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    Technical details about DSSTox_CID_3665, learn more about the structure, uses, toxicity, action, side effects and more

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    DSSTox_CID_3665

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

    MARKET PLACE

    ANALYTICAL SOLUTION(s)

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 33005-95-7, Surgam, Tiaprofensaeure, 2-(5-benzoylthiophen-2-yl)propanoic acid, Acido tiaprofenico, Acide tiaprofenique
    Molecular Formula
    C14H12O3S
    Molecular Weight
    260.31  g/mol
    InChI Key
    GUHPRPJDBZHYCJ-UHFFFAOYSA-N
    FDA UNII
    1LS1T6R34C
    Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(5-benzoylthiophen-2-yl)propanoic acid
    2.1.2 InChI
    InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
    2.1.3 InChI Key
    GUHPRPJDBZHYCJ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C1=CC=C(S1)C(=O)C2=CC=CC=C2)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    1LS1T6R34C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apo-tiaprofenic

    2. Fc 3001

    3. Flanid

    4. Novo-tiaprofenic

    5. Nu-tiaprofenic

    6. Pms-tiaprofenic

    7. Ru 15060

    8. Surgam

    9. Surgam Sa

    10. Tiaprofenic Acid, Calcium Salt

    2.3.2 Depositor-Supplied Synonyms

    1. 33005-95-7

    2. Surgam

    3. Tiaprofensaeure

    4. 2-(5-benzoylthiophen-2-yl)propanoic Acid

    5. Acido Tiaprofenico

    6. Acide Tiaprofenique

    7. Acidum Tiaprofenicum

    8. 5-benzoyl-alpha-methyl-2-thiopheneacetic Acid

    9. 2-(5-benzyl-2-thienyl)propionsaeure

    10. Tiaprofen

    11. Acide Tiaprofenique [inn-french]

    12. Acido Tiaprofenico [inn-spanish]

    13. Acidum Tiaprofenicum [inn-latin]

    14. Ru 15060

    15. 2-[5-(phenylcarbonyl)-2-thienyl]propanoic Acid

    16. Fc 3001

    17. Tiaprofenate

    18. Suralgan

    19. Alpha-methyl-5-benzoyl-2-thienylacetic Acid

    20. Chebi:32221

    21. 5-benzoyl-alpha-methylthiophene-2-acetic Acid

    22. 2-(5-benzoyl-2-thienyl)propanoic Acid

    23. 1ls1t6r34c

    24. Ru-15060

    25. 2-(5-benzoyl-thiophen-2-yl)-propionic Acid

    26. Dsstox_cid_3665

    27. 5-benzoyl-.alpha.-methyl-2-thiopheneacetic Acid

    28. Dsstox_rid_77134

    29. Dsstox_gsid_23665

    30. Surgam Sa

    31. Einecs 251-329-3

    32. Brn 1380662

    33. Unii-1ls1t6r34c

    34. Ncgc00016815-01

    35. Prestwick_814

    36. Cas-33005-95-7

    37. 2-(5-benzoylthiophen-2-yl)propanoicacid

    38. Prestwick0_000496

    39. Prestwick1_000496

    40. Prestwick2_000496

    41. Prestwick3_000496

    42. Epitope Id:131796

    43. 2-thiopheneacetic Acid, 5-benzoyl-alpha-methyl-

    44. Schembl25639

    45. Bspbio_000391

    46. 2-thiopheneacetic Acid, 5-benzoyl-.alpha.-methyl-

    47. 5-18-08-00405 (beilstein Handbook Reference)

    48. Mls002153845

    49. Tiaprofenic Acid [mi]

    50. Spbio_002312

    51. Tiaprofenic Acid [inn]

    52. Tiaprofenic Acid [jan]

    53. Bpbio1_000431

    54. Chembl365795

    55. Dtxsid5023665

    56. Tiaprofenic Acid [mart.]

    57. Tiaprofenic Acid [who-dd]

    58. Bdbm223313

    59. Hms1569d13

    60. Hms2096d13

    61. Hms2230e19

    62. Hms3372d06

    63. Hms3713d13

    64. Amy17789

    65. Ex-a4101

    66. Tox21_110627

    67. Mfcd00866089

    68. S5661

    69. Stl454339

    70. (5-benzoyl-2-thienyl)-propionic Acid

    71. Akos015969058

    72. Tiaprofenic Acid [ep Impurity]

    73. Tox21_110627_1

    74. Ac-8970

    75. Ccg-220496

    76. Db01600

    77. Tiaprofenic Acid [ep Monograph]

    78. Ncgc00179573-03

    79. As-77449

    80. Smr001233207

    81. 2-(5-benzoyl-2-thienyl)propanoic Acid #

    82. 2-(5-benzoylthiophen-2-yl)propionic Acid

    83. Alpha-(5-benzoyl-2-thienyl)propionic Acid

    84. 5-benzoyl-

    85. A-methyl-2-thiopheneacetic Acid

    86. Hy-106579

    87. Cs-0026096

    88. Ft-0675220

    89. T3175

    90. D01325

    91. 005t957

    92. Q419926

    93. Sr-01000841193

    94. 2-(5-benzoyl-2-thienyl)propanoic Acid, Aldrichcpr

    95. 2-[5-(phenylcarbonyl)thiophen-2-yl]propanoic Acid

    96. J-018971

    97. Sr-01000841193-2

    98. Brd-a72988804-001-03-8

    99. Ethyl( Inverted Exclamation Marka)-1-[1-(4-fluorophenyl)ethyl]-1h-imidazole-4-carboxylate

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 260.31 g/mol
    Molecular Formula C14H12O3S
    XLogP33.3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass260.05071541 g/mol
    Monoisotopic Mass260.05071541 g/mol
    Topological Polar Surface Area82.6 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity323
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Tiaprofenic acid is used to treat pain, especially arthritic pain.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300mg twice daily. This drug is not recommended for use in the pediatric population.

    5.2 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    5.3 ATC Code

    M - Musculo-skeletal system

    M01 - Antiinflammatory and antirheumatic products

    M01A - Antiinflammatory and antirheumatic products, non-steroids

    M01AE - Propionic acid derivatives

    M01AE11 - Tiaprofenic acid

    5.4 Absorption, Distribution and Excretion

    Absorption

    Bioavailability is 90% following oral administration.

    5.5 Metabolism/Metabolites

    Hepatic (10%). Sparingly metabolised in the liver to two inactive metabolites.

    5.6 Biological Half-Life

    1.5-2.5 hours

    5.7 Mechanism of Action

    Tiaprofenic acid belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a chemical (prostaglandin) which the body produces in response to injury or certain diseases. This prostaglandin would otherwise go on to cause swelling, pain and inflammation.

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