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    Dothiepin Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

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    $ API Ref.Price (USD/KG) : 234Xls

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    2D Structure
    Also known as: Dothiepin hcl, Depresym, Dosulepin hydrochloride, 897-15-4, Dopress, Dosulepine
    Molecular Formula
    C19H22ClNS
    Molecular Weight
    331.9  g/mol
    InChI Key
    XUPZAARQDNSRJB-SJDTYFKWSA-N
    FDA UNII
    3H0042311V
    A tricyclic antidepressant with some tranquilizing action.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3E)-3-(6H-benzo[c][1]benzothiepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
    2.1.3 InChI Key
    XUPZAARQDNSRJB-SJDTYFKWSA-N
    2.1.4 Canonical SMILES
    CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31.Cl
    2.1.5 Isomeric SMILES
    CN(C)CC/C=C/1\C2=CC=CC=C2CSC3=CC=CC=C31.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    3H0042311V
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dosulepin

    2. Dothiepin

    3. Hydrochloride, Dothiepin

    4. Prothiaden

    2.3.2 Depositor-Supplied Synonyms

    1. Dothiepin Hcl

    2. Depresym

    3. Dosulepin Hydrochloride

    4. 897-15-4

    5. Dopress

    6. Dosulepine

    7. Prothiadene

    8. Dothep

    9. Dothiepin Hydrochloride [usan]

    10. Prothiaden

    11. Nsc-172130

    12. Dosulepin Chloride

    13. Prothiadiene

    14. 3h0042311v

    15. 1-propanamine, 3-dibenzo(b,e)thiepin-11(6h)-ylidene-n,n-dimethyl-, Hydrochloride

    16. Prothiaden Hydrochloride

    17. Prothiadene Hydrochloride

    18. Xerenal

    19. Trans-dothiepin Hydrochloride

    20. Idom

    21. Chebi:36805

    22. Trans-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin Hydrochloride

    23. Thaden

    24. Dosulepin Hydrochloride [jan]

    25. (3e)-3-(6h-benzo[c][1]benzothiepin-11-ylidene)-n,n-dimethylpropan-1-amine;hydrochloride

    26. Unii-3h0042311v

    27. Einecs 212-978-8

    28. Dothiepinhcl

    29. Nsc 172130

    30. Nsc172130

    31. Schembl35428

    32. Mls002153839

    33. Dothiepin Hydrochloride- Bio-x

    34. Chembl1711280

    35. Dtxsid60873550

    36. Amy40796

    37. Dothiepin Hydrochloride [mi]

    38. Ccg-220488

    39. Dosulepin Hydrochloride [mart.]

    40. 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepine Hydrochloride

    41. Dibenzo(b,e)thiepin-delta(sup 11(6h),gamma)-propylamine, N,n-dimethyl-, Hydrochloride, (e)-

    42. Dosulepin Hydrochloride [who-dd]

    43. N,n-dimethyldibenzo(b,e)thiepin-delta(sup 11(6h),gamma)-propylamine Hydrochloride

    44. Bd164382

    45. Smr001233202

    46. Dosulepin Hydrochloride [ep Monograph]

    47. Wln: T C676 Is&t&j B3n1&1 &gh

    48. Sr-01000838836

    49. Sr-01000838836-2

    50. Q27116969

    51. 11-[3-(dimethylamino)propylidene]-6,e]thiepin Hydrochloride

    52. 11-[3-(dimethylamino)propylidene]-6,e]thiepine Hydrochloride

    53. Dibenzo[b,.gamma.-propylamine, N,n-dimethyl-, Hydrochloride

    54. N,e]thiepin-.delta.11(6h),.gamma.-propylamine, Hydrochloride

    55. 1-propanamine,e]thiepin-11(6h)-ylidene-n,n-dimethyl-, Hydrochloride

    56. Dibenzo(b,e)thiepin-delta(sup 11(6h),gamma)-propylamine, N,n-dimethyl-, Hydrochloride

    57. Dibenzo(b,e)thiepin-delta11(6h),gamma-propylamine, N,n-dimethyl-, Hydrochloride

    58. Dothiepin Hydrochloride (dosulepin Hydrochloride) 1.0 Mg/ml In Methanol (as Free Base)

    59. (3e)-3-(dibenzo[b,e]thiepin-11(6h)-ylidene)-n,n-dimethylpropan-1-amine, Hydrogen Chloride (1:1)

    60. Dothiepin (cis/trans) Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.3.3 Other Synonyms

    1. Dosulepin Chloride

    2. Dothiepin Hcl

    3. Idom

    4. Prothiaden

    5. Prothiadene

    6. Xerenal

    7. Dosulepin Hydrochloride

    8. Dosulepine

    9. Dosulepin

    10. Dothiepin

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 331.9 g/mol
    Molecular Formula C19H22ClNS
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass331.1161486 g/mol
    Monoisotopic Mass331.1161486 g/mol
    Topological Polar Surface Area28.5 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity363
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic Uptake Inhibitors

    Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)

    Antidepressive Agents, Tricyclic

    Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)