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    Technical details about AM20070143, learn more about the structure, uses, toxicity, action, side effects and more

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    AM20070143

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

    MARKET PLACE

    ANALYTICAL SOLUTION(s)

    PharmaCompass

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    2D Structure
    Also known as: 4394-00-7, Landruma, Nifluril, Forenol, Nifluminic acid, Niflugel
    Molecular Formula
    C13H9F3N2O2
    Molecular Weight
    282.22  g/mol
    InChI Key
    JZFPYUNJRRFVQU-UHFFFAOYSA-N
    FDA UNII
    4U5MP5IUD8
    An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
    2.1.2 InChI
    InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
    2.1.3 InChI Key
    JZFPYUNJRRFVQU-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    4U5MP5IUD8
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acid, Niflumic

    2. Donalgin

    3. Flunir

    4. Niflactol

    5. Niflugel

    6. Nifluril

    2.3.2 Depositor-Supplied Synonyms

    1. 4394-00-7

    2. Landruma

    3. Nifluril

    4. Forenol

    5. Nifluminic Acid

    6. Niflugel

    7. Acido Niflumico

    8. Acide Niflumique

    9. Up 83

    10. 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic Acid

    11. Acide Niflumique [inn-french]

    12. Acido Niflumico [inn-spanish]

    13. Acidum Niflumicum [inn-latin]

    14. 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic Acid

    15. 2-(3-(trifluoromethyl)anilino)nicotinic Acid

    16. 2-(3-(trifluoromethyl)-phenyl)aminonicotinic Acid

    17. 2-(3-trifluoromethylanilino)nicotinic Acid

    18. 2-((3-(trifluoromethyl)phenyl)amino)nicotinic Acid

    19. 2-[3-(trifluoromethyl)anilino]nicotinic Acid

    20. 3-pyridinecarboxylic Acid, 2-[[3-(trifluoromethyl)phenyl]amino]-

    21. Lopac-n-0630

    22. 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic Acid

    23. 2-(3-(trifluoromethyl)phenylamino)nicotinic Acid

    24. Niflumic Acid (inn)

    25. Nsc-758196

    26. 2-[(3-trifluoromethyl)phenyl]amino-3-pyridine-carboxylic Acid

    27. 4u5mp5iud8

    28. Mls000069713

    29. Nfl

    30. Chebi:34888

    31. 3-pyridinecarboxylic Acid, 2-((3-(trifluoromethyl)phenyl)amino)-

    32. Up-83

    33. Ncgc00015724-10

    34. Niflumate

    35. Smr000058199

    36. Cas-4394-00-7

    37. Dsstox_cid_3368

    38. 2-(3-[trifluoromethyl]anilino)nicotinic Acid

    39. Acidum Niflumicum

    40. Dsstox_rid_76996

    41. Niflumic Acid [inn]

    42. Dsstox_gsid_23368

    43. Acide Niflumique [french]

    44. Acido Niflumico [italian]

    45. Niflamol

    46. Niflugel (tn)

    47. Sc 1332

    48. Ccris 5740

    49. Sr-01000000231

    50. 2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinic Acid

    51. Einecs 224-516-2

    52. 2-(3-trifluoromethyl-phenylamino)-nicotinic Acid

    53. Unii-4u5mp5iud8

    54. Brn 0489360

    55. 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic Acid

    56. Niflumic-acid

    57. Ni-flumic Acid

    58. Niflumic Acid [inn:ban:dcf]

    59. Actol, Analgesic

    60. Aza-2 Dimethyl-2',3' (tetrazolyl-5)-6 Diphenylamino [french]

    61. Prestwick_890

    62. Mfcd00010569

    63. Aza-2 Dimethyl-2',3' (tetrazolyl-5)-6 Diphenylamino

    64. Spectrum_001353

    65. 1td7

    66. Opera_id_1746

    67. Prestwick0_000255

    68. Prestwick1_000255

    69. Prestwick2_000255

    70. Prestwick3_000255

    71. Spectrum2_000794

    72. Spectrum3_001485

    73. Spectrum4_000043

    74. Spectrum5_001216

    75. Niflumic Acid (hit 16)

    76. N 0630

    77. Niflumic Acid [mi]

    78. 2-[(3-trifluoromethylphenyl)amino]nicotinic Acid

    79. Cbiol_001828

    80. Lopac0_000845

    81. Schembl24706

    82. Bspbio_000070

    83. Bspbio_001393

    84. Bspbio_003069

    85. Kbiogr_000113

    86. Kbiogr_000505

    87. Kbioss_000113

    88. Kbioss_001833

    89. 5-22-13-00598 (beilstein Handbook Reference)

