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Technical details about Esomeprazole Magnesium, learn more about the structure, uses, toxicity, action, side effects and more

Esomeprazole Magnesium

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

132 Suppliers, 63 USDMF, 48 CEP/COS, 6 JDMF, 39 EU WC, 79 KDMF, 45 NDC API, 63 Listed Suppliers

DEVELOPMENTS

2 Drug(s) in Development

2 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

15 Suppliers

15 Suppliers

DOSSIERs // Finished Dosage Forms

767 Dossiers, 90 FDA Orange Book, 359 Europe, 23 Canada, 86 Australia, 52 South Africa, 157 Listed Dossiers

DRUG PRODUCT COMPOSITION

CAPSULE, DELAYED RELEASE;ORAL - EQ 20MG BASE, CAPSULE, DELAYED REL PELLETS;ORAL - EQ 20MG BASE, CAPSULE, DELAYED REL PELLETS;ORAL - EQ 40MG BASE, FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 2.5MG BASE/PACKET, FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 20MG BASE/PACKET, FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 40MG BASE/PACKET, FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 5MG BASE/PACKET, TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE;375MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE;500MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers, 30 BASF, 19 Kerry, 18 Roquette, 17 SPI Pharma, 15 Corel Pharma Chem, 14 Seppic, 13 Ideal Cures Pvt Ltd, 11 Microlex e.U, 11 Gangwal Chemicals, 10 Sigachi Industries, 10 Gangwal Healthcare, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Actylis, 6 Lonza Capsugel, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 4 Prachin Chemical, 4 ACG Worldwide, 4 Ingredion Pharma Solutions, 4 Nanjing Well Pharmaceutical, 4 Kima Chemical, 3 The Dow Chemical Company, 3 Vasa Pharmachem, 3 Jai Radhe Sales, 3 Doshion Polyscience, 3 Pharmatrans-Sanaq, 3 DKSH, 3 Boai NKY Pharmaceuticals Ltd, 3 DFE Pharma, 2 Qualicaps, 2 Evonik, 2 Alcedo Pharmachem, 2 Pfanstiehl, 2 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Ulanqab Kema New Material, 2 Seqens, 2 Finar, 1 Aeon Procare, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 NEWEDGE Overseas, 1 Chynops Pharma, 1 Rochem International Inc, 1 Minakem, 1 Vertellus

EXCIPIENTS BY APPLICATIONS

68 Coating Systems & Additives, 64 Fillers, Diluents & Binders, 43 Controlled & Modified Release, 34 Direct Compression, 29 Solubilizers, 26 Taste Masking, 26 Thickeners and Stabilizers, 24 Disintegrants & Superdisintegrants, 24 Granulation, 20 Lubricants & Glidants, 17 Chewable & Orodispersible Aids, 16 Film Formers & Plasticizers, 16 Co-Processed Excipients, 15 Topical, 14 Parenteral, 9 Empty Capsules, 6 API Stability Enhancers, 6 Emulsifying Agents, 4 Vegetarian Capsules, 4 Rheology Modifiers, 3 Surfactant & Foaming Agents, 2 Coloring Agents

GLOBAL SALES INFORMATION

23 US Medicaid Prescriptions, 290 Finished Drug Prices

MARKET PLACE

64 APIs, 35 DOSSIERS // FDF

PATENTS

2 US Patents, 44 Health Canada Patents

ANALYTICAL SOLUTION(s)

2 BioAnalytical Methods, 5 EDQM Standards, 1 USP Standards, 21 Other Ref. Standards

DIGITAL CONTENT

15 Data Compilation & Company Tracker #PharmaFlow, 149 News

Also known as: Omeprazole magnesium, 161973-10-0, Prilosec otc, H 168/68 magnesium, 95382-33-5, Omeprazole (as magnesium)

Molecular Formula

C₃₄H₃₆MgN₆O₆S₂

Molecular Weight

713.1 g/mol

InChI Key

KWORUUGOSLYAGD-UHFFFAOYSA-N

FDA UNII

426QFE7XLK

The S-isomer of omeprazole.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

2.1.2 InChI

InChI=1S/2C17H18N3O3S.Mg/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h2*5-8H,9H2,1-4H3;/q2*-1;+2

2.1.3 InChI Key

KWORUUGOSLYAGD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]

