl-l-arginyl-l-alanyl-l-leucyl-l-isoleucyl-l-leucyl-l-leucyl-l-alanyl-

2.3 Create Date

2009-08-20

3 Chemical and Physical Properties

Molecular Formula	C₉₅H₁₆₃N₃₁O₂₉
Molecular Weight	2203.5 g/mol
XLogP3	-9.8
Hydrogen Bond Donor Count	33
Hydrogen Bond Acceptor Count	33
Rotatable Bond Count	75
Exact Mass	2203.2266531 g/mol
Monoisotopic Mass	2202.2232983 g/mol
Topological Polar Surface Area	983 Å²
Heavy Atom Count	155
Formal Charge	0
Complexity	4930
Isotope Atom Count	0
Defined Atom Stereocenter Count	21
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

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