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Technical details about DSSTox_CID_29375, learn more about the structure, uses, toxicity, action, side effects and more

DSSTox_CID_29375

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

16 Suppliers, 4 USDMF, 6 CEP/COS, 2 JDMF, 3 EU WC, 2 KDMF, 12 NDC API, 13 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

DOSSIERs // Finished Dosage Forms

101 Dossiers, 30 FDA Orange Book, 38 Europe, 32 Canada, 1 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - 0.25%, INJECTABLE;INJECTION - 0.25%;0.0091MG/ML, INJECTABLE;INJECTION - 0.5%, INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - 0.75%, INJECTABLE;INJECTION - 0.75%;0.0091MG/ML, INJECTABLE;INJECTION - 0.25%, INJECTABLE;INJECTION - 0.5%, INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - 0.75%, INJECTABLE;INJECTION - 0.75%;0.0091MG/ML, INJECTABLE;INJECTION - 4%; EQ 0.0085MG BASE/1.7ML (4%; EQ 0.005MG BASE/ML), INJECTABLE;INJECTION - 4%;EQ 0.017MG BASE/1.7ML (4%;EQ 0.01MG BASE/ML), INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - EQ 0.02MG BASE/ML;2%, INJECTABLE;INJECTION - EQ 0.01MG BASE/ML;2%

RELATED EXCIPIENT COMPANIES

Suppliers, 4 Actylis, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl

GLOBAL SALES INFORMATION

26 Finished Drug Prices

26 Finished Drug Prices

MARKET PLACE

24 APIs, 3 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

6 EDQM Standards, 1 USP Standards, 2 JP Standards, 1 Other Ref. Standards

DIGITAL CONTENT

9 News

9 News

DSSTox_CID_29375
Chemistry
Full Screen View

Also known as: (-)-epinephrine bitartrate, Adrenaline bitartrate, Mls000028381, Epinephrine d-bitartrate, L-epinephrine bitartrate, Smr000058630

Molecular Formula

C₁₃H₁₉NO₉

Molecular Weight

333.29 g/mol

InChI Key

YLXIPWWIOISBDD-FVGYRXGTSA-N

The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,3-dihydroxybutanedioic acid;4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

2.1.2 InChI

InChI=1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;/m0./s1

2.1.3 InChI Key

YLXIPWWIOISBDD-FVGYRXGTSA-N

2.1.4 Canonical SMILES

CNCC(C1=CC(=C(C=C1)O)O)O.C(C(C(=O)O)O)(C(=O)O)O

2.1.5 Isomeric SMILES

CNC[C@@H](C1=CC(=C(C=C1)O)O)O.C(C(C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

2. Acetate, Epinephrine

3. Adrenaline

4. Adrenaline Acid Tartrate

5. Adrenaline Bitartrate

6. Adrenaline Hydrochloride

7. Epifrin

8. Epinephrine

9. Epinephrine Acetate

10. Epinephrine Bitartrate

11. Epinephrine Hydrochloride

12. Epitrate

13. Lyophrin

14. Medihaler-epi

2.2.2 Depositor-Supplied Synonyms

1. (-)-epinephrine Bitartrate

2. Adrenaline Bitartrate

3. Mls000028381

4. Epinephrine D-bitartrate

5. L-epinephrine Bitartrate

6. Smr000058630

7. Adrenaline Bitartate

8. Adrenaline (as Tartrate)

9. Sr-01000075267

10. L-epinephrine Hydrogen Tartrate

11. Adrenalin Tartrate

12. Nsc-756755

13. Opera_id_1462

14. Epinephrini Hydrogenotartras

15. Lopac0_000502

16. Schembl597216

17. Chembl1256958

18. L-adrenaline Hydrogen Bitartrate

19. L-epinephrine Hydrogen Bitartrate

20. Hms2233k16

21. Hms3261f05

22. Tox21_500502

23. Akos030504417

24. Ccg-221806

25. Lp00502

26. Ncgc00093902-01

27. Ncgc00261187-01

28. A0175

29. Eu-0100502

30. E 4375

31. Sr-01000075267-1

32. Sr-01000075267-4

33. Sr-01000075267-6

2.3 Create Date

2006-06-15

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₉NO₉
Molecular Weight	333.29 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	333.10598118 g/mol
Monoisotopic Mass	333.10598118 g/mol
Topological Polar Surface Area	188 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	288
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

Adrenergic beta-Agonists

Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)

Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

Mydriatics

Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

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