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1. Bichloride, Mercury
2. Chloride, Mercuric
3. Corrosive Sublimate
4. Dichloride, Mercury
5. Hgcl2
6. Mercuric Perchloride
7. Mercury Bichloride
8. Mercury Dichloride
9. Mercury Perchloride
10. Perchloride, Mercuric
11. Perchloride, Mercury
12. Sublimate
13. Sublimate, Corrosive
1. Dichloromercury
2. Mercury(ii) Chloride
3. Sublimate
4. Mercury Bichloride
5. Mercury Dichloride
6. Corrosive Sublimate
7. Mercuric Bichloride
8. Mercury Perchloride
9. 7487-94-7
10. Sublimat
11. Chlorure Mercurique
12. Sulema
13. Hgcl2
14. Corrosive Mercury Chloride
15. Perchloride Of Mercury
16. Calochlor
17. Fungchex
18. Sulem
19. Bichlorure De Mercure
20. Abavit B
21. Bichloride Of Mercury
22. Chlorid Rtutnaty
23. Mercury Chloride (hgcl2)
24. Mercury(2+) Chloride
25. Quecksilber Chlorid
26. Cloruro Di Mercurio
27. Mercury(ii)chloride
28. Dichlorure De Mercure
29. Tl 898
30. Clhgcl
31. Nci-c60173
32. Nsc 353255
33. Hydrargyrum Bichloratum
34. Quecksilber(ii)-chlorid
35. Mercuric Chloride [jan]
36. Mercury Chloride (hgcl(2))
37. Chebi:31823
38. Mfcd00011041
39. Calocure
40. Mercuric Chloride (jan)
41. Sublimat [czech]
42. Sulema [russian]
43. Caswell No. 544
44. Hydraargyrum Bichloratum
45. Chlorid Rtutnaty [czech]
46. Chlorure Mercurique [french]
47. Quecksilber Chlorid [german]
48. Hsdb 33
49. Bichlorure De Mercure [french]
50. Ccris 4838
51. Mercury Chloride (2)
52. Chlorure Mercurique [iso-french]
53. Mercury (ii) Chloride
54. Einecs 231-299-8
55. Un1624
56. Unii-53gh7mzt1r
57. Epa Pesticide Chemical Code 052001
58. Mercuric Chloride [jan:iso]
59. Cloruro De Mercurio
60. Mercury (ii)chloride
61. Mercury(ii)-chloride
62. Mercuric Chloride, Solid
63. Epitope Id:158532
64. Wln: Hg G2
65. Mercuric Chloride [mercury And Mercury Compounds]
66. Mercury(ii) Chloride, >=98%
67. Mercury(ii) Chloride, Puratronic?
68. Nsc353255
69. Mercury(ii) Chloride, Ar, >=99%
70. Mercury(ii) Chloride, Lr, >=99%
71. Db13765
72. Un 1624
73. Mercuric Chloride [un1624] [poison]
74. Ncgc00249199-01
75. Nci60_003160
76. Mercury(ii) Chloride, Reagentplus(r), 99%
77. D01905
78. Mercury(ii) Chloride, Acs Reagent, >=99.5%
79. Q143200
80. Mercury(ii) Chloride, 99.999% Trace Metals Basis
81. Mercury(ii) Chloride, P.a., Acs Reagent, 99.5%
82. Mercury(ii) Chloride, Jis Special Grade, >=99.5%
83. Mercury(ii) Chloride, Puriss. P.a., Acs Reagent, >=99.5% (kt)
84. Mercury(ii) Chloride, Anhydrous, Powder, 99.998% Trace Metals Basis
85. Mercury(ii) Chloride, Anhydrous, Beads, -10 Mesh, 99.999% Trace Metals Basis
86. Mercury(ii) Chloride, Puriss. P.a., Acs Reagent, Reag. Iso, >=99.5% (calc. To The Dried Substance)
| Molecular Weight | 271.50 g/mol |
|---|---|
| Molecular Formula | Cl2Hg |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 271.908349 g/mol |
| Monoisotopic Mass | 271.908349 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 3 |
| Formal Charge | 0 |
| Complexity | 2.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Anti-Infective Agents, Local; Disinfectants
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
TOPICAL ANTISEPTIC, DISINFECTANT; MEDICATION (VET): CAUSTIC, ANTISEPTIC, DISINFECTANT
The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 839
Disinfectants
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) (See all compounds classified as Disinfectants.)
