loader
Please Wait
Applying Filters...
Close
4

Suanfarma Suanfarma

X
menu

    Market Place

    Market Place

    Post Enquiry

    Post Enquiry
    menu

    Technical details about Ergotidine, learn more about the structure, uses, toxicity, action, side effects and more

    Client Email Product
    Menu

    Ergotidine

    APIs // Active Pharmaceutical Ingredients

    DEVELOPMENTS

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    DIGITAL CONTENT

    PharmaCompass

    PharmaCompass Sponsored Ads

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    1. Also known as: 56-92-8, Histamine 2hcl, Ceplene, Peremin, 1h-imidazole-4-ethanamine dihydrochloride, 2-(1h-imidazol-4-yl)ethanamine dihydrochloride
    Molecular Formula
    C5H11Cl2N3
    Molecular Weight
    184.06  g/mol
    InChI Key
    PPZMYIBUHIPZOS-UHFFFAOYSA-N
    FDA UNII
    3POA0Q644U
    An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
    2.1.2 InChI
    InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
    2.1.3 InChI Key
    PPZMYIBUHIPZOS-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=C(NC=N1)CCN.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    3POA0Q644U
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ceplene

    2. Histamine

    3. Histamine Hydrochloride

    4. Peremin

    2.3.2 Depositor-Supplied Synonyms

    1. 56-92-8

    2. Histamine 2hcl

    3. Ceplene

    4. Peremin

    5. 1h-imidazole-4-ethanamine Dihydrochloride

    6. 2-(1h-imidazol-4-yl)ethanamine Dihydrochloride

    7. 1h-imidazole-4-ethanamine, Dihydrochloride

    8. 2-(4-imidazolyl)ethylamine Dihydrochloride

    9. 2-(1h-imidazol-4-yl)ethylamine Dihydrochloride

    10. Histaminedihydrochloride

    11. Mfcd00012703

    12. Histamine Chloride

    13. Histamine Dihcl

    14. Histamine Dichloride

    15. Histamine Dihydrochloride [usan]

    16. 2-imidazol-4-ylethylamine Dihydrochloride

    17. Histaminedium Dichloride

    18. Histamine Hcl

    19. 4-(2-aminoethyl)imidazole Dihydrochloride

    20. Histamine Dichlorhydrate

    21. Histaminum Hydrochloricum

    22. 2-(1h-imidazol-5-yl)ethanamine Dihydrochloride

    23. Histamine (dihydrochloride)

    24. 2-(1h-imidazol-4-yl)ethan-1-amine Dihydrochloride

    25. Histamine, Dihydrochloride

    26. 3poa0q644u

    27. Nsc-257873

    28. 1h-imidazole-5-ethanamine, Hydrochloride (1:2)

    29. Bichlorhydrated'histamine

    30. Histamine Dihydrochloride (usan)

    31. 2-(1h-imidazol-4-yl)ethanamine;dihydrochloride

    32. Sr-01000075270

    33. Bichlorhydrate D'histamine [french]

    34. Einecs 200-298-4

    35. Bichlorhydrate D'histamine

    36. Nsc 257873

    37. Unii-3poa0q644u

    38. Ai3-24394

    39. Ceplene (tn)

    40. Histamine Dihydrocloride

    41. 2-(1h-imidazol-5-yl)ethanamine;dihydrochloride

    42. C5h9n3.2hcl

    43. Schembl58710

    44. Spectrum1500331

    45. Chembl1533310

    46. Dtxsid1058767

    47. Schembl16778301

    48. Timtec-bb Sbb003722

    49. Hms1920d11

    50. Act02743

    51. Bcp16313

    52. Hy-b0722

    53. Str02021

    54. Tox21_500595

    55. Ccg-38567

    56. Mfcd08060928

    57. S4118

    58. Histamine Dihydrochloride [mi]

    59. Akos015894236

    60. Akos016353223

    61. Ac-7507

    62. Bs-3141

    63. Cs-w020699

    64. Histamine Hydrochloride [mart.]

    65. Ks-5310

    66. Lp00595

    67. Histamine Hydrochloride [who-dd]

    68. Histaminum Hydrochloricum [hpus]

    69. Ncgc00093973-01

    70. Ncgc00093973-02

    71. Ncgc00093973-03

    72. Ncgc00261280-01

    73. 2-(4-imidazolyl)ethylaminedihydrochloride

    74. 4-(2-aminoethyl)imidazole Dihydorchloride

    75. Bp-12001

    76. Histamine Dihydrochloride [usp-rs]

    77. Sy012860

    78. Db-019204

    79. Histamine Dihydrochloride [ema Epar]

    80. Histamine Dihydrochloride, >=99.0% (at)

    81. Eu-0100595

    82. Ft-0627074

    83. H0146

    84. Sw219552-1

    85. En300-75558

    86. 4-(2-aminoethyl)-1h-imidazole Dihydrochloride

    87. D04444

    88. Edihydrochlorideavailablefrom1kgto100kg.

    89. H 7250

    90. H-2250

    91. H-2255

    92. Histamine Dihydrochloride [ep Monograph]

    93. 012h703

    94. A831236

    95. Histamine Dihydrochloride, >=99% (tlc), Powder

    96. 1h-imidazole-4-ethanamine, Chloride (1:1)

    97. 2-(1h-imidazol-5-yl)ethan-1-amine Dihydrochloride

    98. Q5772985

    99. Sr-01000075270-1

    100. Sr-01000075270-7

    101. Histamine Dihydrochloride, Tested According To Ph Eur

    102. F2191-0277

    103. Histamine Dihydrochloride, Saj Special Grade, >=98.0%

    104. Histamine Dihydrochloride, Vetec(tm) Reagent Grade, 98%

    105. Z1267773750

    106. 2-(1h-imidazol-5-yl)ethanamine Dihydrochloride, Aldrichcpr

    107. 2-(1h-imidazol-5-yl)ethanamine Hydrochloride (1:1)

    108. Histamine Dihydrochloride 100 Microg/ml In Acetonitrile:water

    109. Histamine Dihydrochloride, European Pharmacopoeia (ep) Reference Standard

    110. Allergen Scratch Extract Positive Control 'torii' Histamine Dihydrochloride

    111. Histamine Dihydrochloride, United States Pharmacopeia (usp) Reference Standard

    112. 2-(4-imidazolyl)ethylamine Dihydrochloride; 2-(1h-imidazol-4-yl)ethylamine Dihydrochloride;histamine 2hcl

    2.3.3 Other Synonyms

    1. Ergamine

    2. Ergotidine

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 184.06 g/mol
    Molecular Formula C5H11Cl2N3
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass183.0330028 g/mol
    Monoisotopic Mass183.0330028 g/mol
    Topological Polar Surface Area54.7 Ų
    Heavy Atom Count10
    Formal Charge0
    Complexity64.7
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Ceplene maintenance therapy is indicated for adult patients with acute myeloid leukaemia in first remission concomitantly treated with interleukin-2 (IL-2). The efficacy of Ceplene has not been fully demonstrated in patients older than age 60.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine Agonists

    Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety of clinical applications histamine agonists have so far been more widely used in research than therapeutically. (See all compounds classified as Histamine Agonists.)

    5.2 ATC Code

    L03AX14

    L - Antineoplastic and immunomodulating agents

    L03 - Immunostimulants

    L03A - Immunostimulants

    L03AX - Other immunostimulants

    L03AX14 - Histamine dihydrochloride

    Post Enquiry
    POST ENQUIRY