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    Technical details about Flurazepam Monohydrochloride, learn more about the structure, uses, toxicity, action, side effects and more

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    Flurazepam Monohydrochloride

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

    PharmaCompass

    Inke S.A: APIs manufacturing plant.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    1. Also known as: 36105-20-1, Dalmate, 7c4jh842ij, Dalmadorm, Dalmane, Felison
    Molecular Formula
    C21H24Cl2FN3O
    Molecular Weight
    424.3  g/mol
    InChI Key
    PUGVROXLRUQCAF-UHFFFAOYSA-N
    FDA UNII
    7C4JH842IJ
    A benzodiazepine derivative used mainly as a hypnotic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H23ClFN3O.ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;/h5-10,13H,3-4,11-12,14H2,1-2H3;1H
    2.1.3 InChI Key
    PUGVROXLRUQCAF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    7C4JH842IJ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apo Flurazepam

    2. Apo-flurazepam

    3. Dalmadorm

    4. Dalmane

    5. Dihydrochloride, Flurazepam

    6. Dormodor

    7. Flurazepam

    8. Flurazepam Dihydrochloride

    9. Flurazepam Hydrochloride

    10. Flurazepam Mono Perchlorate

    11. Flurazepam Mono-perchlorate

    12. Hydrochloride, Flurazepam

    13. Mono-perchlorate, Flurazepam

    14. Monohydrochloride, Flurazepam

    15. Staurodorm

    2.3.2 Depositor-Supplied Synonyms

    1. 36105-20-1

    2. Dalmate

    3. 7c4jh842ij

    4. Dalmadorm

    5. Dalmane

    6. Felison

    7. Linzac

    8. Natam

    9. Insumin Dihydrochloride

    10. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3h-1,4-benzodiazepin-2-one;hydrochloride

    11. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Monohydrochloride

    12. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride

    13. 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride

    14. Id 480

    15. Einecs 252-867-1

    16. Unii-7c4jh842ij

    17. Fluzepam

    18. Dalmate (tn)

    19. Fluorazepam Hydrochloride

    20. Schembl29794

    21. Chebi:31626

    22. Flurazepam Hydrochloride (jp17)

    23. Dtxsid40189686

    24. Nsc78559

    25. Flurazepam Monohydrochloride [mart.]

    26. D01408

    27. Flurazepam Monohydrochloride [ep Monograph]

    28. Q27268050

    29. Wln: T67 Gnv Jn Ihj Cg G2n2&2 Kr Bf &gh 2

    30. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-, Dihydrochloride

    31. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-, Dihydrochloride

    32. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-,1,3-dihydro-, Dihydrochloride

    33. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Hydrochloride (1:1)

    34. 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,4-benzodiazepin-2-one Dihydrochloride

    35. Flurazepam Monohydrochloride; 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride; 2h-1,4-benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-,1,3-dihydro-, Dihydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 424.3 g/mol
    Molecular Formula C21H24Cl2FN3O
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count6
    Exact Mass423.1280459 g/mol
    Monoisotopic Mass423.1280459 g/mol
    Topological Polar Surface Area35.9 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity540
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFlurazepam hydrochloride
    Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
    Active IngredientFlurazepam hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength30mg; 15mg
    Market StatusPrescription
    CompanyMylan Pharms

    2 of 2  
    Drug NameFlurazepam hydrochloride
    Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
    Active IngredientFlurazepam hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength30mg; 15mg
    Market StatusPrescription
    CompanyMylan Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    GABA Modulators

    Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    Hypnotics and Sedatives

    Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

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