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)
D - Dermatologicals
D08 - Antiseptics and disinfectants
D08A - Antiseptics and disinfectants
D08AK - Mercurial products
D08AK03 - Mercuric chloride
A COMPARATIVE STUDY OF THE LOCALIZATION OF HG FROM HGCL2 ... FOLLOWING SC ADMIN IN RABBIT SHOWED HG TO ACCUMULATE IN ... COLLECTING TUBULES, THE DISTAL PORTIONS OF PROXIMAL CONVOLUTED TUBULES & THE WIDE PARTS OF HENLE'S LOOP. NO HG ... IN GLOMERULI ...
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 1783
KINETIC STUDIES OF MERCURIC CHLORIDE INDICATED THAT MERCURY WAS CONTAINED IN 3 COMPARTMENTS OF SHORT, MEDIUM & LONG RETENTION TIME WITHIN RAT. KIDNEYS WERE LARGEST COMPARTMENT FOR MERCURY & KIDNEY RETENTION PROBABLY ACCOUNTED FOR LONG-TERM COMPARTMENT.
Menzie, C.M. Metabolism of Pesticides, Update II. U.S. Department of the Interior, Fish Wildlife Service, Special Scientific Report - Wildlife No. 2l2. Washington, DC: U.S. Government Printing Office, 1978., p. 175
WHEN GOAT WAS GIVEN (203)HGCL2, LESS THAN 30% OF DOSE WAS ABSORBED. EXCRETION OF (203)HG IN MILK ACCOUNTED FOR 0.22% OF DOSE.
Menzie, C.M. Metabolism of Pesticides, Update II. U.S. Department of the Interior, Fish Wildlife Service, Special Scientific Report - Wildlife No. 2l2. Washington, DC: U.S. Government Printing Office, 1978., p. 175
DATA ... INDICATE THAT LESS THAN 10% OF INGESTED MERCURIC CHLORIDE IS ABSORBED. UPON HIGH INTAKE CORROSIVE ACTION ... MAY ALTER PERMEABILITY OF GASTROINTESTINAL TRACT ENHANCING ABSORPTION.
Friberg, L., Nordberg, G.F., Kessler, E. and Vouk, V.B. (eds). Handbook of the Toxicology of Metals. 2nd ed. Vols I, II.: Amsterdam: Elsevier Science Publishers B.V., 1986., p. 409
For more Absorption, Distribution and Excretion (Complete) data for MERCURIC CHLORIDE (9 total), please visit the HSDB record page.
STUDIES INDICATED THAT LIVERS OF YELLOWFIN TUNA AND ALBACORE HAVE HIGH ACTIVITY IN FORMATION OF METHYLMERCURY FROM HGCL2. THIS ACTIVITY ... NOT FOUND IN THE MEAT. WHEN LIVER-HGCL2 MIXTURES WERE EXPOSED TO VISIBLE LIGHT DURING INCUBATION, FORMATION OF METHYL MERCURY WAS REDUCED BY ABOUT 75%.
Menzie, C. M. Metabolism of Pesticides, An Update. U.S. Department of the Interior, Fish, Wild-life Service, Special Scientific Report - Wildlife No. 184, Washington, DC: U.S. Government Printing Office, l974., p. 241
Unilateral nephrectomy induces a dramatic change in single-kidney structure and function. Therefore, the effects of nephrotoxins may be altered. To evaluate this possibility, mercuric chloride (2 mg/kg, subcutaneous was given to male, Sprague-Dawley rats 2 days following either unilateral nephrectomy or sham surgery. Nonoliguric acute renal failure developed and was qualitatively similar in both groups. Glomerular filtration rate reached a nadir on day 2 and was reduced to a greater extent in the unilateral nephrectomy group. Furthermore, recovery of glomerular filtration was slower and occurred to lesser extent by day 10 in the animals subjected to unilateral nephrectomy. Evidence of significant tubular dysfunction was present during the acute phase in both groups, as reflected by changes in the fractional excretion of sodium or lysozyme. Persistent tubular dysfunction was noted on day 10 in both the sham and unilateral nephrectomy groups, but the degree of dysfunction was greater in the unilateral nephrectomy animals. The in vitro uptake of organic ions by renal cortical slices was reduced 24 hr following the injection of mercuric chloride although no difference was seen between the experimental groups. Merury content within renal cortex was not increased in the unilateral nephrectomy group at 1 or 3 hr but was higher 24 hr postinjection. Total urinary mercury excretion during the first day was not altered by unilateral nephrectomy although single-kidney excretion was increased dramatically.
