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Symbiotec Dexamethasone Acetate Symbiotec Dexamethasone Acetate

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    Technical details about Dexamethasone Acetate, learn more about the structure, uses, toxicity, action, side effects and more

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    Dexamethasone Acetate

    APIs // Active Pharmaceutical Ingredients

    DOSSIERs // Finished Dosage Forms

    MARKET PLACE

    ANALYTICAL SOLUTION(s)

    DIGITAL CONTENT

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    2D Structure
    Also known as: 1177-87-3, Dexamethasone 21-acetate, Decadronal, Decadron-la, Panasone, Dexamethasone acetate anhydrous
    Molecular Formula
    C24H31FO6
    Molecular Weight
    434.5  g/mol
    InChI Key
    AKUJBENLRBOFTD-RPRRAYFGSA-N
    FDA UNII
    K7V8P532WP
    Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
    2.1.2 InChI
    InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1
    2.1.3 InChI Key
    AKUJBENLRBOFTD-RPRRAYFGSA-N
    2.1.4 Canonical SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C
    2.1.5 Isomeric SMILES
    C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)F)C
    2.2 Other Identifiers
    2.2.1 UNII
    K7V8P532WP
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dexamethasone Acetate, (6alpha,11beta)-isomer

    2. Fortecortin

    2.3.2 Depositor-Supplied Synonyms

    1. 1177-87-3

    2. Dexamethasone 21-acetate

    3. Decadronal

    4. Decadron-la

    5. Panasone

    6. Dexamethasone Acetate Anhydrous

    7. Fortecortin (crystal Suspension)

    8. Dectan

    9. Dex-cortidelt Acetate

    10. Dexamethasone-21-acetate

    11. 21-o-acetyl Dexamethasone

    12. Nsc 39471

    13. Chebi:4463

    14. Nsc-39471

    15. Mls000028544

    16. Mls001148106

    17. K7v8p532wp

    18. Dexamethasone Acetate, Anhydrous

    19. Chembl1530428

    20. 9alpha-fluoro-16alpha-methylprednisolone Acetate

    21. 16alpha-methyl-9alpha-fluoroprednisolone 21-acetate

    22. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16alpha)-

    23. Smr000058327

    24. Dexamethason Acetate

    25. Dsstox_cid_2901

    26. Dsstox_rid_76780

    27. Dsstox_gsid_22901

    28. [2-[(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

    29. 2-((8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate

    30. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11.beta.,16.alpha.)-

    31. 9.alpha.-fluoro-16.alpha.-methylprednisolone Acetate

    32. 16.alpha.-methyl-9.alpha.-fluoroprednisolone 21-acetate

    33. 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione 21-acetate

    34. Fortecortin (van)

    35. Mfcd00027407

    36. Unii-k7v8p532wp

    37. Dalalone Dp

    38. Dalalone La

    39. Dexamethasone Acetate, (6alpha,11beta)-isomer

    40. Ncgc00016566-01

    41. Decadron-l.a.

    42. Dexamethasoni Acetas

    43. Prestwick_157

    44. Cas-1177-87-3

    45. Einecs 214-646-8

    46. Dexamethasone-acetate

    47. Dexamethasone (acetate)

    48. Acetic Acid Dexamethasone

    49. Decaject-l.a. (tn)

    50. Opera_id_1620

    51. Prestwick0_000130

    52. Prestwick1_000130

    53. Prestwick2_000130

    54. Prestwick3_000130

    55. Bspbio_000180

    56. Schembl136861

    57. 9alpha-fluoro-16alpha-methylprednisolone-21-acetate

    58. Spbio_002119

    59. Bpbio1_000198

    60. Dexamethasoni Acetas Monohydrate

    61. Dtxsid8022901

    62. Brd5719

    63. Hms1568i22

    64. Hms2095i22

    65. Hms2233a20

    66. Hms3712i22

    67. Bcp28591

    68. Brd-5719

    69. Dexamethasone 21-acetate, >=99%

    70. Nsc39471

    71. Zinc3882068

    72. Tox21_110499

    73. Tox21_112928

    74. Bdbm50103620

    75. Hy-14648a

    76. S3124

    77. Akos015951406

    78. Dexamethasone Acetate [usp-rs]

    79. Dexamethasone Acetate [who-dd]

    80. Dexamethasone Acetate [who-ip]

    81. Tox21_112928_1

    82. Ccg-220130

    83. Cs-1941

    84. Db14649

    85. Dexamethasone 21-acetate [mi]

    86. 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione Acetate

    87. Ncgc00022662-03

    88. Ncgc00022662-05

    89. Ncgc00022662-06

    90. 2-((2s,10s,11s,15s,17s,1r,13r,14r)-1-fluoro-14,17-dihydroxy-2,13,15-trimethyl- 5-oxotetracyclo[8.7.0.0<2,7>.0<11,15>]heptadeca-3,6-dien-14-yl)-2-oxoethyl Ace Tate

    91. As-13327

    92. Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-, 21-acetate

    93. Dexamethasone Acetate [ep Monograph]

    94. Dexamethasoni Acetas [who-ip Latin]

    95. Dexamethasone Acetate [usp Monograph]

    96. Dexamethasone Impurity G [ep Impurity]

    97. C08174

    98. D07796

    99. 177d873

    100. Sr-01000000099

    101. Sr-01000000099-2

    102. W-108559

    103. Betamethasone Acetate Impurity B [ep Impurity]

    104. Brd-k47635719-001-03-9

    105. Brd-k47635719-001-21-1

    106. Q27106392

    107. Dexamethasone 21-acetate 100 Microg/ml In Acetonitrile

    108. Dexamethasone 21-acetate 1000 Microg/ml In Acetonitrile

    109. Prednisolone, 9.alpha.-fluoro-16.alpha.-methyl-, Acetate

    110. Dexamethasone 21-acetate, Vetranal(tm), Analytical Standard

    111. Dexamethasone Acetate, European Pharmacopoeia (ep) Reference Standard

    112. Dexamethasone Acetate, United States Pharmacopeia (usp) Reference Standard

    113. Dexamethasone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

    114. Pregna-1,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-, 21-acetate

    115. Pregna-1,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-, Acetate

    116. Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, Acetate

    117. [2-[(8r,9s,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

    118. 9-fluoro-11.beta.,17-dihydroxy-16.alpha.-methyl-3,20-dioxopregna-1,4-dien-21-yl Acetate #

    119. Pregna-1,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11.beta.,16.alpha.)-

    120. Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-, Acetate

    121. Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 21-acetate

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 434.5 g/mol
    Molecular Formula C24H31FO6
    XLogP32.8
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count4
    Exact Mass434.21046687 g/mol
    Monoisotopic Mass434.21046687 g/mol
    Topological Polar Surface Area101 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity910
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

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