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    Technical details about Ceftolozane Sulfate, learn more about the structure, uses, toxicity, action, side effects and more

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    Ceftolozane Sulfate

    APIs // Active Pharmaceutical Ingredients

    INTERMEDIATES

    DOSSIERs // Finished Dosage Forms

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    2D Structure
    1. Also known as: 936111-69-2, Cxa-101, Ceftolozane sulfate [usan], 7r247u84hy, Fr264205, Fr-264205
    Molecular Formula
    C23H32N12O12S3
    Molecular Weight
    764.8  g/mol
    InChI Key
    UJDQGRLTPBVSFN-TVNHLQOTSA-N
    FDA UNII
    7R247U84HY
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (6R,7R)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrogen sulfate
    2.1.2 InChI
    InChI=1S/C23H30N12O8S2.H2O4S/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24;1-5(2,3)4/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42);(H2,1,2,3,4)/b31-11-;/t12-,18-;/m1./s1
    2.1.3 InChI Key
    UJDQGRLTPBVSFN-TVNHLQOTSA-N
    2.1.4 Canonical SMILES
    CC(C)(C(=O)O)ON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)O.OS(=O)(=O)[O-]
    2.1.5 Isomeric SMILES
    CC(C)(C(=O)O)O/N=C(/C1=NSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)O.OS(=O)(=O)[O-]
    2.2 Other Identifiers
    2.2.1 UNII
    7R247U84HY
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ceftolozane

    2. Cxa-101

    3. Fr 264205

    4. Fr-264205

    5. Fr26 4205

    6. Fr264205

    2.3.2 Depositor-Supplied Synonyms

    1. 936111-69-2

    2. Cxa-101

    3. Ceftolozane Sulfate [usan]

    4. 7r247u84hy

    5. Fr264205

    6. Fr-264205

    7. Ceftolozane

    8. (6r,7r)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-7-[[(2z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;hydrogen Sulfate

    9. Cxa-101 (for Sulfate)

    10. Unii-7r247u84hy

    11. Cxa 101

    12. Fr 264205

    13. Ceftolozane Sulfate [mi]

    14. Ceftolozane Sulfate (jan/usan)

    15. Ceftolozane Sulfate [jan]

    16. Cxa-301

    17. Dtxsid001027693

    18. Ceftolozane Sulfate [vandf]

    19. Ex-a4483

    20. Ceftolozane Sulfate [who-dd]

    21. Ceftolozane Sulfate [orange Book]

    22. Ac-36560

    23. Zerbaxa Component Ceftolozane Sulfate

    24. Ceftolozane Sulfate Component Of Zerbaxa

    25. D10098

    26. 1h-pyrazolium, 5-amino-4-((((2-aminoethyl)amino)carbonyl)amino)-2-(((6r,7r)-7-(((2z)- 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2- Carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, Sulfate (1:1)

    27. 5-amino-4-(((2-aminoethyl)carbamoyl)amino)-2-(((6r,7r)-7-(((2z)-2-(5-amino-1,2,4- Thiadiazol-3-yl)-2-((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5- Thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-1h-pyrazolium Monosulfate

    28. 5-amino-4-(((2-aminoethyl)carbamoyl)amino)-2-(((6r,7r)-7-(((2z)-2-(5-amino-1,2,4- Thiadiazol-3-yl)-2-((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-1h-pyrazolium Monosulfate

    2.4 Create Date
    2011-06-02
    3 Chemical and Physical Properties
    Molecular Weight 764.8 g/mol
    Molecular Formula C23H32N12O12S3
    Hydrogen Bond Donor Count9
    Hydrogen Bond Acceptor Count20
    Rotatable Bond Count12
    Exact Mass764.14247802 g/mol
    Monoisotopic Mass764.14247802 g/mol
    Topological Polar Surface Area439 Ų
    Heavy Atom Count50
    Formal Charge0
    Complexity1360
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

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