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    Technical details about 005SYP50G5, learn more about the structure, uses, toxicity, action, side effects and more

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    005SYP50G5

    APIs // Active Pharmaceutical Ingredients

    PRICE INFORMATION

    ANALYTICAL SOLUTION(s)

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    2D Structure
    1. Also known as: 114-80-7, Eustigmin bromide, Neoserine bromide, Vagostigmin, Kirkstigmine bromide, Syntostigmin bromide
    Molecular Formula
    C12H19BrN2O2
    Molecular Weight
    303.20  g/mol
    InChI Key
    LULNWZDBKTWDGK-UHFFFAOYSA-M
    FDA UNII
    005SYP50G5
    A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide
    2.1.2 InChI
    InChI=1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
    2.1.3 InChI Key
    LULNWZDBKTWDGK-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[Br-]
    2.2 Other Identifiers
    2.2.1 UNII
    005SYP50G5
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bromide, Neostigmine

    2. Methylsulfate, Neostigmine

    3. Neostigmine

    4. Neostigmine Methylsulfate

    5. Polstigmine

    6. Proserine

    7. Prostigmin

    8. Prostigmine

    9. Prozerin

    10. Synstigmin

    11. Syntostigmine

    2.3.2 Depositor-Supplied Synonyms

    1. 114-80-7

    2. Eustigmin Bromide

    3. Neoserine Bromide

    4. Vagostigmin

    5. Kirkstigmine Bromide

    6. Syntostigmin Bromide

    7. Neo-proserin

    8. 3-((dimethylcarbamoyl)oxy)-n,n,n-trimethylbenzenaminium Bromide

    9. Proserine Bromide

    10. Stigmanol Bromide

    11. Synstigmin Bromide

    12. Leostigmine Bromide

    13. Neostigmini Bromidum

    14. Philostigmin Bromide

    15. Prostigmin

    16. Neo Proserine

    17. Neostigmine Methyl Bromide

    18. Bromure De Neostigmine

    19. Bromuro De Neostigmina

    20. Neostigmine (bromide)

    21. Neoproserine

    22. Neostigminebromide

    23. (m-hydroxyphenyl)trimethylammonium Bromide Dimethylcarbamate

    24. 3-[(dimethylcarbamoyl)oxy]-n,n,n-trimethylanilinium Bromide

    25. Nsc-757233

    26. 3-dimethylcarbamoxyphenyl Trimethyl Ammonium Bromide

    27. 114-80-7 (bromide)

    28. Mls000028387

    29. [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide

    30. 3-hydroxyphenyltrimethylammonium Bromide Dimethylcarbamic Ester

    31. Chebi:179557

    32. 005syp50g5

    33. Eustigmin Bromide;neoserine Bromide

    34. Smr000058591

    35. Stigmosan Bromide

    36. Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-, Bromide

    37. Prostigmin Bromide

    38. Dsstox_cid_21075

    39. Dsstox_rid_79621

    40. Prostigmine Bromide

    41. Dsstox_gsid_41075

    42. Synstigmini Bromidum

    43. Vagostigmine Bromide

    44. Syntostigmine Bromide

    45. 3-(dimethylcarbamoyloxy)trimethylanilinium Ion Bromatum

    46. Synthostigmine Bromide

    47. Syntostigmin (tablet)

    48. Synstigminbromid

    49. Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-n,n,n-trimethyl-, Bromide

    50. Neostigmina Bromuro

    51. Neostigmina Bromuro [dcit]

    52. Neostigmini Bromidum [inn-latin]

    53. Sr-01000000073

    54. Ncgc00163240-01

    55. Cas-114-80-7

    56. Einecs 204-054-8

    57. Bromure De Neostigmine [inn-french]

    58. Bromuro De Neostigmina [inn-spanish]

    59. Unii-005syp50g5

    60. Vagostigmin (tn)

    61. Prestwick_352

    62. Mfcd00011795

    63. Neostigmine Bromide [usp:inn:ban:jan]

    64. Opera_id_1504

    65. Carbamic Acid, Dimethyl-, Ester With (m-hydroxyphenyl)trimethylammonium Bromide

    66. Neo Proserine [jan]

    67. Schembl41128

    68. Mls001146913

    69. Chembl54126

    70. Spectrum1500428

    71. Lczc2572

    72. Dtxsid9041075

    73. Neostigmine Bromide (prostigmin)

    74. Neostigmine Bromide [mi]

    75. Hms500i07

    76. Neostigmine Bromide [inn]

    77. Neostigmine Bromide [jan]

    78. Hms1569m18

    79. Hms1920p15

    80. Hms2091h18

    81. Hms2096m18

    82. Hms2235j11

    83. Hms3262d13

    84. Hms3372e02

    85. Hms3713m18

    86. Pharmakon1600-01500428

    87. Neostigmine Bromide [vandf]

    88. 3-(n,n-dimethylcarbamoyloxy)-n,n,n,-trimethylanilinium Bromide

    89. Act05638

    90. Hy-b0423

    91. Neostigmine Bromide [mart.]

    92. Neostigmine Bromide (jan/usp/inn)

    93. Tox21_112037

    94. Tox21_500816

    95. Ccg-39110

    96. Neostigmine Bromide [usp-rs]

    97. Neostigmine Bromide [who-dd]

    98. Neostigmine Bromide [who-ip]

    99. Nsc757233

    100. S2490

    101. Akos015895725

    102. Ammonium, (m-hydroxyphenyl)trimethyl-, Bromide, Dimethylcarbamate

    103. Tox21_112037_1

    104. Lp00816

    105. Nsc 757233

    106. Ncgc00015730-11

    107. Ncgc00094149-01

    108. Ncgc00094149-02

    109. Ncgc00094149-03

    110. Ncgc00094149-04

    111. Ncgc00261501-01

    112. Bs-14646

    113. Neostigmine Bromide [ep Monograph]

    114. Mls-0002855.p042

    115. Neostigmine Bromide [usp Monograph]

    116. Neostigmini Bromidum [who-ip Latin]

    117. Eu-0100816

    118. Ft-0651572

    119. N0358

    120. C08197

    121. C71473

    122. D00995

    123. N 2001

    124. A803245

    125. Sr-01000000073-3

    126. Sr-01000000073-5

    127. Sr-01000000073-7

    128. W-108598

    129. (3-dimethylcarbamoyloxyphenyl)trimethylammonium Bromide

    130. Q27105147

    131. Neostigmine Bromide, >=98% (hplc And Titration), Powder

    132. (3-hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate

    133. [3-[dimethylamino(oxo)methoxy]phenyl]-trimethylammonium Bromide

    134. Neostigmine Bromide, European Pharmacopoeia (ep) Reference Standard

    135. Neostigmine Bromide, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 303.20 g/mol
    Molecular Formula C12H19BrN2O2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass302.06299 g/mol
    Monoisotopic Mass302.06299 g/mol
    Topological Polar Surface Area29.5 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity246
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Cholinesterase Inhibitors

    Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)

    Parasympathomimetics

    Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)

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