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Tenax Therapeutics
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U.S.A
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ONE Copley Parkway, Suite 490, Morrisville, NC 27560
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(919) 855-2100
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Under the license agreement, Tenax will be developing and commercializing the TNX-103 (levosimendan) for the treatment of pulmonary hypertension with heart failure with preserved ejection fraction.


Lead Product(s): Levosimendan

Therapeutic Area: Cardiology/Vascular Diseases Product Name: TNX-103

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Orion Corporation

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement February 20, 2024

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The company intends to use the net proceeds for the clinical development of TNX-103 (levosimendan) for the treatment of pulmonary hypertension and heart failure with preserved ejection fraction.


Lead Product(s): Levosimendan

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: TNX-103

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Roth Capital Partners

Deal Size: $9.0 million Upfront Cash: Undisclosed

Deal Type: Public Offering February 08, 2024

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Details:

TNX-103 (levosimendan) is a potassium ATP channel activator and calcium sensitizer that affects the heart & vascular system. It is being evaluated in phase 3 trials for the treatment of pulmonary hypertension in heart failure with preserved ejection fraction (PH-HFpEF).


Lead Product(s): Levosimendan

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: TNX-103

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 07, 2024

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TNX-103 (levosimendan), is an oral, small molecule, unique potassium ATP channel activator and calcium sensitizer, being developed for Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction. There are currently no FDA approved treatments for PH-HFpEF.


Lead Product(s): Levosimendan

Therapeutic Area: Cardiology/Vascular Diseases Product Name: TNX-103

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 13, 2023

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Details:

TNX-103 (levosimendan), is an oral, small molecule, unique potassium ATP channel activator and calcium sensitizer, being developed for Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction. There are currently no FDA approved treatments for PH-HFpEF.


Lead Product(s): Levosimendan

Therapeutic Area: Cardiology/Vascular Diseases Product Name: TNX-103

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 31, 2023

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Details:

TNX-101 (levosimendan) is a unique potassium ATP channel activator and calcium sensitizer that affects the heart and vascular system through multiple mechanisms of action.


Lead Product(s): Levosimendan

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: TNX-101

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 22, 2023

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Details:

The Company intends to use the net proceeds to progress the clinical development of TNX-201 (imatinib) for the treatment of PAH and levosimendan for the treatment of PH-HFpEF, toward regulatory approval for the treatment of these and potentially other indications.


Lead Product(s): Imatinib Mesylate

Therapeutic Area: Cardiology/Vascular Diseases Product Name: TNX-201

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Roth Capital Partners

Deal Size: $15.6 million Upfront Cash: Undisclosed

Deal Type: Public Offering February 03, 2023

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Details:

TNX-101 (levosimendan) is a unique potassium ATP channel activator and calcium sensitizer that affects the heart and vascular system through multiple mechanisms of action.


Lead Product(s): Levosimendan

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: TNX-101

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 01, 2023

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Details:

Levosimendan (TNX-102 and TNX-103) is a unique potassium ATP channel activator and calcium sensitizer that affects the heart and vascular system through multiple mechanisms of action.


Lead Product(s): Levosimendan

Therapeutic Area: Cardiology/Vascular Diseases Product Name: TNX-102

Highest Development Status: Phase IIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Orion Corporation

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 10, 2022

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Details:

TNX-201 (imatinib), a novel, oral, modified release formulation, a kinase inhibitor that has received FDA’s orphan designation for the treatment of pulmonary arterial hypertension (PAH).


Lead Product(s): Imatinib Mesylate

Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: TNX-201

Highest Development Status: Phase IIIProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 25, 2022

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