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Technical details about Betamethasone Valerate, learn more about the structure, uses, toxicity, action, side effects and more

Betamethasone Valerate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

44 Suppliers, 18 USDMF, 11 CEP/COS, 4 JDMF, 7 EU WC, 1 KDMF, 9 NDC API, 26 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

DOSSIERs // Finished Dosage Forms

95 Dossiers, 33 FDA Orange Book, 18 Europe, 14 Canada, 18 Australia, 3 South Africa, 9 Listed Dossiers

DRUG PRODUCT COMPOSITION

CREAM;TOPICAL - EQ 0.1% BASE, OINTMENT;TOPICAL - EQ 0.1% BASE, LOTION;TOPICAL - EQ 0.1% BASE, AEROSOL, FOAM;TOPICAL - 0.12%

RELATED EXCIPIENT COMPANIES

Suppliers, 16 BASF, 3 Actylis, 3 Nanjing Well Pharmaceutical, 2 Lubrizol Life Science Health, 2 Seqens, 2 Gangwal Chemicals, 2 Nomisma Healthcare, 2 Finar, 2 Seppic, 1 Corel Pharma Chem, 1 Clariant

EXCIPIENTS BY APPLICATIONS

22 Topical, 8 Solubilizers, 8 Thickeners and Stabilizers, 5 Controlled & Modified Release, 4 Film Formers & Plasticizers, 3 Parenteral, 2 Granulation, 2 Lubricants & Glidants, 2 Emulsifying Agents, 1 Direct Compression, 1 Surfactant & Foaming Agents, 1 Fillers, Diluents & Binders, 1 Rheology Modifiers, 1 Coating Systems & Additives

GLOBAL SALES INFORMATION

14 US Medicaid Prescriptions, 11 Finished Drug Prices

MARKET PLACE

8 APIs

8 APIs

PATENTS

2 Health Canada Patents

2 Health Canada Patents

ANALYTICAL SOLUTION(s)

5 EDQM Standards, 2 USP Standards, 5 JP Standards, 2 Other Ref. Standards

DIGITAL CONTENT

5 News

5 News

Also known as: Betamethasone 17-valerate, 2152-44-5, Betnovate, Betaderm, Luxiq, Beta-val

Molecular Formula

C₂₇H₃₇FO₆

Molecular Weight

476.6 g/mol

InChI Key

SNHRLVCMMWUAJD-SUYDQAKGSA-N

FDA UNII

9IFA5XM7R2

The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate

2.1.2 InChI

InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

2.1.3 InChI Key

SNHRLVCMMWUAJD-SUYDQAKGSA-N

2.1.4 Canonical SMILES

CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO

2.1.5 Isomeric SMILES

CCCCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CO

2.2 Other Identifiers

2.2.1 UNII

9IFA5XM7R2

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 17-valerate, Betamethasone

2. Betamethasone 17 Valerate

3. Betamethasone 17-valerate

4. Betnovate

5. Flubenisolonvalerate

6. Valerate, Betamethasone

2.3.2 Depositor-Supplied Synonyms

1. Betamethasone 17-valerate

2. 2152-44-5

3. Betnovate

4. Betaderm

5. Luxiq

6. Beta-val

7. Betatrex

8. Tokuderm

9. Valnac

10. Betamethasone-17-valerate

11. Celestoderm

12. Bedermin

13. Bextasol

14. Stanoval

15. Rinderon V

16. Dermovaleas

17. Betneval

18. Dermosol

19. Beta-methasone 17-valerate

20. Ecoval 70

21. Betamethasone 17a-valerate

22. Betamethasone (as Valerate)

23. 9ifa5xm7r2

24. Chebi:31277

25. Betamethasone Valerate (betnovate)

26. Nsc-755912

27. [(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Pentanoate

28. Betnovateat

29. Celeston Valerate

30. 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17-valerate

31. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-17-valerate

32. 9-fluoro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Pentanoate

33. 9-fluoro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Valerate

34. Topagen (veterinary)

35. Gentocin (veterinary)

36. Betamethasone Valerate (betamethasone 17-valerate)

37. Bettamousse

38. Betaval

39. Fuciderm

40. Betoid

41. Celestoderm V

42. Celestoderm-v

43. Betnesol V

44. Betnesol-v

45. Celestan V

46. Celestan-v

47. Celestane V

48. Ncgc00274064-01

49. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopentyl)oxy)-, (11.beta.,16.beta.)-

50. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (11.beta.,16.beta.)-

51. Einecs 218-439-3

52. Betamethasoni Valeras

53. Rinderon-v (tn)

54. Betamethasone-valerate

55. Luxiq (tn)

56. Topagen (salt/mix)

57. Beta-val (tn)

58. Betatrex (salt/mix)

59. Gentocin (salt/mix)

60. Chlorophytum Borivilanum

61. Betamethason-17-valerate

62. Dsstox_cid_2673

63. Unii-9ifa5xm7r2

64. Schembl7270

65. Chembl1497

66. Dsstox_rid_76684

67. Dsstox_gsid_22673

68. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopentyl)oxy)-, (11beta,16beta)-

69. Betamethasone 17alpha-valerate

70. Dtxsid7022673

71. Hy-b0727

72. Zinc3882052

73. Betamethasone Valerate (jp17/usp)

74. Betamethasone Valerate [jan]

75. Tox21_302288

76. Betamethasone Valerate [usan]

77. S1690

78. Betamethasone Valerate [vandf]

79. Akos015994704

80. Betamethasone Valerate [mart.]

81. Betamethasone Valerate [usp-rs]

82. Betamethasone Valerate [who-dd]

83. Betamethasone Valerate [who-ip]

84. Ccg-269509

85. Ks-1198

86. Nsc 755912

87. 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione-17-valerate

88. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate

89. Betamethasone 17-valerate [mi]

90. Betamethasone Valerate [usan:usp:jan]

91. Ncgc00255185-01

92. (11beta,16beta)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl Pentanoate

93. (2s,10s,11s,13s,15s,17s,1r,14r)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13, 15-trimethyl-5-oxotetracyclo[8.7.0.0<2,7>.0<11,15>]heptadeca-3,6-dien-14-yl Pe Ntanoate

94. Betamethasone Valerate [green Book]

95. Cas-2152-44-5

96. Betamethasone Valerate [orange Book]

97. Betamethasone Valerate [ep Monograph]

98. Betamethasone Valerate For System Suitability

99. Betamethasoni Valeras [who-ip Latin]

100. Cs-0009628

101. Betamethasone Valerate [usp Monograph]

102. D01357

103. Ab01274710-01

104. Ab01274710_02

105. 152m445

106. A815447

107. Q6445931

108. Betamethasone 17a-valerate 100 Microg/ml In Methanol

109. Brd-k34032314-001-04-1

110. (11.beta.,16.beta.)-9.alpha.-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17.alpha.-valerate

111. (8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl Pentanoate

112. 9-fluoro-11.beta.,21-dihydroxy-16.beta.-methyl-3,20-dioxopregna-1,4-dien-17-yl Pentanoate #

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₃₇FO₆
Molecular Weight	476.6 g/mol
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	476.25741706 g/mol
Monoisotopic Mass	476.25741706 g/mol
Topological Polar Surface Area	101 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	957
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Betamethasone valerate
PubMed Health	Betamethasone Valerate (On the skin)
Drug Classes	Corticosteroid, Intermediate
Drug Label	Luxq Foam contains betamethasone valerate, USP, a synthetic corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory agents.Betamethasone valerate is 9-...
Active Ingredient	Betamethasone valerate
Dosage Form	Lotion; Ointment; Cream; Aerosol, foam
Route	Topical
Strength	0.12%; eq 0.1% base
Market Status	Prescription
Company	Sti Pharma; Actavis Mid Atlantic; Perrigo; Fougera

2 of 2
Drug Name	Betamethasone valerate
PubMed Health	Betamethasone Valerate (On the skin)
Drug Classes	Corticosteroid, Intermediate
Drug Label	Luxq Foam contains betamethasone valerate, USP, a synthetic corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory agents.Betamethasone valerate is 9-...
Active Ingredient	Betamethasone valerate
Dosage Form	Lotion; Ointment; Cream; Aerosol, foam
Route	Topical
Strength	0.12%; eq 0.1% base
Market Status	Prescription
Company	Sti Pharma; Actavis Mid Atlantic; Perrigo; Fougera

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

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