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1. 7758-87-4
2. Tricalcium Phosphate
3. Synthos
4. Calcium Phosphate Tribasic
5. Calcium Orthophosphate
6. Tricalcium Diphosphate
7. Calcigenol Simple
8. Beta-tcp
9. Tricalcium Orthophosphate
10. Beta-tricalcium Phosphate
11. Calcium Tertiary Phosphate
12. Tertiary Calcium Phosphate
13. Phosphoric Acid, Calcium Salt (2:3)
14. Fema No. 3081
15. Calcium Phosphate (3:2)
16. Tri-calcium Phosphate
17. Tricalcium;diphosphate
18. 10103-46-5
19. Calciresorb;tcp
20. Phosphoric Acid, Calcium Salt
21. Tricalcium Bis(phosphate)
22. Alpha-tricalcium Phosphate
23. Ins No.341(iii)
24. Chebi:9679
25. Ins-341(iii)
26. E-341(iii)
27. K4c08xp666
28. Synthograft
29. Bonarka
30. Cerasorb
31. Osferion
32. Natural Whitlockite
33. Caswell No. 148
34. Ceredex
35. Multifos
36. Ostram
37. Vitoss
38. Calciumphosphate
39. Tricos
40. Calipharm T
41. Tricafos P
42. 21063-37-6
43. Tricalcium Bis(orthophosphate)
44. Ccris 3668
45. Hsdb 879
46. Jax Tcp
47. Calcium Phosphate (ca3(po4)2)
48. Calcium Orthophosphate, Tri-(tert)
49. Tricalcium Phosphate (ca3(po4)2)
50. Einecs 231-840-8
51. Einecs 233-283-6
52. Unii-97z1wi3ndx
53. Epa Pesticide Chemical Code 076401
54. Posture (calcium Supplement)
55. Bone Phosphate
56. Phosphoric Acid Calcium(2+) Salt (2:3)
57. Unii-k4c08xp666
58. Ca3(po4)2
59. Calcium-phosphate
60. Alpha-tcp
61. Calcium Phosphates
62. Tricalciumphosphate
63. Posture (tn)
64. Hydroxyapatite Powder
65. Mfcd00015984
66. Calcigenol
67. Calcium Phosphate Basic
68. Beta Tricalcium Phosphate
69. Ai3-25607
70. Ec 231-840-8
71. 97z1wi3ndx
72. Chembl2106566
73. Dtxsid1049803
74. Calcium Phosphate [who-dd]
75. Tricalcium Phosphate [fhfi]
76. Tricalcium Phosphate [inci]
77. Precipitated Calcium Phosphate
78. Akos015833108
79. Phosphoric Acid, Calcium Salt (1:?)
80. Cx-0072
81. Db11348
82. Calcium Phosphate, Tribasic [mi]
83. Tricalcium Bis(orthophosphate), With A Fluorine Content Of Less Than 0,005 % By Weight On The Dry Anhydrous Product
84. Calcium Phosphate, Tribasic (ca.37% Ca)
85. Calcium Phosphate, Tribasic [hsdb]
86. Calcium Phosphate,anhydrous [vandf]
87. C3736
88. Cs-0013475
89. Ft-0645103
90. C08136
91. D00938
92. Q278387
93. Calcium Phosphate, Reagent For Transient & Stable Dna Transfections
94. Beta-tri-calcium Phosphate, >=95% Beta-phase Basis (unsintered Powder)
95. Calcium Phosphate, Purum P.a., >=96.0% (calc. As Ca3(po4)2, Kt)
96. Tricalcium Phosphate Hydrate, Nanopowder, <200 Nm Particle Size (bet)
97. Alpha-tri-calcium Phosphate, Puriss. P.a., >=75% Alpha-phase Basis (sinterted Powder)
98. Alpha-tri-calcium Phosphate, Reagent For Transient & Stable Dna Transfections
99. Beta-tri-calcium Phosphate, Puriss. P.a., >=95% Beta-phase Basis (sintered Powder)
100. Beta-tri-calcium Phosphate, Puriss. P.a., >=98% Beta-phase Basis (sintered Powder)
101. Beta-tri-calcium Phosphate, Puriss. P.a., >=98% Beta-phase Basis (unsintered Powder)
102. Calcium Phosphate (3:2) Mixture With Calcium Phosphate (1:1) [who-ip]
| Molecular Weight | 310.18 g/mol |
|---|---|
| Molecular Formula | Ca3O8P2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 0 |
| Exact Mass | 309.7946135 g/mol |
| Monoisotopic Mass | 309.7946135 g/mol |
| Topological Polar Surface Area | 173 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 36.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 5 |
... CHIEFLY USED AS GASTRIC ANTACID ... VALUABLE SOURCE OF CALCIUM ION, ESPECIALLY WHEN IT IS DESIRED TO SUPPLY BOTH CALCIUM & PHOSPHORUS. /FORMER USE/
Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1528
... /THIS/ ORALLY ADMIN CALCIUM ... /SALT/ CAN BE USED IN TREATMENT OF MILD & LATENT HYPOCALCEMIC TETANY & FOR MAINTENANCE THERAPY ... .
American Medical Association, Council on Drugs. AMA Drug Evaluations. 2nd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1973., p. 202
AN EXCELLENT SOURCE OF BOTH CALCIUM AND PHOSPHORUS USEFUL IN SUPPLEMENTING CALCIUM INTAKE, AS, FOR EXAMPLE, DURING PREGNANCY & LACTATION, OR AS SOURCE OF CALCIUM IN DISEASES OF CALCIUM DEFICIENCY.
Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 770
Calcium replenisher
Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 256
For more Therapeutic Uses (Complete) data for TRICALCIUM PHOSPHATE (6 total), please visit the HSDB record page.
... CONTRAINDICATED IN TREATMENT OF HYPOCALCEMIA WITH HYPERPHOSPHATEMIA, WHICH MAY OCCUR IN HYPOPARATHYROIDISM AND RENAL FAILURE.
American Medical Association, Council on Drugs. AMA Drug Evaluations. 2nd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1973., p. 201
Ceramic implant materials, including tricalcium phosphate, are biocompatible and are currently being used to restore alveolar bone loss resulting from periodontal disease, endodontic infections, and residual alveolar ridge resorption. However, use of such a material in this case led to persistent infection and additional bone destruction. Thus, the use of a ceramic implant material to accelerate periapical bone repair is not recommended in areas where a chronic bacterial infection is present.
PMID:3457349 Barkhordar RA, Meyer JR; Oral Surg Oral Med Oral Pathol 61 (2): 201-6 (1986)
For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste.
FDA Label
Calcium phosphate reacts with acid in the stomach to raise the pH. In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth. As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.
A - Alimentary tract and metabolism
A12 - Mineral supplements
A12A - Calcium
A12AA - Calcium
A12AA01 - Calcium phosphate
/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/
Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1524
A defect in phosphate metabolism occurs in a variety of diseases. ... Rickets ... Osteomalacia ... Primary or Secondary Hyperparathyroidism ... Chronic Renal Failure. /Phosphates/
Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1525
The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.
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