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VS-6766 (avutometinib) is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS pathway inhibition.
Lead Product(s): VS-6766,Defactinib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 05, 2024
Details:
VS-6766 (avutometinib) in combination with Lumakras (sotorasib) is being evaluated in phase 1/2 clinical studies for the treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer (NSCLC).
Lead Product(s): VS-6766,Sotorasib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase I/ Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable January 18, 2024
Details:
Under the collaboration, Verastem selects a potential best-in-class KRAS G12D oral selective small molecule inhibitor, GFH375/VS-7375, as the lead program for its discovery and development for therapeutics targeting KRAS mutations.
Lead Product(s): VS-7375
Therapeutic Area: Oncology Product Name: GFH375
Highest Development Status: PreclinicalProduct Type: Small molecule
Partner/Sponsor/Collaborator: GenFleet Therapeutics
Deal Size: $625.5 million Upfront Cash: Undisclosed
Deal Type: Collaboration December 18, 2023
Details:
VS-6766 (avutometinib) is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS pathway inhibition.
Lead Product(s): VS-6766,Defactinib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase IIIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 13, 2023
Details:
The collaboration is designed to allow Verastem the flexibility of a milestone-based option to license up to three compounds. The licenses would give Verastem development and commercialization rights outside of China while GenFleet would retain rights inside of China.
Lead Product(s): Undisclosed
Therapeutic Area: Oncology Product Name: Undisclosed
Highest Development Status: DiscoveryProduct Type: Small molecule
Partner/Sponsor/Collaborator: GenFleet Therapeutics
Deal Size: $637.0 million Upfront Cash: $11.5 million
Deal Type: Collaboration August 28, 2023
Details:
VS-6766 (avutometinib) is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF potentially creating a more complete and durable anti-tumor response Low-Grade Serous Ovarian Cancer through maximal RAS pathway inhibition.
Lead Product(s): VS-6766,Defactinib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable July 05, 2023
Details:
Verastem Oncology intends to use the net proceeds for potential launch of VS-6766 (avutometinib), a small molecule RAF/MEK clamp, and defactinib in low-grade serous ovarian cancer.
Lead Product(s): VS-6766,Defactinib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: RBC Capital Markets
Deal Size: $85.0 million Upfront Cash: Undisclosed
Deal Type: Public Offering June 16, 2023
Details:
VS-6766 (avutometinib) is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS pathway inhibition.
Lead Product(s): VS-6766,Defactinib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable May 25, 2023
Details:
VS-6766 is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS pathway inhibition.
Lead Product(s): VS-6766,Defactinib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Truist Securities
Deal Size: $60.0 million Upfront Cash: Undisclosed
Deal Type: Private Placement January 24, 2023
Details:
VS-6766 (avutometinib) is a RAF/MEK clamp that induces inactive complexes of MEK with ARAF, BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS pathway inhibition.
Lead Product(s): VS-6766,Defactinib
Therapeutic Area: Oncology Product Name: VS-6766
Highest Development Status: Phase IIProduct Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable January 24, 2023
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