    90. Mls001076327

    91. Chembl63323

    92. Divk1c_000277

    93. Spectrum1502015

    94. Spbio_000928

    95. Spbio_002289

    96. Niflumic Acid [mart.]

    97. Bpbio1_000078

    98. Gtpl2439

    99. Niflumic Acid [who-dd]

    100. Dtxsid1023368

    101. Bdbm85507

    102. Hms500n19

    103. Kbio1_000277

    104. Kbio2_000113

    105. Kbio2_001833

    106. Kbio2_002681

    107. Kbio2_004401

    108. Kbio2_005249

    109. Kbio2_006969

    110. Kbio3_000225

    111. Kbio3_000226

    112. Kbio3_002569

    113. Ninds_000277

    114. 2-[(3-trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid

    115. Bio1_000114

    116. Bio1_000603

    117. Bio1_001092

    118. Bio2_000113

    119. Bio2_000593

    120. Hms1361f15

    121. Hms1568d12

    122. Hms1791f15

    123. Hms1921d12

    124. Hms1989f15

    125. Hms2090d19

    126. Hms2095d12

    127. Hms2234f11

    128. Hms3262j11

    129. Hms3374h01

    130. Hms3402f15

    131. Hms3649a08

    132. Hms3656p14

    133. Hms3712d12

    134. Hms3885i03

    135. Nicotinic Acid, 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-

    136. Pharmakon1600-01502015

    137. Zinc125031

    138. Hy-b0493

    139. Niflumic Acid [ep Impurity]

    140. Nsc_4488

    141. Tox21_110206

    142. Tox21_500845

    143. Bbl003619

    144. Ccg-40157

    145. Dl-457

    146. Nicotinic Acid, 2-(.alpha.,.alpha.,.alpha.-trifluoro-m-toluidino)-

    147. Niflumic Acid [ep Monograph]

    148. Nsc758196

    149. S3018

    150. Stk803109

    151. Akos000519590

    152. Tox21_110206_1

    153. Ac-2652

    154. Db04552

    155. Gs-3202

    156. Lp00845

    157. Nsc 758196

    158. Sdccgsbi-0050821.p004

    159. Idi1_000277

    160. Idi1_033863

    161. Ncgc00015724-01

    162. Ncgc00015724-02

    163. Ncgc00015724-03

    164. Ncgc00015724-04

    165. Ncgc00015724-05

    166. Ncgc00015724-06

    167. Ncgc00015724-07

    168. Ncgc00015724-08

    169. Ncgc00015724-09

    170. Ncgc00015724-11

    171. Ncgc00015724-12

    172. Ncgc00015724-13

    173. Ncgc00015724-14

    174. Ncgc00015724-17

    175. Ncgc00015724-29

    176. Ncgc00023636-03

    177. Ncgc00023636-04

    178. Ncgc00023636-05

    179. Ncgc00023636-06

    180. Ncgc00023636-07

    181. Ncgc00023636-08

    182. Ncgc00023636-09

    183. Ncgc00261530-01

    184. Cas_4394-00-7

    185. Sbi-0050821.p003

    186. 2(3'-trifluormethylanilino)-nicotinic Acid

    187. Ab00052255

    188. Am20070143

    189. Eu-0100845

    190. Ft-0603659

    191. Niflumic Acid 100 Microg/ml In Acetonitrile

    192. Sw197011-3

    193. T2353

    194. A23222

    195. D08275

    196. H10042

    197. S00109

    198. Ab00052255-17

    199. Ab00052255_18

    200. Ab00052255_19

    201. 2-((3-(trifluoromethyl)phenyl)amino)nicotinicacid

    202. 394n007

    203. Q304285

    204. Sr-01000000231-2

    205. Sr-01000000231-5

    206. Sr-01000000231-6

    207. W-106215

    208. Brd-k98763141-001-04-3

    209. Brd-k98763141-001-06-8

    210. Brd-k98763141-001-17-5

    211. Sr-01000000231-11

    212. 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic Acid

    213. Niflumic Acid, European Pharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 282.22 g/mol
    Molecular Formula C13H9F3N2O2
    XLogP33.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count3
    Exact Mass282.06161202 g/mol
    Monoisotopic Mass282.06161202 g/mol
    Topological Polar Surface Area62.2 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity349
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Used in the treatment of rheumatoid arthritis.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Niflumic acid, a nonsteroidal anti-inflammatory fenamate, is a Ca2+-activated Cl- channel blocker.

    5.2 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    Cyclooxygenase Inhibitors

    Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

    5.3 ATC Code

    M02AA17

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    M - Musculo-skeletal system

    M01 - Antiinflammatory and antirheumatic products

    M01A - Antiinflammatory and antirheumatic products, non-steroids

    M01AX - Other antiinflammatory and antirheumatic agents, non-steroids

    M01AX02 - Niflumic acid

    M - Musculo-skeletal system

    M02 - Topical products for joint and muscular pain

    M02A - Topical products for joint and muscular pain

    M02AA - Antiinflammatory preparations, non-steroids for topical use

    M02AA17 - Niflumic acid

    5.4 Absorption, Distribution and Excretion

    Absorption

    Well absorbed following oral administration.

    5.5 Metabolism/Metabolites

    Hepatic.

    5.6 Biological Half-Life

    2.5 hours

    5.7 Mechanism of Action

    Niflumic acid is able to inhibit both phospholipase A2 as well as COX-2, thereby acting as an antiinflamatory and pain reduction agent.

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