PMID:3705072 Houser MT, Berndt WO; Toxicol Appl Pharmacol 83 (3): 506-15 (1986)
Six day old rats were treated subcutaneously with the proximal tubule toxicant mercuric chloride (1 or 3.2 mg/kg) or saline. Twenty four hours later, when evidence of mercury nephrotoxicity is detectable, creatinine clearance, and the fractonal excretion of water and various components of the filtrate were determined using a 2 hr clearance priod immediately after injection of a diuretic. The effects of mercury (3.2 mg/kg) were consistent with its ability to cause acute renal failure and proximal tubular necrosis and also indicated an apparent disruption of the cycling of urea in the nephron. A decrease in the fractional excretion of water, combined sodium and potassium and total osmotic solutes indicated that the diuretic response tho acetazolamide was markedly attenuated in the mercuric chloride-treated pups whereas the responses to furosemide, chlorothiazide and amiloride were not altered by mercury treatment.
PMID:3612527 Gray JA, Kavlock RJ; J Pharmacol Exp Ther 242 (1): 212-16 (1987)
Cultures of some aerobically grown strains of Salmonella typhimurium and Escherichia coli contain up to 24 uM extracellular glutathione ... in addition to having intracellular glutathione concentrations in the millimolar range. The addition of 26 uM glutathione to cultures of S typhimurium strain TA1534 partially protected the bacteria from the toxic effects causing growth delay by 54 uM N-methyl-N'-nitro-N-nitrosoguanidine. ... The addition of micromolar glutathione to cultures of an Escherichia coli glutathione strain protected the cells from growth inhibition by micromolar concentrations of mercuric chloride, methyl mercuric chloride, silver nitrate, cisplatin, cadmium chloride, cadmium sulfate, and iodoacetamide. In the cases of mercuric chloride, cisplatin, N-methyl-N'nitro-nitorsoguanidine, silver nitrate, and iodoacetamide, reaction products with glutathione were detected by paper chromatography.
PMID:3533525 Owens RA, Hartman PE; Environ Mutagen 8 (5): 659-74 (1986)
As manifest by tubular collapse and the virtual absence of flow into the glomerulotubular junction, filtration in most nephrons (SNGFR) of rats poisoned with 9 mg/kg body wt mercuric chloride 16 to 28 hours earlier was virtually absent. Arterial colloid osmotic pressure and Bowman's space pressure were modestly depressed (p < 0.05) and mean blood pressure was reduced from 115 +/- mm mercury (SEM) to 97 +/- 1 mm mercury (p < 0.001). Glomerular capillary hydraulic pressure (Pg), 25.6 +/- 1.3 mm mercury was some 24 mm mercury lower than control (p < 0.001) and yielded a net afferent effective filtration pressure (Pnet) of 4.1 +/- 1.2 mm mercury. Excluding three rats with values greater than 10 mm mercury net afferent effective filtration pressure averaged 2.0 +/- 0.9 mm mercury (n= 7 rats) versus 20.0 +/- 1.8 mm mercury in controls (n= 10, p < 0.001), the former being statistically almost indistinguishable from 0 mm mercury and barely able to support any filtration. This decrease in Hg was caused by a major increase in preglomerular resistance and a reciprocal fall in efferent arteriolar resistance, the preglomerular resistance/efferent arteriolar resistance ratio of 7.2 +/- 0.8 being four fold higher than control (p < 0.001). Renocortical blood flow was not different from control (p > 0.2).
PMID:3656937 Wolfert AI et al; Kidney Int 32 (2): 246-55 (1987)
For more Mechanism of Action (Complete) data for MERCURIC CHLORIDE (11 total), please visit the HSDB record page.
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