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    Edurant / Truvada

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

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    2D Structure
    Also known as: Edurant / truvada, Emtricitabine / rilpivirine /tenofovir disoproxil, Emtricitabine mixture with rilpivirine hydrochloride and tenofovir disoproxil fumarate, 847446-10-0
    Molecular Formula
    C53H63ClFN14O17PS
    Molecular Weight
    1285.6  g/mol
    InChI Key
    NEZNLHNPLRCSOG-FNZDRVHOSA-N
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(E)-but-2-enedioic acid;4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile;hydrochloride
    2.1.2 InChI
    InChI=1S/C22H18N6.C19H30N5O10P.C8H10FN3O3S.C4H4O4.ClH/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19;1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5;5-3(6)1-2-4(7)8;/h3-9,11-13H,1-2H3,(H2,25,26,27,28);7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1,5-6,13H,2-3H2,(H2,10,11,14);1-2H,(H,5,6)(H,7,8);1H/b4-3+;;;2-1+;/t;14-;5-,6+;;/m.10../s1
    2.1.3 InChI Key
    NEZNLHNPLRCSOG-FNZDRVHOSA-N
    2.1.4 Canonical SMILES
    CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C=CC#N.CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F.C(=CC(=O)O)C(=O)O.Cl
    2.1.5 Isomeric SMILES
    CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N.C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.C1[C@H](O[C@H](S1)CO)N2C=C(C(=NC2=O)N)F.C(=C/C(=O)O)\C(=O)O.Cl
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. Edurant / Truvada

    2. Emtricitabine / Rilpivirine /tenofovir Disoproxil

    3. Emtricitabine Mixture With Rilpivirine Hydrochloride And Tenofovir Disoproxil Fumarate

    4. 847446-10-0

    2.3 Create Date
    2012-03-21
    3 Chemical and Physical Properties
    Molecular Weight 1285.6 g/mol
    Molecular Formula C53H63ClFN14O17PS
    Hydrogen Bond Donor Count8
    Hydrogen Bond Acceptor Count29
    Rotatable Bond Count26
    Exact Mass1284.3626506 g/mol
    Monoisotopic Mass1284.3626506 g/mol
    Topological Polar Surface Area471 Ų
    Heavy Atom Count88
    Formal Charge0
    Complexity1800
    Isotope Atom Count0
    Defined Atom Stereocenter Count3
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count2
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count5
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameComplera
    PubMed HealthEmtricitabine/Rilpivirine/Tenofovir (By mouth)
    Drug ClassesAntiretroviral Agent
    Drug LabelCOMPLERA is a fixed-dose combination tablet containing emtricitabine, rilpivirine hydrochloride, and tenofovir DF. EMTRIVA is the brand name for emtricitabine, a synthetic nucleoside analog of cytidine. EDURANT is the brand name for rilpivirine, a no...
    Active Ingredienttenofovir disoproxil fumarate; rilpivirine hydrochloride; Emtricitabine
    Dosage FormTablet
    RouteOral
    Strength300mg; 200mg; eq 25mg base
    Market StatusPrescription
    CompanyGilead Sciences

    2 of 2  
    Drug NameComplera
    PubMed HealthEmtricitabine/Rilpivirine/Tenofovir (By mouth)
    Drug ClassesAntiretroviral Agent
    Drug LabelCOMPLERA is a fixed-dose combination tablet containing emtricitabine, rilpivirine hydrochloride, and tenofovir DF. EMTRIVA is the brand name for emtricitabine, a synthetic nucleoside analog of cytidine. EDURANT is the brand name for rilpivirine, a no...
    Active Ingredienttenofovir disoproxil fumarate; rilpivirine hydrochloride; Emtricitabine
    Dosage FormTablet
    RouteOral
    Strength300mg; 200mg; eq 25mg base
    Market StatusPrescription
    CompanyGilead Sciences