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Zylo Therapeutics
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105A Ben Hamby Rd., Greenville, SC 29615
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The agreement aims to create a time-release ketamine implant, SP-26, which blocks the activity of the N-methyl-D-aspartate receptor (NMDAR), to treat fibromyalgia and other chronic pain conditions.


Lead Product(s): Ketamine Hydrochloride

Therapeutic Area: Musculoskeletal Product Name: SP-26

Highest Development Status: PreclinicalProduct Type: Small molecule

Recipient: Silo Pharma

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement June 23, 2023

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The joint venture will initially explore the clinical development of ketamine using ZTI’s Z-pod technology, but also provides for Silo Pharma to obtain an exclusive option for the clinical development of psilocybin using ZTI’s Z-pod technology as well.


Lead Product(s): Ketamine Hydrochloride

Therapeutic Area: Neurology Product Name: Undisclosed

Highest Development Status: UndisclosedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Silo Pharma

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement April 28, 2021

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Results from the study demonstrated that the novel HT-005 loaded Z-pods™ were effective to reduce skin plaques associated with CLE, with statistical significance demonstrated in the overall average skin score as well as individual skin scores on the head and scapula.


Lead Product(s): HT-005 Z-PODS

Therapeutic Area: Immunology Product Name: HT-005

Highest Development Status: PreclinicalProduct Type: Undisclosed

Recipient: Hoth Therapeutics

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 21, 2020

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The animal study supports that HT-005 has the potential to be an effective treatment for cutaneous manifestations of lupus, a significant unmet medical need.


Lead Product(s): HT-005 Z-PODS

Therapeutic Area: Immunology Product Name: HT-005

Highest Development Status: PreclinicalProduct Type: Undisclosed

Recipient: Hoth Therapeutics

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 03, 2020

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