2.2 Other Identifiers

2.2.1 UNII

426QFE7XLK

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Esomeprazole

2. Esomeprazole Potassium

3. Esomeprazole Sodium

4. Esomeprazole Strontium

5. Esomeprazole Strontium Anhydrous

6. Nexium

7. Strontium, Esomeprazole

2.3.2 Depositor-Supplied Synonyms

1. Omeprazole Magnesium

2. 161973-10-0

3. Prilosec Otc

4. H 168/68 Magnesium

5. 95382-33-5

6. Omeprazole (as Magnesium)

7. 426qfe7xlk

8. Magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

9. Esomeprazole Magnesium Salt

10. Unii-426qfe7xlk

11. Omeprazole Magnesium [usan]

12. Omeprazole Magnesium [usan:usp]

13. Prilosec Otc (tn)

14. Esomeprazole(magnesium)

15. Omeprazole Magnesium Salt

16. Omeprazole Magnesium (usp)

17. Mls001165732

18. Schembl722792

19. Esomeprazole Magnesium (nexium)

20. Chembl1567328

21. Chebi:94401

22. H-168/68 Magnesium

23. Hms2878h13

24. Omeprazole Magnesium [vandf]

25. Mfcd06798050

26. Omeprazole Magnesium [mart.]

27. Omeprazole Magnesium [usp-rs]

28. Omeprazole Magnesium [who-dd]

29. Akos015896379

30. Akos025402081

31. Omeprazole Magnesium Salt [mi]

32. As-75082

33. Omeprazole Magnesium [orange Book]

34. Smr000550477

35. Omeprazole Magnesium [ep Monograph]

36. Omeprazole Magnesium [usp Impurity]

37. Omeprazole Magnesium [usp Monograph]

38. Ft-0657297

39. Sw220306-1

40. Talicia Component Omeprazole Magnesium

41. D05259

42. Omeprazole Magnesium Component Of Talicia

43. A810316

44. J-014249

45. Q-100195

46. Q27166253

47. 5-methoxy-1h-1,3-benzimidazol-2-yl (4-methoxy-3,5-dimethyl-2-pyridinyl)methyl Sulfoxide

48. (rs)-5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole, Magnesium Salt (2:1)

49. 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole, Magnesium Salt

50. 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole, Magnesium Salt (2:1)

51. Magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]benzimidazol-1-ide;esomeprazole Magnesium(random Configuration)

52. Magnesium(2+) 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1h-1,3-benzodiazol-1-ide 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1h-1,3-benzodiazol-1-ide

53. Magnesium, Bis(6-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl-.kappa.o)-1h-benzimidazolato-.kappa.n3)-, (t-4)-

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₃₆MgN₆O₆S₂
Molecular Weight	713.1 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	10
Exact Mass	712.1988169 g/mol
Monoisotopic Mass	712.1988169 g/mol
Topological Polar Surface Area	163 Å²
Heavy Atom Count	49
Formal Charge	0
Complexity	453
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Esomeprazole magnesium
PubMed Health	Esomeprazole
Drug Classes	Gastric Acid Secretion Inhibitor, Gastrointestinal Agent
Drug Label	The active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active Ingredient	Esomeprazole magnesium
Dosage Form	Capsule, delayed release
Route	oral
Strength	40mg; 20mg
Market Status	Tentative Approval
Company	Ranbaxy

2 of 6
Drug Name	Nexium
Drug Label	The active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active Ingredient	Esomeprazole magnesium
Dosage Form	Capsule, delayed rel pellets; For suspension, delayed release
Route	Oral
Strength	eq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
Market Status	Prescription
Company	Astrazeneca

3 of 6
Drug Name	Omeprazole magnesium
Drug Label	The active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active Ingredient	Omeprazole magnesium
Dosage Form	Capsule, delayed release
Route	Oral
Strength	eq 20mg base
Market Status	Over the Counter
Company	Dr Reddys Labs

4 of 6
Drug Name	Esomeprazole magnesium
PubMed Health	Esomeprazole
Drug Classes	Gastric Acid Secretion Inhibitor, Gastrointestinal Agent
Drug Label	The active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active Ingredient	Esomeprazole magnesium
Dosage Form	Capsule, delayed release
Route	oral
Strength	40mg; 20mg
Market Status	Tentative Approval
Company	Ranbaxy

5 of 6
Drug Name	Nexium
Drug Label	The active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active Ingredient	Esomeprazole magnesium
Dosage Form	Capsule, delayed rel pellets; For suspension, delayed release
Route	Oral
Strength	eq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
Market Status	Prescription
Company	Astrazeneca

6 of 6
Drug Name	Omeprazole magnesium
Drug Label	The active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active Ingredient	Omeprazole magnesium
Dosage Form	Capsule, delayed release
Route	Oral
Strength	eq 20mg base
Market Status	Over the Counter
Company	Dr Reddys Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Proton Pump Inhibitor [EPC]; Proton Pump Inhibitors [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]

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