Acfol (Spain)

ACCESS ALL DATA, CHEMISTRY

ACTIVE PHARMA INGREDIENTS

47 API Suppliers, 8 USDMF, 5 CEP/COS, 1 JDMF, 1 EU WC, 9 NDC API, 33 Listed Suppliers, $ API Reference Price

DEVELOPMENTS

16 Drugs in Development

16 Drugs in Development

INTERMEDIATES

2 Intermediate Suppliers

2 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

365 FDF Dossiers, 57 FDA Orange Book, 98 Europe, 16 Canada, 6 Australia, 33 South Africa, 155 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL, SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML, SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML, INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL, INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

RELATED EXCIPIENT COMPANIES

2 EUROAPI, 10 Evonik, 10 Rochem International Inc, 23 SPI Pharma, 28 DKSH, 1 Pharm-RX Chemical, 8 Boai NKY Pharmaceuticals Ltd, 8 Gangwal Healthcare, 2 Kewpie Corporation, 15 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 18 Kirsch Pharma, 4 ACG Worldwide, 14 Actylis, 3 Aeon Procare, 2 Alcedo Pharmachem, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 4 Ashland, 1 Avesta Pharma, 39 BASF, 1 Bioplus Life Sciences, 4 CD Formulation, 2 Clariant, 16 Corel Pharma Chem, 7 DFE Pharma, 3 Doshion Polyscience, 1 Esteem Industries, 3 Finar, 14 Gangwal Chemicals, 9 Ideal Cures, 5 Ingredion Pharma Solutions, 26 Kerry, 4 Keval Exports, 5 Kima Chemical, 6 Lonza Capsugel, 23 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nitika Pharmaceutical Specialities, 2 Nomisma Healthcare, 4 Novo Excipients, 4 Pharmatrans-Sanaq, 12 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 41 Roquette, 16 Seppic, 8 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 3 Shijiazhuang Huaxu Pharmaceutical, 11 Sigachi Industries, 5 Silverline Chemicals, 4 The Dow Chemical Company, 2 Ulanqab Kema New Material, 3 Valens Pharmachem, 5 Vasa Pharmachem, 2 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

106 Fillers, Diluents & Binders, 76 Coating Systems & Additives, 59 Thickeners and Stabilizers, 53 Parenteral, 51 Solubilizers, 49 Taste Masking, 49 Direct Compression, 46 Disintegrants & Superdisintegrants, 42 Controlled & Modified Release, 39 Granulation, 38 Topical, 33 Film Formers & Plasticizers, 25 Lubricants & Glidants, 25 Chewable & Orodispersible Aids, 18 Emulsifying Agents, 16 Rheology Modifiers, 15 Co-Processed Excipients, 9 Empty Capsules, 9 Surfactant & Foaming Agents, 9 API Stability Enhancers, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

1 Data Compilation #PharmaFlow, 17 News #PharmaBuzz

GLOBAL SALES INFORMATION

56 US Medicaid Prescriptions, 54 Regulatory FDF Prices

MARKET PLACE

67 APIs, 8 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM, 4 JP, 16 Others

ANALYTICAL

1 Analytical Methods

1 Analytical Methods

$ Xls

Filters

Also known as:

Molecular Formula

C₁₉H₁₉N₇O₆

Molecular Weight

441.4 g/mol

InChI Key

OVBPIULPVIDEAO-LBPRGKRZSA-N

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

2.1.2 InChI

InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

2.1.3 InChI Key

OVBPIULPVIDEAO-LBPRGKRZSA-N

2.1.4 Canonical SMILES

C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N

2.1.5 Isomeric SMILES

C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N

2.2 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₉N₇O₆
Molecular Weight	441.4 g/mol
XLogP3	-1.1
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	9
Exact Mass	441.13968135 g/mol
Monoisotopic Mass	441.13968135 g/mol
Topological Polar Surface Area	209 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	767
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Folic acid
PubMed Health	Folic Acid
Drug Classes	Nutriceutical, Nutritive Agent
Drug Label	Folic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
Active Ingredient	Folic acid
Dosage Form	Tablet; Injectable
Route	Injection; Oral
Strength	1 mg; 1mg; 5mg/ml
Market Status	Prescription
Company	Bicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

2 of 2
Drug Name	Folic acid
PubMed Health	Folic Acid
Drug Classes	Nutriceutical, Nutritive Agent
Drug Label	Folic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
Active Ingredient	Folic acid
Dosage Form	Tablet; Injectable
Route	Injection; Oral
Strength	1 mg; 1mg; 5mg/ml
Market Status	Prescription
Company	Bicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

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Acfol (Spain)

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

47 API Suppliers

8 USDMF

5 CEP/COS

1 JDMF

1 EU WC

9 NDC API

33 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

16 Drugs in Development

INTERMEDIATES

2 Intermediate Suppliers

FINISHED DOSAGE FORMULATIONS

365 FDF Dossiers

57 FDA Orange Book

98 Europe

16 Canada

6 Australia

33 South Africa

155 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL

SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL

INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

RELATED EXCIPIENT COMPANIES

2 EUROAPI

10 Evonik

10 Rochem International Inc

23 SPI Pharma

28 DKSH

1 Pharm-RX Chemical

8 Boai NKY Pharmaceuticals Ltd

8 Gangwal Healthcare

2 Kewpie Corporation

15 Nanjing Well Pharmaceutical

2 Pfanstiehl

18 Kirsch Pharma

4 ACG Worldwide

14 Actylis

3 Aeon Procare

2 Alcedo Pharmachem

9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

4 Ashland

1 Avesta Pharma

39 BASF

1 Bioplus Life Sciences

4 CD Formulation

2 Clariant

16 Corel Pharma Chem

7 DFE Pharma

3 Doshion Polyscience

1 Esteem Industries

3 Finar

14 Gangwal Chemicals

9 Ideal Cures

5 Ingredion Pharma Solutions

26 Kerry

4 Keval Exports

5 Kima Chemical

6 Lonza Capsugel

23 Microlex e.U

1 Nanjing Bold Chemical

2 Nitika Pharmaceutical Specialities

2 Nomisma Healthcare

4 Novo Excipients

4 Pharmatrans-Sanaq

12 Pluviaendo

4 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

2 Qualicaps

41 Roquette