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    Technical details about Hydromorphone Hydrochloride, learn more about the structure, uses, toxicity, action, side effects and more

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    Hydromorphone Hydrochloride

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

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    2D Structure
    1. Also known as: 71-68-1, Hydromorphone hcl, Dilaudid, Palladone, Hymorphan, Exalgo
    Molecular Formula
    C17H20ClNO3
    Molecular Weight
    321.8  g/mol
    InChI Key
    XHILEZUETWRSHC-NRGUFEMZSA-N
    FDA UNII
    L960UP2KRW
    An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1
    2.1.3 InChI Key
    XHILEZUETWRSHC-NRGUFEMZSA-N
    2.1.4 Canonical SMILES
    CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4.Cl
    2.1.5 Isomeric SMILES
    CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    L960UP2KRW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dihydromorphinone

    2. Dilaudid

    3. Hydromorphon

    4. Hydromorphone

    5. Laudacon

    6. Palladone

    2.3.2 Depositor-Supplied Synonyms

    1. 71-68-1

    2. Hydromorphone Hcl

    3. Dilaudid

    4. Palladone

    5. Hymorphan

    6. Exalgo

    7. Dihydromorphinone Hydrochloride

    8. Dilaudid-hp

    9. L960up2krw

    10. Hydromorphone Hydrochloride Cii

    11. Nsc-117862

    12. Dea No. 9150

    13. (4r,4ar,7ar,12bs)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride

    14. 4,5-alpha-epoxy-3-hydroxy-17-methylmorphinan-6-one Hydrochloride

    15. Chebi:5791

    16. Morphinone, Dihydro-, Hydrochloride

    17. Einecs 200-762-6

    18. Unii-l960up2krw

    19. Nsc 117862

    20. Hydromorphone Hydrochloride [usp]

    21. Palladone (tn)

    22. Dilaudid (tn)

    23. (4r,4ar,7ar,12bs)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride

    24. Exalgo (tn)

    25. 4,5alpha-epoxy-3-hydroxy-17-methylmorphinan-6-one Hydrochloride

    26. Schembl30521

    27. Hydromorphone Hydrochloride Usp

    28. Chembl1237055

    29. Dtxsid90991291

    30. Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl-, Hydrochloride

    31. Hydromorphone Hydrochloride (jan/usp)

    32. Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, Hydrochloride, (5alpha)-

    33. Hydromorphone Hydrochloride [mi]

    34. Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-, Hydrochloride, (5'-alpha)-

    35. Hydromorphone Hydrochloride [jan]

    36. Hydromorphone Hydrochloride [mart.]

    37. Hydromorphone Hydrochloride [vandf]

    38. Hydromorphone Hydrochloride [who-dd]

    39. D00839

    40. Hydromorphone Hydrochloride [orange Book]

    41. Hydromorphone Hydrochloride Cii [usp-rs]

    42. Hydromorphone Hydrochloride [ep Monograph]

    43. Hydromorphone Hydrochloride [usp Monograph]

    44. Q27106892

    45. 4,5.alpha.-epoxy-3-hydroxy-17-methylmorphinan-6-one Hydrochloride

    46. Hydromorphone Hydrochloride Solution, Drug Standard, 1.0 Mg/ml In Methanol

    47. Hydromorphone Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    48. Hydromorphone Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    49. Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, Hydrochloride (1:1), (5.alpha.)

    50. Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, Hydrochloride, (5.alpha.)-

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 321.8 g/mol
    Molecular Formula C17H20ClNO3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass321.1131712 g/mol
    Monoisotopic Mass321.1131712 g/mol
    Topological Polar Surface Area49.8 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity494
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameExalgo
    Drug LabelEXALGO tablets contain hydromorphone hydrochloride, a mu-opioid agonist.Hydromorphone hydrochloride USP is 4,5-epoxy-3-hydroxy-17-methlymorphinan-6-one hydrochloride. Hydromorphone hydrochloride is a white or almost white crystalline powder that...
    Active IngredientHydromorphone hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength32mg; 12mg; 16mg; 8mg
    Market StatusPrescription
    CompanyMallinckrodt

    2 of 4  
    Drug NameHydromorphone hydrochloride
    PubMed HealthHydromorphone
    Drug ClassesAnalgesic, Anesthetic Adjunct, Central Nervous System Agent
    Drug LabelHydromorphone Hydrochloride Tablets USP, 2 mg, 4 mg, and 8 mg are supplied in tablet form for oral administration.Hydromorphone hydrochloride, a hydrogenated ketone of morphine, is an opioid analgesic.The chemical name of hydromorphone hydrochloride...
    Active IngredientHydromorphone hydrochloride
    Dosage FormTablet, extended release; Tablet; Injectable; Solution
    RouteInjection; Oral
    Strength2mg/ml; 1mg/ml; 8mg; 10mg/ml; 4mg; 4mg/ml; 12mg; 2mg; 16mg; 5mg/5ml
    Market StatusPrescription
    CompanyHospira; Actavis Labs Fl; Mallinckrodt; Roxane; Lannett; Elite Labs; Akorn; Barr

    3 of 4  
    Drug NameExalgo
    Drug LabelEXALGO tablets contain hydromorphone hydrochloride, a mu-opioid agonist.Hydromorphone hydrochloride USP is 4,5-epoxy-3-hydroxy-17-methlymorphinan-6-one hydrochloride. Hydromorphone hydrochloride is a white or almost white crystalline powder that...
    Active IngredientHydromorphone hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength32mg; 12mg; 16mg; 8mg
    Market StatusPrescription
    CompanyMallinckrodt

    4 of 4  
    Drug NameHydromorphone hydrochloride
    PubMed HealthHydromorphone
    Drug ClassesAnalgesic, Anesthetic Adjunct, Central Nervous System Agent
    Drug LabelHydromorphone Hydrochloride Tablets USP, 2 mg, 4 mg, and 8 mg are supplied in tablet form for oral administration.Hydromorphone hydrochloride, a hydrogenated ketone of morphine, is an opioid analgesic.The chemical name of hydromorphone hydrochloride...
    Active IngredientHydromorphone hydrochloride
    Dosage FormTablet, extended release; Tablet; Injectable; Solution
    RouteInjection; Oral
    Strength2mg/ml; 1mg/ml; 8mg; 10mg/ml; 4mg; 4mg/ml; 12mg; 2mg; 16mg; 5mg/5ml
    Market StatusPrescription
    CompanyHospira; Actavis Labs Fl; Mallinckrodt; Roxane; Lannett; Elite Labs; Akorn; Barr

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Analgesics, Opioid

    Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

    Narcotics

    Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Opioid Agonist [EPC]; Full Opioid Agonists [MoA]
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