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    Technical details about Bretylium Tosylate, learn more about the structure, uses, toxicity, action, side effects and more

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    Bretylium Tosylate

    APIs // Active Pharmaceutical Ingredients

    DOSSIERs // Finished Dosage Forms

    MARKET PLACE

    ANALYTICAL SOLUTION(s)

    DIGITAL CONTENT

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    2D Structure
    1. Also known as: 61-75-6, Bretylol, Bretylium tosilate, Bretylate, Ornid, Darenthin
    Molecular Formula
    C18H24BrNO3S
    Molecular Weight
    414.4  g/mol
    InChI Key
    KVWNWTZZBKCOPM-UHFFFAOYSA-M
    FDA UNII
    78ZP3YR353
    An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2-bromophenyl)methyl-ethyl-dimethylazanium;4-methylbenzenesulfonate
    2.1.2 InChI
    InChI=1S/C11H17BrN.C7H8O3S/c1-4-13(2,3)9-10-7-5-6-8-11(10)12;1-6-2-4-7(5-3-6)11(8,9)10/h5-8H,4,9H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
    2.1.3 InChI Key
    KVWNWTZZBKCOPM-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CC[N+](C)(C)CC1=CC=CC=C1Br.CC1=CC=C(C=C1)S(=O)(=O)[O-]
    2.2 Other Identifiers
    2.2.1 UNII
    78ZP3YR353
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bretylate

    2. Bretylium Tosilate

    3. Bretylol

    4. Ornid

    2.3.2 Depositor-Supplied Synonyms

    1. 61-75-6

    2. Bretylol

    3. Bretylium Tosilate

    4. Bretylate

    5. Ornid

    6. Darenthin

    7. N-(2-bromobenzyl)-n,n-dimethylethanaminium 4-methylbenzenesulfonate

    8. Darentin

    9. Bretylan

    10. Bretylium (tosylate)

    11. Bretylium P-toluenesulfonate

    12. Asl-603

    13. Bretylii Tosilas

    14. Tosilato De Bretilio

    15. Tosilate De Bretylium

    16. (o-bromobenzyl)ethyldimethylammonium P-toluenesulfonate

    17. Nsc-62164

    18. Bretylium Tosilate [inn]

    19. 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium 4-methylbenzenesulfonate

    20. Dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate

    21. N-ethyl-n-o-bromobenzyl-n,n-dimethylammonium Tosylate

    22. Benzenemethanaminium, 2-bromo-n-ethyl-n,n-dimethyl-, Salt With 4-methylbenzenesulfonic Acid (1:1)

    23. Mls000028635

    24. Chebi:3173

    25. 78zp3yr353

    26. Cas-61-75-6

    27. Ncgc00016119-02

    28. Asl 603

    29. Smr000058647

    30. Bretylium Tosilate (inn)

    31. Bretilio Tosilato

    32. Bretilio Tosilato [dcit]

    33. Nsc 62164

    34. Bretylii Tosilas [inn-latin]

    35. Nsc62164

    36. Bretylium Tosylate In Dextrose 5%

    37. Sr-01000000254

    38. Tosilate De Bretylium [inn-french]

    39. Tosilato De Bretilio [inn-spanish]

    40. Einecs 200-516-8

    41. Bretylium Tosylate (usp)

    42. Bretylium Tosylate In Plastic Container

    43. Unii-78zp3yr353

    44. Bretylium Tosylate [usan:usp]

    45. Bretyliume Tosylate

    46. Bretylol (tn)

    47. Bretylium Tosylate In Dextrose 5% In Plastic Container

    48. Opera_id_1513

    49. Lopac-b-8406

    50. Dsstox_cid_2685

    51. Benzenemethanaminium, 2-bromo-n-ethyl-n,n-dimethyl-, Salt With 4-methylbenzenesulfonic Acid

    52. Dsstox_rid_76691

    53. Dsstox_gsid_22685

    54. Schembl40898

    55. Bretylium Tosylate [mi]

    56. Chembl1095292

    57. Dtxsid1022685

    58. Bretylium Tosylate [usan]

    59. Bretylium Tosylate [vandf]

    60. Hms1570n06

    61. Hms2097n06

    62. Hms2235i21

    63. Hms3714n06

    64. Bretylium Tosilate [mart.]

    65. Ammonium, (o-bromobenzyl)ethyldimethyl-, P-toluenesulfonate

    66. Bretylium Tosilate [who-dd]

    67. Bretylium Tosylate [usp-rs]

    68. Tox21_110308

    69. (2-bromophenyl)methyl-ethyl-dimethylazanium;4-methylbenzenesulfonate

    70. Hy-12961a

    71. Mfcd00038731

    72. Akos015842525

    73. Ccg-204319

    74. Cs-5728

    75. Bretylium Tosylate [orange Book]

    76. Ncgc00016119-01

    77. Ncgc00016119-03

    78. Ncgc00016119-04

    79. Ncgc00024457-02

    80. As-56957

    81. Bretylium Tosylate [usp Monograph]

    82. Wln: Er B1k2&1&1 &oswr D1

    83. Bretylium Tosylate, >99% (tlc), Powder

    84. (2-bromobenzyl)ethyldimethylammonium Tosylate

    85. Eu-0100224

    86. Ft-0603258

    87. B 8406

    88. D00645

    89. Sr-01000000254-2

    90. Sr-01000000254-5

    91. Q27105972

    92. (2-bromobenzyl)ethyldimethylammonium Toluene-4-sulfonate

    93. (o-bromobenzyl)ethyldimethylammonium P-toluenesulphonate

    94. N-(2-bromobenzyl)-n,n-dimethylethanaminium4-methylbenzenesulfonate

    95. [(2-bromophenyl)methyl](ethyl)dimethylazanium 4-methylbenzene-1-sulfonate

    96. 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium 4-methyl-benzenesulfontate

    97. Bretylium Tosylate, United States Pharmacopeia (usp) Reference Standard

    98. N-[(2-bromophenyl)methyl]-n,n-dimethylethanaminium 4-methylbenzenesulfonate

    99. Benzenemethanaminium,n-dimethyl-, Salt With 4-methylbenzenesulfonic Acid (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 414.4 g/mol
    Molecular Formula C18H24BrNO3S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass413.06603 g/mol
    Monoisotopic Mass413.06603 g/mol
    Topological Polar Surface Area65.6 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity349
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Adrenergic Antagonists

    Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE. (See all compounds classified as Adrenergic Antagonists.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    4.2 ATC Code

    C - Cardiovascular system

    C01 - Cardiac therapy

    C01B - Antiarrhythmics, class i and iii

    C01BD - Antiarrhythmics, class iii

    C01BD02 - Bretylium tosilate

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