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    Technical details about Fluorodopa F 18, learn more about the structure, uses, toxicity, action, side effects and more

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    Fluorodopa F 18

    APIs // Active Pharmaceutical Ingredients

    DOSSIERs // Finished Dosage Forms

    PATENTS

    PharmaCompass

    Inke S.A: APIs manufacturing plant.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    1. Also known as: Fluorodopa f 18, Fluorodopa f18, Fluorodopa f-18, 92812-82-3, 18f-dopa, L-6-(18f)fluoro-dopa
    Molecular Formula
    C9H10FNO4
    Molecular Weight
    214.18  g/mol
    InChI Key
    PAXWQORCRCBOCU-RPDRGXCHSA-N
    FDA UNII
    2C598205QX
    Fluorodopa F 18 is the amino acid analog fluorodopa (FDOPA) labeled with fluorine F 18, a positron-emitting isotope, with potential tumor tracer property. Fluorine F 18 fluorodopa is able to cross the blood-brain barrier and is taken up by brain tumor cells. As uptake is higher in tumor cells, tumors may then be imaged using positron emission tomography (PET). Assessing tumor uptake of FDOPA may be beneficial for diagnosis, localization and in determining further treatment.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-2-amino-3-(2-(18F)fluoranyl-4,5-dihydroxyphenyl)propanoic acid
    2.1.2 InChI
    InChI=1S/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1/i10-1
    2.1.3 InChI Key
    PAXWQORCRCBOCU-RPDRGXCHSA-N
    2.1.4 Canonical SMILES
    C1=C(C(=CC(=C1O)O)F)CC(C(=O)O)N
    2.1.5 Isomeric SMILES
    C1=C(C(=CC(=C1O)O)[18F])C[C@@H](C(=O)O)N
    2.2 Other Identifiers
    2.2.1 UNII
    2C598205QX
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (18)f-dopa

    2. 18f-fdopa

    3. 2-fluoro-5-hydroxytyrosine

    4. 3,4-dihydroxy-6-fluorophenylalanine

    5. 3-(2-fluoro-(18)f-4,5-dihydroxyphenyl)-l-alanine

    6. 6-(18f)fluoro-l-3,4-dihydroxyphenylalanine

    7. 6-(18f)fluoro-l-dopa

    8. 6-fluoro-dopa

    9. 6-fluorodopa

    10. Fluorodopa

    11. Fluorodopa F 18

    12. Fluorodopa F 18, (18)f-labeled Cpd

    13. Fluorodopa F-18

    2.3.2 Depositor-Supplied Synonyms

    1. Fluorodopa F 18

    2. Fluorodopa F18

    3. Fluorodopa F-18

    4. 92812-82-3

    5. 18f-dopa

    6. L-6-(18f)fluoro-dopa

    7. Fluorine-18-fluoro-l-dopa

    8. 18f-l-fluoro-dopa

    9. Fdopa F-18

    10. Fluorodopa (18f) [inn]

    11. Chebi:49166

    12. 2c598205qx

    13. L-tyrosine, 2-(fluoro-18f)-5-hydroxy-

    14. (s)-2-amino-3-(2-(fluoro-18f)-4,5-dihydroxyphenyl)propanoic Acid

    15. Fluorodopa F 18 (usan)

    16. Fluorodopa F 18 [usan]

    17. F-dopa

    18. (18f)fdopa

    19. 6-(18f)fluoro-l-dopa

    20. 2-(fluoro-18f)-l-dopa

    21. Unii-2c598205qx

    22. Fluorodopa-f-18

    23. Fluorodopa F 18 [usan:usp:inn]

    24. 2-(fluoro-18f)-5-hydroxy-l-tyrosine

    25. Fluorodopa ((18)f)

    26. Fluorodopa F18 (tn)

    27. Schembl522323

    28. Fluorodopa F18 [mi]

    29. ((18)f)fdopa

    30. 6-((18)f)fluoro-l-dopa

    31. Chembl3400972

    32. L-6-((18)f)fluoro-dopa

    33. Dtxsid60239157

    34. Moli000246

    35. Moli000965

    36. Fluorodopa (18f) [who-dd]

    37. Db13848

    38. Fluorodopa F-18 [orange Book]

    39. 18f-fluoro-dihydroxyphenylalanine

    40. Fluorodopa F 18 [usp Impurity]

    41. 2-((18)f)fluoro-5-hydroxy-l-tyrosine

    42. 2-(fluoro-(18)f)-5-hydroxy-l-tyrosine

    43. D04220

    44. L-tyrosine, 2-(fluoro-(sup 18)f)-5-hydroxy-

    45. 6-((18)f)fluoro-3,4-dihydroxy-l-phenylalanine

    46. L-3,4-dihydroxy-6-(18f)fluorophenylalanine

    47. 3-(2-fluoro-(18)f-4,5-dihydroxyphenyl)-l-alanine

    48. 6-fluoro-(18f)-l-3,4-dihydroxyphenylalanine

    49. Q27121509

    50. (18f)-6-fluoro-l,3,4, Dihydroxyphenylalanine

    51. 3-(2-fluoro-(sup 18)f-4,5-dihydroxyphenyl)-l-alanine

    52. (2s)-2-amino-3-(2-(18f)fluoranyl-4,5-dihydroxyphenyl)propanoic Acid

    53. (2s)-2-amino-3-[2-((18)f)fluoro-4,5-dihydroxyphenyl]propanoic Acid

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 214.18 g/mol
    Molecular Formula C9H10FNO4
    XLogP3-2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count3
    Exact Mass214.061920 g/mol
    Monoisotopic Mass214.061920 g/mol
    Topological Polar Surface Area104 Ų
    Heavy Atom Count15
    Formal Charge0
    Complexity238
    Isotope Atom Count1
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Fluorodopa F 18 is indicated for use with positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adult patients with suspected Parkinsonian syndromes (PS).

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    V - Various

    V09 - Diagnostic radiopharmaceuticals

    V09I - Tumour detection

    V09IX - Other diagnostic radiopharmaceuticals for tumour detection

    V09IX05 - Fluorodopa (18F)

    5.2 Absorption, Distribution and Excretion

    Route of Elimination

    Approximately 80% of the administered radioactivity is eliminated in the urine.

    Clearance

    The agent is cleared from blood and tissue within 24 hours following administration.

    5.3 Metabolism/Metabolites

    Fluorodopa F 18 is decarboxylated by aromatic amino acid decarboxylase (AADC) in the striatum to fluorodopamine F 18. Fluorodopamine F 18 is then further metabolized by monoamine oxidase (MAO) to yield [18F] 6-fluoro-3,4-dihydroxyphenylacetic acid, then subsequently by COMT to yield [18F]6-fluorohomovanillic acid.

    5.4 Biological Half-Life

    The plasma half-life following intravenous administration is approximately 1-3 hours.

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