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    Technical details about 1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane sulfate, learn more about the structure, uses, toxicity, action, side effects and more

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    1-(3,5-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane sulfate

    APIs // Active Pharmaceutical Ingredients

    DOSSIERs // Finished Dosage Forms

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    2D Structure
    1. Also known as: Prometa, Orciprenaline sulphate, Th-152, Novasmasol, Metaprel, Alotec
    Molecular Formula
    C22H36N2O10S
    Molecular Weight
    520.6  g/mol
    InChI Key
    MKFFGUZYVNDHIH-UHFFFAOYSA-N
    A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]-propan-2-ylazanium;sulfate
    2.1.2 InChI
    InChI=1S/2C11H17NO3.H2O4S/c2*1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8;1-5(2,3)4/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4)
    2.1.3 InChI Key
    MKFFGUZYVNDHIH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.CC(C)[NH2+]CC(C1=CC(=CC(=C1)O)O)O.[O-]S(=O)(=O)[O-]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Alotec

    2. Astmopent

    3. Metaprel

    4. Metaproterenol

    5. Metaproterenol Polistirex

    6. Metaproterenol Sulfate

    7. Orciprenaline

    8. Orciprenaline Sulfate

    9. Polistirex, Metaproterenol

    2.2.2 Depositor-Supplied Synonyms

    1. Prometa

    2. Orciprenaline Sulphate

    3. Th-152

    4. Novasmasol

    5. Metaprel

    6. Alotec

    7. [2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]-propan-2-ylazanium;sulfate

    8. Gj20h50yf0

    9. Einecs 227-539-6

    10. Unii-gj20h50yf0

    11. 1-(3,5-dihydroxyphenyl)-2-(isopropylamino)ethanol Sulfate

    12. 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane Sulfate

    13. Metaproterenol Sulfate [usan:usp]

    14. 3,5-dihydroxy-alpha-((isopropylamino)methyl)benzyl Alcohol Sulfate

    15. 3,5-dihydroxy-alpha-((isopropylamino)methyl)benzyl Alcohol Sulfate (2:1)

    16. (+-)-3,5-dihydroxy-alpha-((isopropylamino)methyl)benzyl Alcohol Sulfate (2:1)

    17. 1,3-benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, Sulfate (2:1) (salt)

    18. 1,3-benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, Sulfate (2:1) Salt

    19. 1,3-benzenediol, 5-(1-hydroxy-2-(1-methylethyl)amino)ethyl-, (+-)-, Sulfate (2:1) (salt)

    20. Benzyl Alcohol, 3,5-dihydroxy-alpha-((isopropylamino)methyl)-, Sulfate (2:1) (salt)

    2.3 Create Date
    2008-07-09
    3 Chemical and Physical Properties
    Molecular Weight 520.6 g/mol
    Molecular Formula C22H36N2O10S
    Hydrogen Bond Donor Count8
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count8
    Exact Mass520.20906652 g/mol
    Monoisotopic Mass520.20906652 g/mol
    Topological Polar Surface Area243 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity239
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameMetaproterenol sulfate
    Drug LabelMetaproterenol sulfate syrup is an oral bronchodilator. Each teaspoonful (5 mL), for oral administration, contains metaproterenol sulfate 10 mg. In addition, each teaspoonful (5 mL) contains the following inactive ingredients:citric acid, edetate dis...
    Active IngredientMetaproterenol sulfate
    Dosage FormTablet; Syrup; Solution
    RouteOral; Inhalation
    Strength10mg/5ml; 0.4%; 0.6%; 10mg; 20mg
    Market StatusPrescription
    CompanyWockhardt; Silarx; Mylan Speclt; Par Pharm

    2 of 2  
    Drug NameMetaproterenol sulfate
    Drug LabelMetaproterenol sulfate syrup is an oral bronchodilator. Each teaspoonful (5 mL), for oral administration, contains metaproterenol sulfate 10 mg. In addition, each teaspoonful (5 mL) contains the following inactive ingredients:citric acid, edetate dis...
    Active IngredientMetaproterenol sulfate
    Dosage FormTablet; Syrup; Solution
    RouteOral; Inhalation
    Strength10mg/5ml; 0.4%; 0.6%; 10mg; 20mg
    Market StatusPrescription
    CompanyWockhardt; Silarx; Mylan Speclt; Par Pharm

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic beta-2 Receptor Agonists

    Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Tocolytic Agents

    Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)

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